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Original Article

Effects of L-Carnitine and N-Acetylcysteine on nonalcoholic hepatic steatosis in rats

Cemal Nas; Mehmet Tahir Gokdemir; Naime Canoruc; Mehmet Yaldiz

   

Abstract
This study was performed to investigate whether the antioxidants L-carnitine and N-acetylcysteine (NAC) have therapeutic effects on Nonalcoholic hepatic steatosis (NHS) in rats with carbon tetrachloride (CCl4)-induced fatty liver disease. Twenty-four healthy male and female Wistar Albino rats, weighing 220–250 g and obtained from our university health research institute, were used in this study. The animals were divided into four groups of six rats each: Group 1 [Diet + normal saline solution (NSS), control group], Group 2 [Diet + CCl4], Group 3 [Diet + CCl4 + L-carnitine] and Group 4 [Diet + CCl4 + NAC]. For biochemical examinations blood samples were obtained from the right ventricle of the heart and liver samples for histopathological were also obtained. The mean Aspartate aminotransferase (AST) (P = 0.043) and lactate dehydrogenase (LDH) levels (P=0.021) were significantly lower in rats with l-carnitine treatment. The mean ALT level were significantly lower in rats with NAC and (P = 0.014). Microscopic steatosis severity was decreased in the rats with NAC treatment than the controls. However administration of l-carnitine did not sufficiently prevent hepatic steatosis or inflammation. Our study showed that L-carnitine and NAC treatment resulted in significant regression of steatosis in rats with NHS. However, these findings must be confirmed by further studies including larger populations.

Key words: L-Carnitine;N-Acetylcysteine;nonalcoholic hepatic steatosis;rats

Med-Science. 2019; 8(2): 401-6

 

Medicine Science Vol:8 Issue:2 Year:2019 PP:260-488
Posted in Vol: 8 Issue: 2 Year: 2019 June pp: 260-488

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