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The efficacy of oral versus parentral vitamin D in treatment of nutritional rickets

Original Article

The efficacy of oral versus parentral vitamin D in treatment of nutritional rickets

Hoda M. Rabea, Mohamed E.A. Abdelrahim, Mohamed H. Meabed

   

Abstract
Rickets is the most common form of metabolic bone disease in children. Vitamin D deficiency rickets is clearly a problem in breast-fed infants who do not receive enough vitamin D or adequate sunshine exposure.
The study was carried out on 30 patients who had clinical evidence of rickets. Patients were divided into three equal groups. Group A received 600,000U IM once; group B received 20,000U IM three times a week for two weeks and group C received 2000U/day orally for a month. The aim of this study was to compare the effect of different doses of ergocalciferol on serum calcium, phosphorous and alkaline phosphatase.
Results show that the serum alkaline phosphatase concentration significantly decreased more in the group B compared to group A and group B (p=0.013 and p=0.001, respectively).
Patients who received the intramuscular dose responded promptly, whereas infants who received the oral dosages had less response.

Key words: 1,25-dihydroxyvitamin D; 25-hydroxyvitamin D; rickets ; vitamin D; vitamin D-dependent rickets

Med-Science. 2012; 1(4): 244-53

 
Medicine Science Vol:1 Issue:4 Year:2012 PP:244-362

The Effect of Selective Endothelin Receptor a Antagonism by Bq-123 on Myocardial Ischemia-Reperfusion Induced Apoptotic Cell Death

Original Article

The Effect of Selective Endothelin Receptor a Antagonism by Bq-123 on Myocardial Ischemia-Reperfusion Induced Apoptotic Cell Death

Mehmet Cengiz Colak, Hakan Parlakpinar, Necip Ermis, Alaadin Polat, Cemil Colak, Bulent Mizrak, Ramazan Ozdemir, Ahmet Acet

   

Abstract
The objective of the present study was to investigate the possible impact of specific endothelin-A (ETA) receptor blockage by BQ-123 on myocardial ischemia-reperfusion (MI/R) induced apoptosis in rats. To produce MI/R, a branch of the descending left coronary artery was occluded for 30 min followed by 2 h reperfusion. Thirty-two rats were randomly assigned to four groups equally: (1) sham-operated group, (2) MI/R group, (3) MI/R+BQ-123-treated group, and (4) MI/R+ET-1+BQ-123-treated group. TUNEL staining, caspase-3 and caspase-9 activities were determined immunohistologically. MI/R group revealed extensive TUNEL positive cardiomyocytes especially in the free wall of the left ventricule, interventicular septum, and apex zone. Intensity of TUNEL-positive cardiomyocytes reduced as a result of BQ-123 treatment compared to the sham group in the same sections. Result of the caspase activity was found to correlate with TUNEL evaluation. BQ-123 administrations to MI/R group with or without ET-1 caused significant decrease both in lipid peroxidation and nitric oxide (NO) generation. Also, BQ-123 leads to augmentation of superoxide dismutase, catalase and glutathione contents. We propose that selective ETA antagonism by BQ-123 has a worthwhile effect on apoptotic cell death following MI/R, and that scavenging of free radicals by selective ETA antagonist is part of this beneficial effect.

Key words: Apoptosis, ETA receptor antagonist (BQ-123), endothelin; NO, reactive oxygen radicals, rat

Med-Science. 2012; 1(4): 254-70

 

Metabolic Syndrome Prevalence in Childhood Obesity and Assesment of Obesity Related Conditions

Original Article

Metabolic Syndrome Prevalence in Childhood Obesity and Assesment of Obesity Related Conditions

Nilgün Çöl Araz, Ayşe Balat, Mustafa Araz

   

