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Cholesterol Lowering Effect of Subchronic Inhalation Particulate Matter 10 Coal Dust on Rats

Original Article

Cholesterol Lowering Effect of Subchronic Inhalation Particulate Matter 10 Coal Dust on Rats

Bambang Setiawan, Asnawati Darsuni, Fauzan Muttaqien, M Aris Widodo

   

Abstract
Aim of this study was have to known an effect of inhaled particulate matter 10 (PM10) of coal dust on lipid profile, hematopoetic stem cells (HSC) and circulating endothelial cells (CECs) in rats. A total of 32 Wistar male rats, were randomly divided into four groups of 8 rats each, including one control group and three groups for inhaled coal dust (concentration 6.25 mg/m3; 12.5 mg/m3; and 25 mg/m3). The exposure to coal dust exposure was conducted using equipment that was designed by and available from Pharmacology Laboratory, Medical Faculty, Brawijaya University of Malang. The level of total cholesterol was lower significantly in rats inhaled to coal dust at compared with the control rats (p

Key words: dyslipidemia; inhaled pollution; endothelial damage; hematopoetic stem cells.

Med-Science. 2013; 2(2): 500-11

 
Medicine Science Vol:2 Issue:2 Year:2013 PP:500-648

Awareness of Diabetic Patients About Their Illness and Associated Complications in Ethiopia

Original Article

Awareness of Diabetic Patients About Their Illness and Associated Complications in Ethiopia

Sadikalmahdi Hussein Abdella, Mohammed Adem Mohammed

   

Abstract
Diabetes mellitus is the commonest of all metabolic diseases all over the world, as it is as well in Ethiopia. At present it is estimated that about 150 million people are affected by diabetes mellitus worldwide. In Ethiopia diabetes is being recognized as one of important health problem. Diabetes mellitus is associated with chronic complications like neuropathy, nephropathy, retinopathy and cardiovascular disease. Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. To assess the awareness of diabetic patients about their illness and associated complications in Ethiopia. Institutionbased cross sectional study was conducted in Tertiary care hospital Ethiopia. Current medication use data were collected by reviewing patients’ charts in the diabetic care follow up clinic and by interviewing diabetic patients who were on follow-up during data collection period using semi-structured questionnaire in Jimma University Specialized Hospital (JUSH). A total of 118 diabetic patients were included in the study. 53 (44.92%) of the respondents did not know the type of diabetes they were inflicted with, of those who know the type,40 (33.90%) of respondents were type II and 25 (21.20%) were type I. Incidental finding, or medical checkup as the main cause of first presentation with the disease was 61(51.69%) respondents. 52(61.18%) patients replied that meal omission is the main cause for developing acute complications, followed by insulin omission. 80 (67.79%) had knowledge about long-term complications. Majority of patients had good knowledge on actions to be taken on occurrence of acute complications and reasons for developing acute complications. In order to increase patient’s awareness, health care providers should provide regular diabetic education for patients during follow-up and pamphlets should be prepared and distributed consistently.

Key words: Awareness, complications, diabetes

Med-Science. 2013; 2(2): 512-22

 

HIV and Preconception- a Review

Original Article

HIV and Preconception- a Review

Divya Hegde, Priya Kamath, Latha Sharma

   

Abstract
In the recent past there has been a significant improvement in the quality of life and vast reduction in Human Immunodeficiency Virus- related mortality rates. The advent of antiretroviral therapy has largely contributed to this drastic increase in the life expectancy of Human Immunodeficiency Virus -infected individuals. In this review we have discussed about fertility issues in -infected people, preconception, fertility desires, effect of Human Immunodeficiency Virus on pregnancy, factors affecting mother to child transmission, diet and advice in pre-conception, behavioural and psychological support, impact of preconception services and areas of future researches. Method- A internet based PUBMED, MD CONSULT, Science direct and African journals online search of all the articles dating from 1998 to 2012 available under the heading of Human Immunodeficiency Virus and preconception was carried out and a detailed review was presented.

Key words: Preconception, pregnancy, HIV, nutrition, fertility

Med-Science. 2013; 2(2): 523-38

 

Should FISH Test be Performed to all Patients With Breast Cancer?

Original Article

Should FISH Test be Performed to all Patients With Breast Cancer?

