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Original Article

Comparison of Conventional Inflammatory Parameters with Tumor Necrosis Factor- α Levels in Different Stages of Diabetic Retinopathy and Non-Diabetic Controls

Metin Guclu, Berkant Kaderli, Canan Ersoy

   

Abstract
Aim of this study was to identify the risk factors associated with diabetic retinopathy in patients with Type 2 diabetes mellitus(DM), and to compare the levels of erythrocyte sedimentation rate (ESR), high sensitive CRP(hs-CRP) and tumor necrosis factor-α (TNF-α), in patients with every stage of diabetic retinopathy and non-diabetic healthy controls. A total of 79 individuals, 64 diabetic and 25 healthy controls were included in the study. Patients were divided into three groups. Group 1 consisted of those without diabetic retinopathy (DR) (n=26), group 2 with non-proliferative (NPDR) (n=19), and group 3 with proliferative diabetic retinopathy (PDR) (n=19). Even though the similar age distribution, disease duration were different as 6.9 ± 6.5, 10.3 ± 5.4, and 12.7 ± 5.1 years in Group 1, Group 2 and Group 3, respectively (p>0.001). The majority of the patients with PDR were male, had high levels of albuminuria and high percents of receiving insulin treatment (p

Key words: Diabetic retinopathy, inflammation, hs-CRP, TNF-α, postprandial blood glucose

Med-Science. 2015; 4(3): 2364-78

Medicine Science Vol:4 Issue:3 Year:2015 PP:2356-2699
Posted in Vol: 4 Issue: 3 Year: 2015 September pp: 2356-2699

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