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Original Article

Prevalence of hypouricemia, possible causes and clinical outcome

Can Huzmeli


Hypouricemia is usually defined as serum uric acid level <2,0 mg/dL. Hypouricemia has no symptoms and usually does not require treatment. But it can lead to nephrolithiasis clinically and acute kidney damage after exercise. There are many possible causes of hypouricemia, such as malignancy and diabetes mellitus. In this study, we aimed to investigate the prevalence and possible causes of hypouricemia and clinical outcomes. Patients who applied to the Kahramanmaras Necip Fazıl City Hospital between January 2016 and December 2017 and patients with serum uric acid levels were included in the study. Individuals with serum uric acid levels <2 mg/dl were screened and their diagnoses and treatments were noted. Renal ultrasonography was also evaluated for nephrolithiasis in patients with hypouricemia. A total of 59755 patients were included in the study. The prevalence of hypouricemia was determined as 0.88% (531/59755). The prevalence of hypouricemia was determined as 0.74% (365/49286) in the outpatient and 1.58% (166/10469) in the hospitalized patients. Of the patients diagnosed with hypouricemia, 77.9% were female and 22.0% were male. The prevalence of hypouricemia among female patients was found to be 1.06% (414/38701) and 0.55% (117/21054) among male patients. Possible causes include malignancy, diabetes mellitus, hypertension, pregnancy, intracranial pathology, burns and drugs. Clinically, acute renal failure, hyponatremia, chronic kidney disease and nephrolithiasis were detected. There were no illnesses or drug use stories in 114 cases. As a result, the prevalence of hypouricemia was found to be 0.88%. It was found higher in hospitalized patients and women.

Key words: Hypouricemia, malignancy, nephrolithiasis

Med-Science. 2019; 8(3): 500-2

Medicine Science Vol:8 Issue:3 Year:2019 PP:489-773
Posted in Vol: 8 Issue: 3 Year: 2019 September pp: 489-773

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