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Adverse drug reactions report among hospitalized patients with hypertension in a Nigerian Tertiary Healthcare Centre: a retrospective study

Abiola Muhammad Adeosun, Aduragbenro D.A. Adedapo, Waheed Adeola Adedeji


Adverse drug reactions (ADRs) are serious clinical problem with growing global concern. This study focused on incidence and outcome of ADRs among in-patients with hypertension in Nigeria. This is a descriptive, cross-sectional study on incidence of adverse drug reactions among in-patients with hypertension conducted in the University College Hospital (UCH), Ibadan, Nigeria, within June 2012 to May 2013. Of 196 patients, 105 (53.6%) were male, and 91 (46.4%) were female. Prevalence of ADRs was 53 (27.04%), of these, 28 (52.8%) were male, and 25 (47.2%) were female patients. Adverse drug reaction was cause of admission in 2 (1.02%) patients. Prevalence of ADRs during hospitalized was 51 (26.02%) patients. Patients with adverse drug event spent approximately additional 5 days more in bed compared to those without adverse drug reactions (p = 0.028) . ADRs experienced by the patients were managed by withdrawing the suspected drug(s). ADR recorded among hospitalised patients with hypertension was 27.04%. ADR was cause of admission in 1% of in-patients with hypertension. Patients that experienced ADR spent additional five days in hospital compared to those without adverse drug effect during hospitalization.

Key words: Adverse drug reaction, hospitalized patients, incidence, hypertension, dechallenge

Med-Science. 2017; 6(2): 276-9

Medicine Science Vol:6 Issue:2 Year:2017 PP:182-388
Posted in Vol: 6 Issue: 2 Year: 2017 June pp: 182-388

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