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Effects of Maximal Anaerobic Exercise on Neutrophil Oxidants/Antioxidants in among the Sportsmen Trained at Various Levels

Original Article

Effects of Maximal Anaerobic Exercise on Neutrophil Oxidants/Antioxidants in among the Sportsmen Trained at Various Levels

Duzova H, Erdogan H, Fadillioglu E, Emre MH

   

Abstract
The influence of very high intensity exercise on antioxidant capacity and oxidative burst activity of neutrophils in sportsmen with various levels of training status were examined. Blood samples from sportsmen with high (n=12, 5 hours training program for a week), moderate (n=9, 2-5 hours training program for a week), and low physical activity (n=11, less than 2 hours training program for a week) were collected to determine superoxide anion production, superoxide dismutase, catalase and glutathione peroxidase activity and TBARS in neutrophils before and after an “anaerobic loading coordination test”. The pre-exercise values of SOD activity were significantly higher in high and moderate physical activity groups in comparison with the low physical activity group (p

Key words: Superoxide anion, TBARS, neutrophils, maximal aerobic exercise

Med-Science. 2012; 1(2): 77-89

 
Medicine Science Vol:1 Issue:2 Year:2012 PP:77-160

Investigation of Antithrombotic Drug Effects on Preventing Thrombosis Emerging in Gluteus Maximus Flaps before Anastomosis

Original Article

Investigation of Antithrombotic Drug Effects on Preventing Thrombosis Emerging in Gluteus Maximus Flaps before Anastomosis

Ertem K, Guner E, Kirimlioglu H, Karakoç Y

   

Abstract
Aim of this study was to investigate the effects of thromboprophylactic agents at pre-anastomotic period of thrombosis in gluteus maximus muscle flaps. Forty five male Sprague-Dawley rats that have 289 g average weight were randomly diveded into 9 experiment groups and, each group was consisted of five rats. The first group was a control (sham) and not treated with antithrombotic agents. The other groups were consisted of rats treated with SC heparin, SC LMWH, oral aspirin and the combinations of these groups with IV heparin, and only treated with IV heparin and flaps of these groups were washed with % 10 heparin solution. For the ninth group, we didn’t give any thromboprophylactic agents but washed flaps with % 10 heparin solution. The presence of fibrinogen, vWf and the thrombomoduline were investigated in the flap tissues. A diffuse thrombosis was evaluated in the sham group. There was found the lowest thrombosis findings in SC heparin group. A mild to moderate degree of thrombosis was seen in the SC LMWH, oral aspirin or IV heparin injected group. In this animal model, preoperative SC heparin treatment has significant thrombroprophylactic effect when used alone but not in combination.

Key words: flaps, thrombosis, antithrombotic drugs

Med-Science. 2012; 1(2): 90-102

 

The Effect of Breathing and Posture Exercise on the Clinical, Functional Status and Disease Related Quality of Life in Patients with Ankylosing Spondylitis

Original Article

The Effect of Breathing and Posture Exercise on the Clinical, Functional Status and Disease Related Quality of Life in Patients with Ankylosing Spondylitis

Özbaş Günay M, Bal S, Bayram KB, Harman E, Dalgıç EE, Koçyiğit H, Gürgan A

   

Abstract
Objectives: The aim of this study was to investigate the effects of breathing and posture exercises on pain, functional status as well as respiratory function and health related quality of life in patients with Ankylosing Spondylitis (AS).
Materials and Methods: Forty patients with AS were included in the study. Pain levels were recorded by Visual Analog Scale (VAS). Disease activity levels were determined by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), functional status was determined by Bath Ankylosing Spondylitis Functional Index (BASFI) and spinal measurements were determined by the Bath Ankylosing Spondylitis Metrology Index (BASMI) criteria. Ankylosing Spondylitis Quality of Life (ASQol) was used as the disease-related quality of life scale. Pulmonary functions were tested with the Zan spirometry device. The first group was given a home exercise program including breathing and posture exercises and the second group was given a program with only posture exercises. However, the control group was not given a home exercise program. Patients in all groups were evaluated again after three months.
Results: The VAS, BASDAI, BASFI, BASMI, chest expansion, pulmonary function test results and ASQol values showed a significant improvement in the group with breathing and posture exercises. There was no significant change in the control group. Chest expansion, forced vital capacity (FVC), forced expiratory volume in the first second (FEV1)/FVC ratio in the first group had improved more significantly than group 2 and the control group. Also, BASFI, BASMI, BASDAI, ASQol, VAS scores in group 1 had improved more significantly when compared to group 2 and the control group.
Conclusion: Breathing exercises show a positive effect on the pain level, clinical status and respiratory function and provides improved functional status and quality of life in patients with AS.

