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Original Article

The effect of lactate/albumin ratio on mortality in patients with sepsis

Kamile Yucel, Ali Fuat Gurbuz

   

Abstract
The aim of study was to evaluate the lactate/ albumin ratio, procalcitonin (ProCT) and C reactive protein (CRP) levels in patients with sepsis. For the study, 207 patients with sepsis who were treated in intensive care between January 1st, 2016 and January 1st, 2021 were analyzed retrospectively. The patients’ age, sex, diagnosis for hospitalization, lactate levels during the admission (lactate 1) and discharge (lactate 2), CRP, ProCT and albumin, levels registered in patients’ files were recorded from the hospital automation system and their effect on the mortality was statistically analyzed. The patients were grouped as those aged older than 65 and younger than 65, and those with and without mortality. The study included 207 patients diagnosed with sepsis (96 female, 111 male). ProCT levels were found significantly higher in the group older than 65 in the present study. In this study, according to the data obtained, there was no difference in lactate1/albumin and lactate2/albumin ratio in terms of age groups and sex. However, lactate1/albumin and lactate2/ albumin ratio were significantly higher in the group with mortality than the group without mortality. According to our ROC analysis results; The AUC for lactate1, lactate2, lactate1/albumin and lactate2/albumin ratio was 0.649, 0.680, 0.690, 0.771, respectively. The lactate/albumin ratio is a readily available parameter with consistently better prognostic performance than initial serum lactate for in-hospital mortality in adult patients with sepsis. Raised lactate/albumin ratio showed significant association with increased mortality in patients with sepsis.

Key words: C-Reactive Protein, lactate/ albumin ratio, mortality, procalcitonin, sepsis

Med-Science. 2021; 10(3): 939-45

 

 
Medicine Science Vol:10 Issue:3 Year:2021 PP:670–1086
Posted in Vol: 10 Issue: 3 Year: 2021 September pp: 670–1086

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