Abstract
Childhood obesity is an important risk factor fort he development of metabolic syndrome. The aim of this study was to assess the childhood obesity and the related conditions, to investigate the frequency of insulin resistance and metabolic syndrome and the possible related factors with these. The medical records of patients those referring to the Well-Child Outpatient Clinic of Gaziantep University, School of Medicine for routine health check-ups (medical examination) or to be vaccination were reviewed. 100 obese children, diagnosed according the International Obesity Task Force, included into the study. Relative weight ratio between 120-140 was classified as obesity, and a ratio above 140 was considered as morbid obesity. The average age of patients (55 female, 45 male) was 11.2 ±3.8 (3-17) years. Thirty three of the subjects were children and, 67 of them were adolescents. The 48% percent of the subjects were morbidly obese. Morbid obesity was higher in adolescents and in patients with a consanguinity between parents. Insulin resistance was determined 6.7% in children, 47.5% in adolescents. Free T4 levels were lower in patients with insulin resistance (p= 0.000). There was a negative correlation between fT4 and weight, body mass index and HOMA levels (p

Key words: Childhood, adolescent, obesity, metabolic syndrome

Med-Science. 2012; 1(4): 271-82

 

Rates and Risk Factors of Diabetic Foot Reamputations

Original Article

Rates and Risk Factors of Diabetic Foot Reamputations

Serkan Akçay, Ece Harman, İsmail Safa Satoğlu, Ahmet Kurtulmuş

   

Abstract
SUMMARY

Aim: The aim of this study is to determine the reamputation rate in patients who had amputation surgery in our hospital with the diagnosis of diabetic foot and to analyze the comorbid factors.

Material and Method: Of 131 patients with detailed information in their files 66 patients who had amputation surgery are included in the study. Age, gender, smoking habits, comorbid diseases, number, level, side and time period of amputation surgeries experienced, presence of infection, wound culture growth of microbes, presence of leukocytosis and method of treatment are recorded. Diabetic foot ulcers of the patients are graded with Wagner-Meggit classification depending on the depth of the wound. Wounds are also evaluated in three different pathophysiological groups as neuropathic, neuropathic-ischemic and ischemic. Levels of amputation were digital, ray, transmetatarsal, below-knee transtibial and above-knee transfemoral. Ipsilateral or contralateral reamputations in previosly amputated patients were investigated.

Results: Of the 66 patients who experienced amputation or reamputation surgery 45 were males and 21 were females. Mean age was 63,2 ( 26-88 ). 11 patients had reamputation surgery. 7 patients had ipsilateral reamputations at a more proximal level, 2 patients had contralateral side amputations and ipsilateral more proximal level reampuations and 2 patients had contralateral side amputations. Wagner-Meggit classification of the wounds in amputated patients yielded 4 Grade3, 40 Grade4, 11 Grade5 wounds where as 7 Grade4, 4 Grade5 wounds in reampuatated patients. Pathophysiological classification yielded 6 neuropathic, 21 neuroischemic and 28 ischemic wounds in amputation group where as 4 neuroischemic and 7 ischemic wounds in reamputation group.

Discussion: Evaluation of diabetes dependent and nondependent comorbid risk factors as well as the physiological capacity of the patients are important as much as selecting accurate level of amputation level with the aid of new diagnostic techniques in decreasing reamputation risk and rates.

Key words: diabet,foot,ulcer,amputation

Med-Science. 2012; 1(4): 283-91

 

Antitumor Activity of Propolis on Differantiated Cancer Cell Lines

Original Article

Antitumor Activity of Propolis on Differantiated Cancer Cell Lines

Neşe Ersöz Gülçelik, Dilara Zeybek, Figen Kaymaz, Ömür Gencay, Bekir Salih, Kadriye Sorkun, Aydan Usman, Esin Aşan

   

