Menü Kapat

The Relationship between Obesity and Oxidative Stress and Cardiac Markers

Original Article

The Relationship between Obesity and Oxidative Stress and Cardiac Markers

Pinar Baki Unver, Aysun Bay Karabulut, Ayse Cikim Sertkaya, Tugba Raika Kiran, Julide Yagmur

   

Abstract
Obesity is one of the most even leading issue for the last era but however the reasons for this epidemic could not been explained clearly yet. We aimed to investigate the relationship between obesity, and myoglobin and homocysteine in means of cardiac markers and the levels of nitric oxide in means of oxidative stress and leptin. Study populations consisted of 30 patients with obesity and 30 healthy volunteers as control group. Serum nitric oxide, homocysteine, leptin and myoglobin were higher in obese individuals compared to controls. Nitric oxide level was related to myoglobin levels and seems to alter the myoglobin concentration. A negative and strong correlation was defined for myoglobin with both gender and age. There was a positive correlation between Body Mass Index and homocysteine. This is one of the studies investigating the relationship between nitric oxide as an oxidation marker homocysteine and myoglobin as cardiac markers, and leptin with obesity to lighten the complex relationship for the issue.

Key words: Obesity, nitric oxide, leptin, myoglobin, homocysteine

Med-Science. 2015; 4(2): 2087-97

 
Medicine Science Vol:4 Issue:2 Year:2015 PP:2087–2355

The Treatment and Follow up of Adrenocortical Carcinoma [Adrenokortikal Karsinomlarda Tedavi Ve Izlem]

Original Article

The Treatment and Follow up of Adrenocortical Carcinoma [Adrenokortikal Karsinomlarda Tedavi Ve Izlem]

Pinar Sisman, Canan Ersoy

   

Abstract
Adrenocortical carcinoma is a rare endocrine malignancy. Patients present with hormone excess or a local mass effect. The tumor is agressive and characterized by a high risk of recurrence even after complete resection. Recurrence rate (particularly local recurrence) is higher in laparoscopic adrenalectomy and most recurrences occur in the postoperative first two years. Because of the high recurrence rates, most patients need adjuvan treatment after radical resection. Three adjuvant therapotic approach have been suggested: Mitotane, mitotane plus chemotherapeutic agents and radiotherapy of the tumor bed. Adjuvant mitotane is the first line medical treatment but it is associated with some adverse events and in all patients a strict follow up is required because of the drug’s narrow therapeutic index. Adverse events are manageable through reduction of the mitotane dose. Patients with adrenocortical carcinoma should be followed up regularly at least 10 years after radical surgery.

Key words: Adrenal cancer, treatment, surgery, mitotane, chemotherapy, radiotherapy

Med-Science. 2015; 4(2): 2098-108

 

A Simple New Classification for Diabetic Foot Ulcers

Original Article

A Simple New Classification for Diabetic Foot Ulcers

Amit Kumar C Jain

   

Abstract
Gangrene, infections like abscesses and ulcers are some of the common diabetic foot complications. Of all these, diabetic foot ulcers pose a major public health problem. Around 80% of all the lower limb amputations are preceded by a foot ulcer. There are various classifications for diabetic foot ulcers out of which the two commonly used classifications are Wagner’s ulcer classification and the classification of University of Texas. The author proposes another simple new classification specific for diabetic foot ulcer which is one of the common diabetic foot complication. This classification is an addition to the author’s already existing new classifications on various aspects of diabetic foot so that a new Amit Jain’s principle and practice of diabetic foot could be devised for improvising and standardizing the practice of diabetic foot. According to this new classification, diabetic foot can be clinically classified into 3 simple classes.

