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Prevalence of tobacco use among Class 10 students in an urban field practice area, Bangalore: a cross sectional study

Original Article

Prevalence of tobacco use among Class 10 students in an urban field practice area, Bangalore: a cross sectional study

Malappurath Suresh Shruthi, Riyaz Basha, Selvi Thangaraj, Rangnath T S

   

Abstract
Objectives: To study prevalence and perception of tobacco use among 10th Standard students in an urban field practice area in Bangalore
Background: Smoking is the most widespread , modern social disease worldwide; and one “tobacco-related” death occurring every 8 seconds in India, whereas avoiding tobacco adds 20 yrs to the life of a teenager. Efficient preventive programs implemented among adolescents would considerably lower the morbidity and mortality in adults for chronic diseases.
Materials and methods: High schools of the urban field practice area were selected by simple random sampling. Data was collected by self-administering of pre-structured questionnaire to all Class 10 students of each of the selected schools.
Results: Overall prevalence of tobacco use was 17.9% .There was a statistically significant association between gender, parental influence and tobacco use among students (p

Key words: Key words: tobacco use, smokeless forms of tobacco, smoking, students

Med-Science. 2013; 2(1): 363-73

 
Medicine Science Vol:2 Issue:1 Year:2013 PP:363-499

The profile of pleural tuberculosis patients in Turkey

Original Article

The profile of pleural tuberculosis patients in Turkey

Aylin Babalık, Şule Kızıltaş, Korkmaz Oruç, Gülgün Çetintaş, Sinem Altunbey, Haluk Celalettin Çalışır

   

Abstract
Abstract
Background: Tuberculosis is the leading cause of exudative pleural effusion. The present study was designed to evaluate the patient profile in a 3-year cohort of pleural tuberculosis patients.
Methods: A total of 174 patients with pleural tuberculosis (mean(SD) age was 36.1 (17.3) years, 64.9% were males) followed up in our clinic from 2004 to 2007 were included in this study. Data on diagnostic methods, pleural fluid findings and clinical features of patients were recorded based on retrospective evaluation of the medical records. Diagnostic thorasynthesis was performed in patients with pleural effusion. Concomitant analysis of pleural fluid and blood biochemistry (glucose, LDH, protein levels), ADA values and cytology of pleural fluid were performed. Tuberculosis patients were categorized and treated in accordance with WHO guidelines. Patients were invited to attend monthly visits for the cohort analysis after discharge.
Results: The frequency of patients below and above 35 years of age was 51.1 and 48.9%, respectively. Parenchymal lesion was evident in 22.4% of patients while pleural fluid was detected in 50.6% of patients. Lymphocytic fluid was detected in 98%. Mean (SD) level for ADA in the pleural fluid was 76.9(41.2) U/L. Pleural biopsy revealed granulomatous infection in 53.8% and chronic pleuritis in 46.2% of patients. There was a significant relation of age over 35 years to presence of chronic infection in pleural biopsy (OR: 3.11 (1.33-7.23)) and co-morbid disorder (OR: 23.53 (5.33-103.93)). Pleural biopsy was performed in 38.2% of patients who were younger than 35 years while in 51.7% of patients who were older than 35 years. The frequency of granulomatous infection diagnosis was significantly higher in patients younger than 35 years when compared to older patients (54.8% vs. 45.2 %; p=0.02).
Conclusion: In our study including homogenous distribution of patients in terms of being younger and older than 35 years of age, pleural biopsy was performed more commonly in older patient in order to eliminate possible underlying malignancy. However the diagnostic power of pleural biopsy was determined to be poor. Accordingly, after elimination of other causes of the exudate development, initiation of tuberculosis treatment based on ADA and cell count results seems reasonable

Key words: pleural tuberculosis; patients profile; Turkey

Med-Science. 2013; 2(1): 374-85

 

7,7′-Bis[(aza-18-crown-6)carbonyl]thioindigo: Synthesis, Experimental, Theoretical Characterization and Biological Activities

