The association between visceral adiposity index levels and the change of the glomerular filtration rate in patients with chronic kidney disease
Obesity is an expanding health challenge due to its increasing prevalence across the world. Obesity is associated with chronic kidney disease (CKD) with the advancement of diabetes mellitus (DM) and hypertension (HT), causing CKD by affecting the kidneys directly. The visceral adiposity index (VAI) has recently been developed to assess the metabolic function of visceral adipose tissue (VAT). Previous studies demonstrated that the prevalence of VAI was associated with CKD. The present study aimed to investigate the association between the decline of estimated glomerular filtration rate (eGFR) and VAT. Followed in the Nephrology Department of Research and Training Hospital for one year, 129 patients aged between 18-80 years with stages 2-5 CKD and not on dialysis were enrolled into the study. Sixty-three (40.6%) patients were females, and the mean age was 66.8 years. The averages of decreased eGFR and VAI values were also found as 12.8±19.0 mL/min/1.73 m2 and 2.86±1.63, respectively. The values of VAI were not correlated with the decrease in eGFR. The VAI values (p=0.03) and eGFR decrease (p=0.04) were higher in those with DM. Developed to indicate the metabolic effect of VAT, VAI has shown no association with the one-year decrease of eGFR in those with CKD.
Key words: Chronic kidney disease, diabetes mellitus, obesity, visceral adiposity