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Original Article

Kinetic evaluation of L-Dopa loaded WGA-grafted nanoparticles

Sema Arisoy, Tansel Comoglu


Drug release is a critical parameter in the discipline of drug delivery for years. The determination of in vitro release kinetics of active substances from drug systems plays a critical role in predicting and managing of both efficacy and safety. Kinetics is more than a scientific goal; it is a fundamental quality parameter of all type of drugs. Kinetic models are developed to determine drug release from delivery systems which the released drug amount (Q) is plotted versus time; t or as a function of time Q=f (t). Kinetic models facilitate the understanding of release pattern in enabling to design an effective formulation. In this study wheat germ agglutinin (WGA) conjugated, L-Dopa loaded, poly lactic-co-glycolic acid (PLGA) nanoparticles were analyzed for determining the release pattern of L-Dopa. Higuchi, zero order, first order, Hixon Crowell and Korsmeyer-Peppas models were investigated. Hixson Crowell model was found to be the best fitted kinetic model in L-Dopa loaded nanoparticles (r2 =0.9828).

Key words: Kinetic evaluation, first order, zero order, hixon-crowell, korsmeyer-pepas, higuchi

Med-Science. 2020; 9(2): 385-8

Medicine Science Vol:9 Issue:2 Year:2020 PP:289–525
Posted in Vol: 9 Issue: 2 Year: 2020 June pp: 289–525

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