Original Article

7,7'-Bis[(aza-18-crown-6)carbonyl]thioindigo: Synthesis, Experimental, Theoretical Characterization and Biological Activities

Metin Koparır

   

Abstract
This work presents the characterization of 7,7′-Bis[(aza-18-crown-6)carbonyl]thioindigo (I) by quantum chemical calculations and spectral techniques. The molecular geometry, frontier molecular orbitals (FMO), molecular electrostatic potentials (MEP) and nonlinear optical properties of I in the ground state have been calculated using the density functional method (B3LYP) with the 6−31G(d,p) basis set. The calculated results show that the optimized geometry can well reproduce the crystal structure. The predicted non-linear optical properties of I are greater than ones of urea. The title compound has been tested in vitro for biological effects. The title compound was found to exhibit significant antimicrobial and antioxidant activity

Key words: 7,7\’-bis[(aza-18-crown-6)carbonyl]thioindigo, dft, biological effects, mep

Med-Science. 2013; 2(1): 386-402

 

VDBP Gene Polymorphism in COPD

Original Article

VDBP Gene Polymorphism in COPD

Sadan Soyyigit, Onur Baykara, Nur Buyru, Muzeyyen Erk

   

Abstract
Chronic obstructive pulmonary disease (COPD) is a disease which genetic and environmental factors play an important role in COPD development. VDBP (Vitamin D Binding Protein ) gene might be responsible for COPD development. The purpose of this study to investigate the possible effect of VDBP on progression of COPD.
We studied VDBP genotypes in 75 COPD patients, 36 smoker healthy subjects and 19 non-smoker healthy subjects with PCR-RFLP method to analyze the association between VDBP and COPD. In our study, the most frequently seen genotype was 1S-2 with a frequency of 32% in COPD group; and 1F-1S genotype with a frequency of 33.3% in smoker healthy group. There was no significant difference between these genotypes. In our study groups, we did not find any 2-2 genotype in non-smoker healthy subject group while it has been found 4% and 8% in COPD and healthy smoker subject groups, respectively. Although we did not find any significant difference for protective effect of the 2 allele on the disease or susceptibility of 1F allele to COPD formation in COPD patients and smoker healthy subjects (p: 0.346, p: 0.249, respectively), the only significant difference was between the patient and the healthy non-smoker groups with 1S-1S genotype (p=0.032). Our results do not show any evidence that indicate a protective or susceptibility effect of VDBP 2 and 1F alleles in progression of COPD, respectively but results indicate that having the 1S-1S genotype may be associated with the etiology of COPD.

Key words: COPD, VDBP, genetic polymorphism, allele frequency

Med-Science. 2013; 2(1): 403-13

 

Pseudoaneurysm discovered during reverse radial forearm flap after a gunshot injury: a case report

Case Report

Pseudoaneurysm discovered during reverse radial forearm flap after a gunshot injury: a case report

Okan Aslanturk, Kadir Ertem, Mustafa Karakaplan, Mehmet Fatih Korkmaz

   

Abstract
Gunshots cause injury on the vascular wall by phsical forces and thermal effect. These injuries are minor intimal damage, complete or partial transaction of the vessel, arteriovenoous fistula and pseudoaneurysm. In this article we report a pseudoaneursym case, at a gunshot wound on right hand planned to repair by reverse radial forearm flap for to cover the defect occured at the ipsilateral dorsum of the right hand, which was suspected on CT angiography but missed out preoperatively and seen in surgery during exploration and reparied.