Hasan Mutlu, Halit Karaca, Zeki Akca, Yasemin Altuner Torun, Abdülsamet Erden, Tuncay Aslan, Abdullah Büyükçelik

   

Abstract
CerbB2 receptor determination is very important for the prognosis and treatment of breast cancer. The most used two methods for CerbB2 receptor determination are immunohistochemistry and FISH methods. FISH method is recommended for immunohistochemically CerbB2 (++) patient group. Therefore, even though the immunohistochemically CerbB2 (++) patients are in the same group, FISH test divides the results into two separate groups. Our study compared these two groups in terms of relaps duration. Total of 85 patients from The Kayseri Research and Training Hospital in Kayseri, Kayseri Erciyes University Hospital and Mersin State Hospital were included in this study. The relaps duration of the patients were determined and then compared statistically. When the mean disease free survival was compared for FISH(+) and FISH(-) groups, the mean DFS was 46±5 and 73±8 months. However, the median DFS was 38±9 months for the FISH positive group. No median PFS was reached for FISH (-) group. Immunohistochemically CerbB2 (++) breast cancer patients are considered as in the same group, however actually they have different prognostic features. Similarly, when the immunohistochemical tests and FISH tests are compared for CerbB2 positivity, different results are obtained. As a consequence of that, the therapy alternatives will be changed. Therefore, we conclude that the FISH test should be performed to all patients.

Key words: Breast cancer, FISH, Cerb B2 (++), HER 2

Med-Science. 2013; 2(2): 539-47

 

Assessment the Levels of Knowledge and Awareness about Organ and Tissue Donation among The Staff of Ministry of Health Ordu University Training and Research Hospital

Original Article

Assessment the Levels of Knowledge and Awareness about Organ and Tissue Donation among The Staff of Ministry of Health Ordu University Training and Research Hospital

Özgür Enginyurt, Nilay Taş, Erdal Özer

   

Abstract
The aim of this study is to determine the level of knowledge and awareness about organ and tissue donation among the staff from Ordu University Education and Resarch Hospital. The 25 item questionaire was prepared and administered to 297 person who accepted to participate in the study. At the end of the study age, sex, and educational level did not change the status of being organ donors. But also thinking about organ donation was unchanged between different age groups, genders, and educational levels. The aim of this study is also to attract attention to the organ and tissue donation and also to raise awareness about this issue. Study has laid out that the level of staff knowledge about organ and tissue donation and also staff interest are not enough. The subject should be reminded to all society starting from health professionals. The importance of organ donation must be emphasized more often in the media.

Key words: tissue, organ, donation

Med-Science. 2013; 2(2): 548-56

 

Seasonal Admission Rates of Geriatric Patients with Musculoskeletal Problems to Physical Therapy and Rehabilitation Clinics

Original Article

Seasonal Admission Rates of Geriatric Patients with Musculoskeletal Problems to Physical Therapy and Rehabilitation Clinics

Zubeyir Sari, Saadet Ufuk Yurdalan, Mine Gulden Polat, Bahar Ozgul, Ayfer Kanberoglu, Selma Onel

   

Abstract
Seasonal variations in the admission rates of geriatric patients with musculoskeletal problems to physical therapy and rehabilitation clinics were examined in this study. Totally 2257 patients (1802, 79.84% female; 455, 20.16% male) over the age of 65 years (mean age 72.32±5.67years) who were admitted to Duygu Private Hospital and Burcu Private Physical Therapy Branch Center in Istanbul were included. Monthly admissions and seasonal distribution were retrospectively calculated for 2 years. Admission rates of females were higher than for males in all seasons; females presented mostly in spring (33.1%), whereas males presented mostly in autumn (30.3%). Examination of monthly and seasonal admission identified gender-based differences according to months (p=0.007) and seasons (p=0.018). Monthly and seasonal admission rates according to age groups showed similar distribution of monthly (p=0.406) and seasonal (p=0.327) admissions. These findings suggest that, due to climatic conditions in Istanbul, seasons with significant temperature changes affected musculoskeletal symptoms and that future studies should further analyze this subject.

Key words: Geriatrics, musculoskeletal diseases, physical therapy, seasonal variation

Med-Science. 2013; 2(2): 557-63

 

Intraoperative Anaphylactic Shock Due To Latex Allergy: Case Report

Original Article

Intraoperative Anaphylactic Shock Due To Latex Allergy: Case Report

Mustafa Said Aydogan, Ulkü Ozgül, Mehmet Ali Erdoğan, Nurcin Gülhas, Hüseyin Ilksen Toprak, Mahmut Durmus

   

Abstract
Anaphylaxis is an acute and fatal systemic allergic reaction to an allergen, and it can be an unpredictable and life threatening during anesthesia. Latex is the second most common cause of anaphylaxis following the neuromuscular blocking agents during general anesthesia or surgery. We present a case of an anaphylactic reaction that 42-year-old male patient, with a diagnostic suspicion of appendicitis, who underwent an emergency surgery under general anesthesia. Prevention, diagnosis, treatment, and follow-up of patients affected by this event was represented for anesthesiologists. The aim of this report was to describe a case of severe latex induced anaphylactic reaction and discuss its diagnosis and treatment.