Key words: Diabetic foot, ulcer, new classification, Amit Jain’s, Wagner’s

Med-Science. 2015; 4(2): 2109-20

 

Role of HLA-A in Handedness

Original Article

Role of HLA-A in Handedness

Talib Muhsin, Batool Mahdi, Hayam Raouf, Hayder Hashim, Laheeb Abid, Zena Nihad

   

Abstract
A relationship exists between cerebral dominance and right or left handedness. Left-hemisphere dominance occurs in 97% of right-handed people and in 70% of left-handed people. The other 30% of left-handed individuals have anomalous or right-hemisphere dominance. Both environmental and genetic factors have been proposed to explain the human handedness. Aim of this study was to determine the effect of genetic factor of human leukocytes antigens (HLA-A) on development of left handedness. A cross-sectional case control comparative study included thirty Iraqi Arab Muslims individuals with left handedness between September -2013 to June -2014. The second control group consisted from thirty individuals with right handedness. HLA-A typing was done to both groups using SSOP method. There was no significant difference between different alleles regarding HLA-A left handed compared with the control group. Genetic factor regarding HLA-A typing had no role in development left handedness.

Key words: HLA, handedness, genetic

Med-Science. 2015; 4(2): 2121-7

 

Comparative Study of Oral Daily Amoxicillin, Long Acting Intramuscular Penicillin, and Tonsillectomy in Prevention of Recurrent Pharyngitis

Original Article

Comparative Study of Oral Daily Amoxicillin, Long Acting Intramuscular Penicillin, and Tonsillectomy in Prevention of Recurrent Pharyngitis

Amira S Ahmed, Engy A Wahsh, Essam Eldin G. Ahmed

   

Abstract
Pediatric recurrent pharyngitis represents a huge global health burden causing much morbidity and mortality in children. The aim of the study was to compare the efficacy of oral daily amoxicillin, intramuscular penicillin, and tonsillectomy in reducing the incidence of recurrent pharyngitis Between July 2012 and June 2013, a total of 100 paediatric patients (56 males and 44 females) diagnosed with recurrent pharyngitis were enrolled in the study. The clinical criterion for study entry was three or more episodes of pharyngitis in six months. The selected patients’ clinical data were recorded and a throat swab was obtained. Patients were divided randomly into three groups A, B, and C. Group A received a monthly ten days course of oral amoxicillin suspension (25mg/kg/day) for six months, group B received a single dose of intramuscular benzathine penicillin G every 3 weeks for 6 months and group C included patients who undergo tonsillectomy. All patients were scheduled for a monthly follow-up visit, during which they the number of recurrent pharyngitis episodes, compliance, adverse events and drug tolerability were assessed. All treatment regimens significantly decreased recurrences. While oral amoxicillin and IM penicillin efficacy were comparable, tonsillectomy was similarly effective to IM penicillin treatment and more effective than oral amoxicillin therapy. The once daily oral amoxicillin is a safe, effective and convenient alternative to IM penicillin in reducing the incidence of recurrent pharyngitis. Tonsillectomy is also a suitable alternative, however its possible related morbidity and mortality should be considered.

Key words: Recurrent pharyngitis, prevention, amoxicillin, intramuscular benzathine penicillin G

Med-Science. 2015; 4(2): 2128-42

 

A Study on the Prevalence of Prehypertension and Hypertension and its Association with Obesity in Adolescents [Adölesanlarda Prehipertansiyon ve Hipertansiyon Prevalansı ile Obezite Arasındaki İlişkinin İncelenmesi]

Original Article

A Study on the Prevalence of Prehypertension and Hypertension and its Association with Obesity in Adolescents [Adölesanlarda Prehipertansiyon ve Hipertansiyon Prevalansı ile Obezite Arasındaki İlişkinin İncelenmesi]

Hasan Huseyin Cam, Fadime Ustuner Top

   