Key words: Gunshot wound , hand injury, pseudoaneurysm, radial forearm flap

Med-Science. 2013; 2(1): 414-22

 

Adjuvant Use of Melatonin with Fluoxetine for Management of Fibromyalgia

Original Article

Adjuvant Use of Melatonin with Fluoxetine for Management of Fibromyalgia

Saad Abdulrahman Hussain, Ihab Ibrahim Alkhalifa, Nizar Abdullateef Jassim

   

Abstract
Fibromyalgia (FMS) is a chronic musculoskeletal disorder characterized by generalized muscular pain and tenderness at specific anatomical sites. Although melatonin was effective in treating the pain associated with this syndrome, no defined clinical evidence supports this claim. The present study was designed to evaluate the clinical significance of using melatonin, alone or in combination with fluoxetine in FMS. A double-blind clinical study was conducted on 45 patients with FMS randomized into 4 groups; group A, treated with fluoxetine 20mg/day alone; group B, treated with melatonin 5mg alone; group C, treated with combination of fluoxetine 20 mg+3 mg melatonin; group D treated with combination of fluoxetine 20 mg+5 mg melatonin. Both fluoxetine and melatonin were given once daily in the morning and night time respectively for 8 weeks. Each patient clinically evaluated using Fibromyalgia Impact Questionnaire (FIQ). Serum levels of serotonin, malondialehyde and nitric oxide were also evaluated. Using melatonin (3 and 5mg/day) in combination with 20mg/day fluoxetine significantly decreased total FIQ score values; the combination therapy significantly decreased serum serotonin level associated with reduction in the oxidative stress parameters (MDA and NO). In conclusion, adjuvant use of melatonin with fluoxetine improves the biochemical and clinical parameters of FMS patients.

Key words: Fibromyalgia; Oxidative Stress; Serotonin; MDA; Nitric oxide

Med-Science. 2013; 2(1): 423-35

 

Serum and Amniotic Fluid Eosinophil Cationic Protein Levels in Misoprostol Induced Pregnancies

Original Article

Serum and Amniotic Fluid Eosinophil Cationic Protein Levels in Misoprostol Induced Pregnancies


Nilufer Celik, Nursel B. Oztekin, Onder Celik, Halil Ibrahim Ozerol

   

Abstract
Objectives: The aim of this study was to determine the concentration of eosinophil cationic protein (ECP) in maternal serum (MS) and amniotic fluid (AF) at term and assess misoprostol induced changes in their mean concentrations.
Methods: A total of 53 pregnant women were included in the study: 24 were in active labor, and a further 29 were not in labor and misoprostol induction was performed. The initial 3 mL of amniotic fluid was collected and processed. In all pregnant subjects, maternal blood samples were obtained from the cubital vein at the time of amniotic fluid sampling. The concentration of ECP in serum and AF was measured by chemiluminescence method with the immulite 2000 analyzer (Immulite2000® ECP, DPC Diagnostic Products Corporation 5700 West 96th Street Los Angeles, CA, USA).
Results: Misoprostol induced pregnant showed significantly higher concentrations ECP than the control pregnant women in serum. AF-ECP concentrations were not significantly different between two groups. There was no significant difference between MS and AF-ECP concentrations in control subjects.
Conclusion: The association we encountered between labor induction with misoprostol and increased systemic production of ECP should be investigated further.

Key words: Misoprostol; Amniotic fluid; Serum; Cervical ripening

Med-Science. 2013; 2(1): 436-44

 

Isolated fracture of the fibular shaft due to alpine skiing; a specific injury

Case Report

Isolated fracture of the fibular shaft due to alpine skiing; a specific injury

Halis Atıl Atilla, Ozkan Kose, Ferhat Guler, Hayati Aygün, Cemil Yıldız

   

Abstract
Although musculoskeletal injuries of lower leg due to alpine skiing is well known and widely reported, an acute isolated fibula fracture as a specific ski injury has not been reported in the relevant literature. Herein, we present a case of isolated fibula fracture which is missed at initial admission, and discuss the mechanism of injury and relationship with alpine skiing equipment.

