Olanzapine is a second generation antipsychotic which has antagonistic action on serotonergic, histaminergic, dopaminergic, and muscarinic receptors. The most common seen side effects of olanzapine are weight gain, dry mouth, dizziness, and constipation. There are case reports with olanzapine especially as peripheral edema. Herein, we present a female patient who developed bilateral pedal and pretibial edema after treatment with olanzapine added to sertraline. In this case, the systemic causes of edema were ruled out. The edema resolved completely one week after cessation of the treatment. The patient was managed by aripiprazole and sertraline and the same side effect was not seen with this medication.