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Original Artcile

The effects of ankaferd blood stopper on DNA damage and enzymes with paranchymal damaged rabbits

Bayram Metin, Esma Menevse, Abdullah Sivrikaya, Tamer Altinoks, Hilal Arikoglu

   

Abstract
Ankaferd blood stopper (ABS) is a medical product that is used in several injuries, dental operations, prevention of minor or major bleeding after spontaneous or surgerical operations and have anti-microbial, anti-inflamatory, anti-thrombin, anti-platelet, anti-atherosclerotic, anti-oxidants effects. The present study is aimed to evaluate the effects of ABS on 8-hydroxy-2ˈ-deoxyguanosine (8-OHdG), superoxide dismutase (SOD), myeloperoxidase (MPO) levels over pleural adhesions in rabbits with pulmonary parenchymal damage.16 New Zelland species rabbits were divided in two groups such as control (n=7) and study group (n=7). One rabbit in each group died during anesthesia. In both groups, we performed wedge resections in equal size to the left lower lobes of all rabbits. No interventions were made on control group, whereas 5 puff’s (1 cc) ABS was performed to the resection area at study group. Tube thoracostomy that performed both groups were terminated postoperatively at 6th hour after drainage and air leakages follow up. Rabbits were sacrificed with anesthetics at postoperative 8th day. Lung tissues were collected for analyzing of 8-OHdG, SOD, MPO. The 8-OHdG levels were respectively 2.01±0.39 ng/ml in control group and, 0.38±0.12 ng/ml in study. The differences between study and control group were statistically important group (p

Key words: Ankaferd, paranchyme damage, 8-hydroxy-2ˈ-deoxyguanosin, superoxide dismutase, myeloperoxidase

Med-Science. 2017; 6(1): 5-10

 
Medicine Science Vol:6 Issue:1 Year:2017 PP:1-181
Posted in Vol: 6 Issue: 1 Year: 2017 March pp: 1–181

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