Key words: Alpine skiing, skiing injuries, fibula, fracture

Med-Science. 2013; 2(1): 445-9

 

A Sexually Abused Child Who Committed Suicide: Case Report

Case Report

A Sexually Abused Child Who Committed Suicide: Case Report

Fatma Yücel Beyaztaş, Celal Bütün, Fulya Feride Çağlar, Bahadır Özen

   

Abstract
The sexual abuse of children is defined to be used for sexual satisfaction of an adult. In this case report forensic, and medical files of a 16-year-old girl who had committed suicide by drug overdose were investigated. It is learned that about 18 months ago she had began to date with her 20-year-old boy friend from the same village. At the beginning mutual tolerance, and willingness governed their love affair. However for the previous year she had been forced, threatened, and kidnapped for sexual intercourse. She had told that she couldn’t break up her relationship because of his fearful, and insulting threats, and subsequently she had been a victim of frequent sexual assaults. Finally, while she had been forced, and retained for a sexual intercourse in the barn, her family informed the legal authorities of her absence. When she had been found, she had declared that her boy friend gave him a glass of cola drink, and battered her on the neck, so she couldn’t recall everything fully. Her physical examination revealed signs of trauma on her head, and extremities, and her psychological, evaluation demonstrated a disordered mental health state because of sexual assaults she had been exposed to. She had been hospitalized in a psychiatry clinic, and discharged in ten days.
Five days after her discharge from the hospital, she attempted suicide by swallowing 24 different kinds of tablets routinely used by her grandmother. According to hospital records, despite appropriate treatment she had a cardiac arrest and died. It was concluded that the victim who had a history of sexual assault nearly two weeks ago, had died of visceral organ bleeding, and cardiac arrhythmia due to intake of multiple drugs with the intent of committing suicide.
The abuse case among the risky groups for suicide is an important public health problem. About the prevention of the sexual abuses and the suicides; education, treatment, social rehabilitation should be provided, and the safety precautions must be taken.

Key words: Child, abuse, sexually abuse, suicide, forensic medicine.

Med-Science. 2013; 2(1): 450-3

 

Investigation of Possible Genotoxic and Cytotoxic Effects of Differential Boron Compounds in CCL 62 (Hela Contaminant) Human Amniotic Ephitelial Cell Line

Original Article

Investigation of Possible Genotoxic and Cytotoxic Effects of Differential Boron Compounds in CCL 62 (Hela Contaminant) Human Amniotic Ephitelial Cell Line

Erkan Kahraman, İsmet Deliloğlu Gürhan, Mehmet Korkmaz

   

Abstract
Epidemiological and in vitro studies have showed that boron may have anti-carcinogenic properties. Chromosome aberrations assay and sister chromatid exchange assays have showed that boron has no genotoxic effects on cytogenetically stable cell lines. Aim of this investigation is determine to effects of different boron compounds which are boric acid (BA), borax pentahydrate (BP) and disodium pentaborate decahydrate (DPD) ) on exist cytogenetic disruption with variable doses (250, 500 and 1000µM ) on cytogenitically unstabel CCL 62 (HeLa Contaminant) cell line. In order to test this hypothesis, following the boron treatment on the cell lines for cytotoxcity was performed using MTT that cell viability assay. For genotoxicity was used chromosome aberrations assay (CAs) and micronucleus assay (MN), CAs and MN frequency calculated in each boron dose.
Boron compaunds effected proliferation of CCL 62 (human amniotic ephitelial) cell lines in a time, species and dose dependent manner. According to data obtained from CAs and MN assays, no significant difference was found between control groups which were not treated any of boron compaund with boron treated groups (p>0,05).
In conclusion, we established that BA, BP, and DPD effected proliferation of CCL 62 cell lines in a time, compaund and dose dependent manner, however no evidence was observed suggesting these compounds cause an increase or decrease in the level of existing cytogenetic defects in these cell lines.

Key words: Boron, Boric acid, Borax pentahydrate, Disodium pentaborate decahydrate, Cytotoxicity, Genotoxicity

Med-Science. 2013; 2(1): 454-68