Abstract
The obesity and hypertension are the major risk factors of several life threatening diseases. Despite an increasing prevalence of obesity and hypertension in young age, there is limited information on the contribution of body mass index (BMI) to blood pressure in these populations, especially in developing countries. This study aimed to determine the prevalence of high blood pressure and the associated risk of obesity among adolescents. A school-based cross-sectional study was conducted during January to February 2014 in Piraziz, Giresun, including total 1,362 adolescents. Socio-demographic profile anthropometric and blood pressure readings were obtained. Weight, height and blood pressure (BP) were measured using standard methods. Body mass index (BMI) was calculated and categorized by age, sex and percentile. Obesity and overweight were defined as: ≥ 95th and 85th to < 95th percentiles, respectively, for age, sex and height. Significance was set at P < 0.05. A total of 1,109 students (mean age 16,09 ±1,20 years), were assessed. The prevalence of hypertension and prehypertension was 2,3% and 2,0% respectively. The prevalence of overweight and obesity were 15,4% and 16,7%, respectively. Blood pressure was associated with body mass index. In this study, obesity was an important risk factor for hypertension. The high prevalence of hypertension in overweight and obese children emphasizes the need for prevention and control of childhood obesity and hypertension in early stages. Early lifestyle modification and a strengthened school health are recommended.

Key words: Adolescent, hypertension, prehypertension, obesity

Med-Science. 2015; 4(2): 2143-54

 

Dosimetric Evaluatıon of The Tomotherapy, Non-coplanar and Coplanar IMRT Plannings for Total Scalp Irradiation

Original Article

Dosimetric Evaluatıon of The Tomotherapy, Non-coplanar and Coplanar IMRT Plannings for Total Scalp Irradiation

Songul Barlaz Us, Esil Kara, Asli Yazici, Bahar Dirican, Eda Kaya Pepele, Simay Gurocak

   

Abstract
In this study, the dosimetric effects of the Tomotherapy, noncoplanar and coplanar IMRT plannings were evaluated for the total scalp irradiation. Tomotherapy based and linac based IMRT plans were compared for 61 years old female patient with multipl myeloma. Two different linac based IMRT plans which are coplanar and noncoplanar were performed for total scalp irradiation. 20 Gy was given to the PTV volume. Firstly, homogeneity index and conformity index values were calculated for PTV. Secondly, the doses of organ at risk (OaR) which are lenses, brain, brainstem and parotid glands were dosimetrically evaluated. While, tomotherapy plan was more homogenous, noncoplanar plan was more conformal than the others. Our study figure out that the OaR doses can be decreased by using tomotherapy based IMRT. However, the treatment time was increased when the tomotherapy based IMRT used for treatment. Tomotherapy based IMRT can be used for total scalp irradiation with respect to OaR.

Key words: IMRT, tomotherapy, coplanar, noncoplanar, OaR

Med-Science. 2015; 4(2): 2210-23

Wound Infection Rates and the Results of Antibiotic Susceptibility Tests in Severely Burned Patients

Original Article

Wound Infection Rates and the Results of Antibiotic Susceptibility Tests in Severely Burned Patients

Mithaq Khider, Mazin ameen, Batool Mahdi

   

Abstract
Background: Infection of burn wound is an important cause of mortality in burns Units in hospitals. The types of bacterial isolates and rapidly emerging antibiotics resistance are important factor in treatment of patients.
Aim of study: To demonstrate the types of bacterial isolated from burns and antibiotics resistance.
Patients and methods: A cross –sectional case control study included 220 Iraqi Arab Muslims patients who had burn (third degree) and admitted in the burn Department at Al-Kindy teaching Hospital between January – 2013 to June – 2013 . Age of the patients group was ranged from 1-70 years . Females were 124 and the rest were males. Swabs from burn area were collected and cultured on Blood Agar (Oxoid) and MacConkey Agar (oxoid) and other swabs were collected for Gram staining. Identification of bacteria and antibiotic susceptibility test were done using VITEK 2 Compact Device ( Biomeruiex Company –France).
Results : This study showed that burn is more common in females than males and females with infected burn (28.63%) were more common than males (11.36%). Klebsiella pneumonia is the most frequent bacterial isolated from burn (44%) and in both sexes , females and males , 41% and 45.56% respectively from burn patients. Klebsiella pneumonia is the most frequent bacterial isolated from burn (80.9%). Pseudomonas aeruginosa is also resistance to these antibiotics (93.75%). Acinetobacter spp. and Bruckholderia spp.were also resistance to gentamycine ,Ceftriaxone and Cefotaxime (100%). In case of Grame + bacteria , Staphylococcus aureus was resistance to impenime (90.75%) and Enterococcus fecalis is resistance to all antibiotics.
Conclusions: Klebsiella pneumonia is the most frequent bacterial isolated from burn and it is the most frequent bacterial isolated from burn.