Abstract
Propolis is a natural bee product with several pharmacological activities. Nowadays, it is also investigated for its antitumor properties. There are contraversies on the antitumor activity of propolis, not all tumour cells seem to respond to propolis treatment. The aim of our study is to evaluate the activity of propolis on differantiated thyroid cancer cell lines. Tyripan blue test and MTT assay were performed to evaluate the cell viability of B-CPAP cells after propolis treatment and compared with propolis free cells and normal thyroid cells. Evaluation with light microscopy revealed after treatment with propolis, cell count decreased and B-CPAP cells displayed morphologic changes with a smaller appearance. Tyripan blue exclusion test showed a decrease in cell viability in different concentrations of propolis at 48 and 72 h. Cell viability was measured by MTT after the treatment of B-CPAP cells with propolis at 72 h. The decrease in cell viability was statistically significant only at 0.0001 diluted propolis (p=0.048). The decrease in cell viability in normal thyroid cell line was not statistically significant. In conclusion, propolis have weak antitumor activity on differantiated thyroid cell line which may contribute to different degrees of sensitivity of propolis among cancer cells.

Key words: Propolis, differantiated thyroid cancer, BCAP

Med-Science. 2012; 1(4): 292-300

 

Lichen Striatus on an Adult

Case Report

Lichen Striatus on an Adult

Arzu Ataseven, Perihan Ozturk, Ilknur Kucukosmanoglu

   

Abstract
Lichen striatus is a well-known, acquired, self-healing, linear inflammatory dermatosis. Its etiology remains unclear. It rarely affects adults, and it is characterized by abrupt onset of coalescent papules, in a linear disposition, usually on the extremities. It is usually localized and asymptomatic; however, when the onset occurs in adulthood, patients may experience widespread lesions and pruritus. The lesions are located on extremities and less commonly on the trunk, and they follow the developmental lines of Blaschko. Histopathology findings indicate both lichenoid and spongiotic dermatitis. The therapeutic approach usually used is topical steroids. It is reported here the case of an adult woman with erythematous violaceous papules on the left leg, diagnosed with lichen striatus by clinical and histopathological correlation.

Key words: Lichen striatus, blaschkitis, adult.

Med-Science. 2012; 1(4): 301-4

 

Relation of Serum 25 Hydroxy Vitamin D3 Levels with Insulin Resistance in Type 2 Diabetic Patients and Normal Subjects

Original Article

Relation of Serum 25 Hydroxy Vitamin D3 Levels with Insulin Resistance in Type 2 Diabetic Patients and Normal Subjects

Ahmet Cimbek, Gül Gürsoy, Nazli Gülsoy Kirnap, Yaşar Acar, Birsen Erol, Işil Özaşik, Fatih Güngör

   

Abstract
Hypovitaminosis D is supposed to be associated with diabetes mellitus and metabolic syndrome. Defects in pancreatic β cell function and/or insulin sensitivity are often present, to develop glucose intolerance or type 2 diabetes mellitus. There are accumulating evidence that vitamin D may influence these mechanisms. Aim of our study was to test the hypothesis of an association between hypovitaminosis D and insulin resistance in diabetic patients and normal subjects. We studied 101 type 2 diabetic patients and 60 controls. After detailed physical examination the venous blood was withdrawn, anthropometric measurements were taken, then an indirect measure of insulin resistance was calculated. Study population composed of diabetic and control groups. An indirect insulin resistance index was calculated and compared with other parameters including their 25 hydroxy vitamin D3 levels. In diabetic patients without insulin resistance; fasting blood glucose, fasting insulin and indirect insulin resistance index levels were significantly lower compared to diabetic patients with insulin resistance (p

Key words: Diabetes Mellitus, type 2, insulin resistance,vitamin D

Med-Science. 2012; 1(4): 305-14

 

Sleep Disturbances in Patients With Malignancy and Non-Malignancy

Original Article

Sleep Disturbances in Patients With Malignancy and Non-Malignancy

Hakan Atalay, Naz Berfu Akbas, Cengiz Pata, Basak Oyan Uluc

   

Abstract
Objective: Aim of the study was to evaluate sleep quality in a small sample of patients with gastro-esophageal reflux disease (GERD) comparing them with the patients under treatment in oncology department. Method: Forty-eight patients were included in the study, 22 of them were recruited from the oncology department (oncology patients: OnPs) and 26 from the gastroenterology department (gastroenterology patients: GEPs) at a university hospital. By senior psychology students, the Hospital Anxiety and Depression Scale and the Pittsburg Sleep Quality Index were administered to the patients. Results: There was no significant difference between the two groups regarding anxiety and depression scores of the patients and their total sleep quality scores. Nevertheless, it has been found that GEPs had higher anxiety scores than OnPs. Conclusion: The regression analysis demonstrated that sleep quality scores are determined only by anxiety scores and that being an oncology or gastroenterology patients, being at a certain age, or gender have no effect on total sleep quality scores.

