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Original Article

Safety of midazolam-propofol combination for sedation in pediatric patients undergoing gastrointestinal endoscopy

Sami Eksert, Necati Balamtekin, Mustafa Gulgun, Mehmet Emin Ince


In recent years, the number of pediatric gastrointestinal procedures with anesthesia has increased. Purpose of this study is to evaluate the safety and efficacy of midazolam and propofol combination used in pediatric patients by anesthesiologists for upper and lower gastrointestinal system endoscopy and determine whether there is any difference in the sedation complications and recovery of anesthesia between age groups. The records of 273 patients aged between 3 and 17 who underwent upper and/or lower gastrointestinal system endoscopies were analyzed retrospectively. Complications, vital signs and modified Aldrete recovery scores were recorded. The patients were grouped as those under and over 5 years of age for comparison. There was no significant difference in the rate of complications between age groups (p =0.42, p=0.72). The rate of attained recovery for patients under 5 years of age and over 5 years of age were statistically significant at the 5th (p=0.014). The present study demonstrates that deep sedation with propofol and midazolam combination for pediatric elective esophagogastroduodenoscopies are provided safely by anesthesiologist with close monitoring. Patients under 5 years of age tend to recover more slowly from the drug effects. Thus, we recommend closer follow-up for children under 5 years of age in post-procedure period.

Key words: Propofol, midazolam, pediatrics, endoscopy

Med-Science. 2019; 8(3): 716-9

Medicine Science Vol:8 Issue:3 Year:2019 PP:489-773
Posted in Vol: 8 Issue: 3 Year: 2019 September pp: 489-773

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