Key words: Burn, infection, antibiotics

Med-Science. 2015; 4(2): 2165-71

 

Is Irisin an Anticarcinogenic Peptide?

Original Article

Is Irisin an Anticarcinogenic Peptide?

Suat Tekin, Yavuz Erden, Suleyman Sandal, Bayram Yilmaz

   

Abstract
Prostate cancer is the most common type of cancer in males. There has been currently no therapy to cure various types of cancer, and hence, studies aiming to develop cancer treatment are important and have been ongoing. Irisin is a hormone, which regulates body weight and metabolism, including insulin resistance and is thought to have beneficial effects on the properties of antiobesytetic. It is known that obesity is a risk factor in the development of cancer and at the present time, the effects of peptides on cancer thay may reduce obesity have been investigated. This study was carried out to investigate whether there is a role of irisin on human prostate cancer cell viability. In the present study, 0.1, 1, 10 and 100 nM concentrations of irisin were separately applied to human prostate cancer cells with androgen receptor positive (LNCaP) and androgen receptor negative (DU-145, PC3). Effects of irisin on prostate cancer cells were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. At the end of study, all concentrations of irisin reduced the viability of all three prostate cell types, but only 10 and 100 nM concentrations of the irisin caused a significant decrease (p

Key words: Irisin, LNCaP, DU-145, PC3, cell viability

Med-Science. 2015; 4(2): 2172-80

 

Clinical and Demographic Characteristics of 78 Patients with Adrenal Incidentaloma [Adrenal İnsidentalomalı 78 Hastanın Demografik ve Klinik Özellikleri]

Original Article

Clinical and Demographic Characteristics of 78 Patients with Adrenal Incidentaloma [Adrenal İnsidentalomalı 78 Hastanın Demografik ve Klinik Özellikleri]

Faruk Kilinc, Mazhar Muslum Tuna, Sezgin Barutcu, Zafer Pekkolay, Hikmet Soylu, Alpaslan Kemal Tuzcu

   

Abstract
Adrenal incidentalomas (AIs) are adrenal lesions detected on abdominal imaging procedures or abdominal laparotomy that had been performed for unrelated reasons. AIs have become a common clinical concern as a result of widespread use of abdominal ultrasound, CT and MR imaging in clinical practice. The aim of this study was to evaluate the demographical and clinical data our patients with AI. This study included data from 78 patients (53 female – 25 male) with AI those followed at Dicle University School of Medicine, Department of Endocrinology and Metabolism, between 2007 and 2013. Data collected from the records were physical and hormonal evaluation, diameter of the lesion, and the features of the lesion on radiological imaging. Also the results of serum cortisol, aldosterone, renin and 24 hour urinary metanephrine and normetanephrine were recorded. The average age of patients were 48.6 ±14.9 years. There was no significant difference in terms of localization of adenomas. Body mass ındex of patients were 28.54 ± 5.82. Of the patients, 45 (57.7%) were diagnosed as non-functional AI, 10 (12.8%) as subclinical Cushing’s syndrome, 11 (14,1%) as pheochromocytoma, 2(2.6%) as primary hyperaldosteronism, and 3(3.8%) as adrenal carcinoma. Ganglioneuroma was stated in 2 patients (2.6%), myelolipoma was stated in 1 patient (1.3%), adrenal adenoma was stated in 1 patient, adrenal cyst was stated in 1 patient, schwannoma was stated in 1 patient and neoplasia with small circular cells was stated in 1 patients. AIs are currently more frequently detected in clinical practice due to increased use of imaging techniques. Although the vast majority of AIs are benign and non-functioning, appropriate hormonal evaluation and imaging procedures must be performed.

Key words: Adrenal incidentaloma, demographic characteristics, epidemiology

Med-Science. 2015; 4(2): 2181-95