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Original Artcile

The effect of licorice drink on cytochrome P3A6 and P-glycoprotein gene transcription in rabbits

Rawia Al-Balawnih, Suheil Zmeili, Yacoub Irshaid, Malek Zihlef

   

Abstract
The effect of licorice drink, a widely used herb in the Middle East, on hepatic and intestinal cytochrome P3A6 (CYP3A6) and P-glycoprotein (P-gp) gene transcription using rabbit as an animal model was assessed. This article reports that licorice treated groups showed a significant induction of hepatic CYP3A6 expression by 17.6-folds, and an inhibition of intestinal CYP3A6 expression by 7.6-folds. Licorice administration did not affect P-gp expression neither in hepatic nor in intestinal tissues. It is concluded that licorice can affect the metabolism of drugs that are CYP3A6 substrates, but it might not affect the transport of drugs dependent on P-gp.

Key words: Licorice, CYP3A4, CYP3A6, P-gp, rifampicin, transcription

Med-Science. 2017; 6(1): 35-40

 
Medicine Science Vol:6 Issue:1 Year:2017 PP:1-181
Posted in Vol: 6 Issue: 1 Year: 2017 March pp: 1–181

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