Key words: Ankylosing Spondylitis, Exercise, Respiratory Function

Med-Science. 2012; 1(2): 103-117

 

A Study of Feto-Maternal Outcome in Patients with Prelabour Rupture of Membranes at Term (>37 Weeks)

Other

A Study of Feto-Maternal Outcome in Patients with Prelabour Rupture of Membranes at Term (>37 Weeks)

Vaishnav J, Vaishnav G

   

Abstract
To determine the fetomaternal out come in patients with premature rupture of membrane after 37 completed weeks, but before onset of labour. Prospective case control study of 66 patients. Incidence of PROM was 8.09 % during study period, 1.79 % applicable for study. No correlation found between PROM and delivery interval and mode of delivery. No correlation between mode of delivery and gravida status and labour induced with Misoprostol or not. 54.5 % (36) induced with Misoprostol 25µg and more, 7 (10.61%) developed minor side effects, like nausea in 6 (9.09%) patients and vomiting and fever (100.2ºF), 5(7.58%) patient. No significant difference in mode of delivery in cases and control. Mean PROM-delivery interval 11.67 hrs in induced versus 8.05 hrs in spontaneous group. Hospital stay in cases was 6.87 days, is higher in study group compare to controls, mostly due to antibiotics given to baby, so mother was kept ward. Neonatal CRP is significantly higher around 30.30 % & almost all required antibiotics. 20 babies had CRP and 2 had raised total count in case group. Only 1 baby in the case with MBA, kept in NICU for observation for one day. These are not comparable due to small sample size in the study.

Key words: PROM, Fetomaternal outcome, induction of labour

Med-Science. 2012; 1(2): 118-124

 

Abnormal 99mTc-MDP uptake in radiation nephritis: A Case Report

Case Report

Abnormal 99mTc-MDP uptake in radiation nephritis: A Case Report

Kekilli E, Batı F, Köksal İ, Köroğlu R, Aluçlu MA, Subaşı V

   

Abstract
The radiation nephritis is a long-term degenerative injury involving nephron and mesangium after radiation exposure. 51 year-old male patient who underwent gastric surgery due to adenocarcinoma 18 months ago and had postoperative chemo-radiotherapy using FUFA Mayo Clinic regimen after surgical resection of gastric cancer. After one year from end of the radiation therapy, bone scan showed markedly increased 99mTc-MDP uptake in the upper pole of the left kidney.

Key words: radiation nephritis, bone, scintigraphy

Med-Science. 2012; 1(2): 125-130

 

Case Report: Intraarticular osteoid osteoma of the hip; a challenging diagnosis

Case Report

Case Report: Intraarticular osteoid osteoma of the hip; a challenging diagnosis

Demiralp B, Yildiz C, Keskinbora M, Kose O, Basbozkurt M

   

Abstract
Osteoid osteoma (OO) is a relatively common benign skeletal neoplasm of unknown etiology that is composed of osteoid and woven bone. Although, the clinical, radiological and scintigraphic features of OO have been well described, these features may be misleading or altered in the cases of intra-articular involvement. The acetabulum is a relatively uncommon location for OO with a few number of cases reported up to date. We reported a case of a 28-year-old man with intra-articular OO of the hip, located beneath the acetebular rim. Computed tomography, magnetic resonance imaging and bone scans were all nonspecific and confusing. We could show the nidus with the help of PET/CT. The final diagnosis and surgical excision can be made 6 months after the first on set of complaints. Intraarticular OO can mimic lots of pathologic entities related to the affected joint, and presents a diagnostic challenge and cause a delay in the diagnosis. The delays in the diagnosis and treatment can be avoided with a high index of suspicion. Furthermore, PET/CT is a useful imaging modality to demonstrate the tumor especially in the intraarticular location even in the absence of a characteristic nidus. Treatment should be individualized according to the surgeon’s preference and the characteristics of the case.

Key words: Osteoid osteoma, hip, acetabulum, positron emition tomography (PET/CT)

Med-Science. 2012; 1(2): 131-140

 

HDL-C as a new therapeutic target in the treatment of dyslipidemia

Review Article

HDL-C as a new therapeutic target in the treatment of dyslipidemia

Sahin I

   

Abstract
Clinical and epidemiological studies have suggested that low plasma levels of high-density lipoproteins cholesterol (HDL-C) are independently associated with an increased risk of cardio-vascular diseases (CVD). Accumulated data from epidemiologic, animal models and clinical studies support the view that raising HDL may be an effective new target to decrease cardio-vascular risks. New insights in the understanding of the physiology, mechanisms and pathways by which HDL may reduce atherosclerosis allow new promising agents for increasing plasma HDL-C. In this regards, apo-AI analogs, acute HDL-C infusions therapies and new cholesteryl ester transfer protein CETP inhibitors have opened new expectations in the treatment of CVD.

Key words: HDL, cardiovascular risks, treatment

Med-Science. 2012; 1(2): 141-149

 

Management of Pediatric Severe Head Trauma

Review Article

Management of Pediatric Severe Head Trauma

Onal C

   

Abstract
The management of a child with severe traumatic brain injury requires multidisciplinary approach. Maintanence of a secure airway, stabilization of breathing and circulation are essential. After the emergent interventions, the management should be focused on optimizing the brain perfusion, establishing the metabolic balance, and prevention of cerebral edema. Besides the neurological state, laboratory information and radiological findings should closely be followed-up. Unfortunately, literature data focusing on pediatric severe traumatic brain injury is stil limited.

Key words: brain, child, head, injury, trauma

Med-Science. 2012; 1(2): 150-160