Key words: latex,anaphylaxia, anesthetetic management

Med-Science. 2013; 2(2): 564-8

 

Relationship of Glutathione Status with Oral Pre-cancer and Cancer

Original Article

Relationship of Glutathione Status with Oral Pre-cancer and Cancer

Shishir Ram Shetty, Subhas G Babu, Sucheta Kumari, Pushparaja Shetty, Radhakrishna Vijay, Arvind Karikal

   

Abstract
Oral cancer accounts for the majority of the cancer in South East Asian region and especially in the Indian subcontinent. If diagnosed at an early stage the disease is reported to have a better prognosis. Sialochemistry involving antioxidants has recently gained importance for oral cancer risk assessment because of its non-invasive nature. The aim of this study was to estimate the levels of glutathione in saliva of patients with oral cancer, oral leukoplakia and healthy controls. Three study groups comprising of, 25 oral cancer patients, 25 oral leukoplakia patients and 25 healthy controls were involved in the study. Saliva sample collected from the patients were evaluated by Beutler’s method. The data obtained were analyzed using the one way ANOVA test. There was a significant difference between the levels of salivary glutathione in between oral cancer, oral leukoplakia groups when compared to healthy controls. The levels of salivary glutathione were lower in oral cancer when compared to oral leukoplakia but the difference was not statistically significant. The results suggest that salivary gluthione level estimation could be used for determine the risk of oral cancer as a non-invasive modality.

Key words: Saliva, glutathione, oral cancer, leukoplakia.

Med-Science. 2013; 2(2): 569-74

 

Investigating the Efficacy and Safety of Silymarin in Management of Hyperbilirubinemia in Neonatal Jaundice

Original Article

Investigating the Efficacy and Safety of Silymarin in Management of Hyperbilirubinemia in Neonatal Jaundice

Lamyaa M. Kassem, Mohamed EA Abdelrahim, Hassan F. Naguib

   

Abstract
Unconjugated hyperbilirubinemia (UCB) is one of the most common conditions in neonates. Conventional treatment consists of phototherapy and exchange ‎transfusion. Phototherapy is safe and effective but it has several disadvantages. Exchange ‎transfusion is associated with a significant morbidity and even mortality. That indicates the need to ‎develop an alternative pharmacological treatment strategies. It should be less invasive and at least as ‎effective and safe as phototherapy. Herbal therapy has recently received special attention. Silymarin herbal drug has laxative, antioxidant, anti-inflammatory, hepatic protective, regenerative and enhancing of glucoronidation activities.
The study presented here aimed to investigate effect of Silymarin on duration of phototherapy. A prospective cohort trial performed on 170 full term healthy neonates with UCB, 85 received oral 3.75mg/kg of Silymarin twice daily plus phototherapy and 85 neonates received only phototherapy. Total serum bilirubin (TSB) was measured every 24h, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and albumin were measured before and after therapy for both groups. The mean duration of phototherapy was found to be significantly reduced from 5.3 ± 0.82 days in the control group to 4.2 ± 0.76 days in Silymarin-treated group (p=0.001). ALT, AST are improved to normal levels significantly (p=.001) also albumin (p=0.005).
Silymarin dose of 3.75mg/kg twice daily along with phototherapy was more effective than phototherapy alone in treating full term healthy neonates with UCB.

Key words: silymarin, neonatal jaundice, hyperbilirubinemia, phototherapy, bilirubin.

Med-Science. 2013; 2(2): 575-90

 

The Effect of the Serum Amino Acid Levels Thiosemicarbazone Derivatives and its Metal Complexes on Rats

Original Article

The Effect of the Serum Amino Acid Levels Thiosemicarbazone Derivatives and its Metal Complexes on Rats

Mustafa Karatepe, Dilara Kaman

   

Abstract
Advers biological activities of Thiosemicarbazone (TSC) and Schiff base (SB) derivatives have been widely studied in rats and in other animal species using different doses, times and routes of administration. To date, no attempt has been made to study alterations occurring in the amino acid profile in the effects of the thiosemicarbazone derivative and its metal complexes on the rats. At this study, the rats were injected subcutaneously with a new thiosemicarbazone and its LH-Zn and LH-Cu complexes (25 mg/kg body weight) and then sacrified after 15th days. The aim of this study was to determine the effect of new compounds on the serum amino acid levels in rats. In the comparision done among groups, it was observed that serum amino acid concentrations were statistically changed (p < 0.05).

Key words: Thiosemicarbazone, metal Complex, amino acid

Med-Science. 2013; 2(2): 591-600