Key words: Sleep, Gastro-esophageal reflux disease, Malignancy, Anxiety, Depression

Med-Science. 2012; 1(4): 315-22

 

Evaluation of Androgen Levels in Patients with Acute Coronary Syndrome

Original Article

Evaluation of Androgen Levels in Patients with Acute Coronary Syndrome

Fatma Dilek Dellal, Mutlu Niyazoğlu, Tamer Çeviker, Süheyla Görar, Ertuğrul Taşan

   

Abstract
Objectives: To determine plasma levels of free Testosterone (fT) and dehydroepiandrosterone sulphate (DHEA-S) in male patients with acute coronary syndrome.
Methods: We checked the serum fT and DHEA-S levels of 30 healty male subjects and 64 male patients with acute coronary syndrome whose coronary artery diseases were confirmed by coronary angiography.
Results: We observed no difference between two groups on the level of fT while DHEA-S level was significantly lower (p = 0.01). No correlation had existed between lipid parameters and levels of fT and DHEA-S.
Conclusion: More comprehensive studies are needed about whether lower levels of DHEAS in patients are contributed to acute coronary syndrome or are the effect of disease.

Key words: free testosterone, dehydroepiandrosterone sulphate, acute coronary syndrome, coronary artery disease

Med-Science. 2012; 1(4): 323-30

 

A Retrospective Analysis of Amputation Rates and Comorbidity in Patients with Diabetic Foot Ulcer

Original Article

A Retrospective Analysis of Amputation Rates and Comorbidity in Patients with Diabetic Foot Ulcer

Serkan Akçay, İsmail Safa Satoğlu, Ece Harman, Ahmet Kurtulmuş, Cemal Kazımoğlu

   

Abstract
Abstract
Diabetic foot ulcers cause elongated hospitalisations with high treatment costs and high rates of lower extremity amputations resulting with increased morbidity and decreased quality of life. The aim of this study was to determine amputation rate in patients admitted to our hospital with the diagnosis of diabetic foot and the most common risk factors in patients with diabetic foot ulcers. 131 patients admitted to outpatient clinics of Izmir Katip Celebi University Ataturk Training and Research Hospital between January 2011 and December 2011 with the diagnosis of diabetic foot ulcer were retrospectively analyzed. Of these 96 were males and 35 were females. Age, gender, smoking and alcohol habits, comorbid diseases, presence of infection, growth of microorganism in medium, presence of leukocytes, hypertension, method of treatment and regimes of antibiotics are recorded. Mean age was 61,1 ( 26-90). Patients are divided into two groups according to treatment protocols, first group was consist of debriated and medicaly treated patients, while the second group covered amputated patients. 66 were amputated and the rest 65 had debridement-wound care and antibiotherapy after they were evaluated in the diabetic foot council of our hospital. Rate of amputation was 50 %. 36 of the amputated patients had major and the others had minor amputations. Most common comorbidities that related and nonrelated to diabetes were peripheral arterial disease ( 102 out of 131; 77% ) and hypertension ( 50 out of 131; 38% ); respectively. Grading of diabetic ulcers according to Wagner-Meggit classification yielded that most commonly seen wounds were grade 4 in the amputation group and grade 2 in the debridement group. According to pathophysiological classification most common cause were ischemic wounds in both groups. Compared to the literature, our amputation rates are higher. This issue can be attributed to high rates of comorbid factors, higher age and irregular follow-up.
Key words: diabetic foot, amputation, comorbidity

Key words: Diabetic Foot; Amputation; Comorbidity

Med-Science. 2012; 1(4): 331-40