Menü Kapat

Efficacy and safety of combined vs. single renin-angiotensin-aldosterone system blockade in chronic kidney disease

Original Article

Efficacy and safety of combined vs. single renin-angiotensin-aldosterone system blockade in chronic kidney disease

Mona A. Abdelrahman, Ashraf Genina, Amira S. A. Said, Mohamed E. A. Abdelrahim

   

Abstract
Hypertension and proteinuria are well-known predictors of chronic kidney disease (CKD) progression. Therapeutic interventions have different magnitude of albuminuria and hypertension. This study was designed to evaluate the efficacy and safety of combined vs. single renin-angiotensin-aldosterone system (RAAS) blockade in chronic kidney disease. Forty (28 female) patients with chronic kidney diseases were collected from nephrology outpatient clinic, internal medicine department, Beni Suef University hospital. They were divided randomly into 2 groups. Group A was 24 (20 females) patients treated with Enalapril, as angiotensin converting enzyme inhibitor (ACE-I) alone. Group B was 16 (8 females) patients treated with combination of Enalapril and Irbesartan, as angiotensin receptor blocker (ARB). All patients were subjected to full history taking; thorough clinical examination; certain laboratory tests and renal function tests at the start of the study, 1.5 and 3 months later. Proteinuria, urinary albumin/creatinine ratio (UACR), systolic blood pressure (SBP) and glomerular filtration rate (GFR) were significantly (p

Key words: Renin-angiotensin-aldosterone system, proteinuria, chronic kidney disease (CKD), Angiotensin converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), dual therapy, renal failure, hypertension, diabetic nephropathy and dual RAAS blockade, combination

Med-Science. 2016; 5(3): 751-7

 
Medicine Science Vol:5 Issue:3 Year:2016 PP:751–918

Relationship between the abo blood group and hyperemesıs gravidarum, anemia, and preeclampsia

Original Article

Relationship between the abo blood group and hyperemesıs gravidarum, anemia, and preeclampsia

Maria Sonda, Ros Rahmawati, Husnah Husnah, Andi Zulfaidawati, Hidayati Hidayati

   

Abstract
This study aimed at analyzing the relation between ABO blood group with three pregnancy complications that frequently occur in Indonesia (hyperemesis gravidarum, anemia, and preeclampsia). The sample was all the pregnant women recorded in the medical record in RSKDIA Pertiwi Makassar, Makassar Baji Labuang Hospital and Health Center-Kassi Kassi Makassar in 2013. Inclusion criteria for this study included maternal age 20-35 years, gestational age of over 28 weeks, domiciled in Makassar City, signed the informed consent form to participate in this research. Exclusion criteria included a history of blood disorder disease. ABO blood group was assessed by standard procedures using agglutination technique. There is no significant association between ABO blood group and the incidence of hyperemesis gravidarum (p> 0.05). There is no significant association between ABO blood group and the Gestational anemia incidence (p> 0.05). There is significant association between ABO blood group and the preeclampsia incidence (p < 0.05). In conclusion, there is a relationship between ABO blood group and the incidence of preeclampsia in pregnant women. Therefore, pregnant women need to go through the blood group screening from the beginning of pregnancy.

Key words: pregnancy; complications; hyperemesis gravidarum; anemia; preeclampsia

Med-Science. 2016; 5(3): 758-60

 

Results of dexamethasone implant in macular edema of variable etiologies [Farklı etyolojilere bağlı maküla ödeminde intravitreal deksametazon implantasyonu sonuçları]

Original Article

Results of dexamethasone implant in macular edema of variable etiologies [Farklı etyolojilere bağlı maküla ödeminde intravitreal deksametazon implantasyonu sonuçları]

Taner Kar, Yavuz Cakir, Yildıray Yildirim, Ali Ayata

   

Abstract
Macular edema is the most important cause of vision loss at the disease such as diabetic retinopathy, retinal vein root or branch occlusion, age related macular degeneration and uveitis. In our study, the findings from 50 eyes of 46 patients with the implementation of one dose intravitreal dexamethasone (IVD) diagnosed of retinal vein root or branch occlusion, diabetic retinopathy and macular edema related to non-enfective posterior uveitis, followed up at least 6 months after injection were evaluated retrospectively.Patients were evaluated of best corrected visual acuity (BCVA) and central macular thickness (CMT) before injection and 7th day, 1th, 2nd, 3th and 6th months after injection.All patients mean CMT and BCVA outcomes were compared before injection with 7th day, 1th, 2nd, 3th and 6th months after injection and the results were statistically significant (p

Key words: Intravitreal dexamethasone implant, macular edema, BCVA, CMT

Med-Science. 2016; 5(3): 761-6

 

The success of extracorporeal shock wave lithotripsy at stones up to 10 mm in horseshoe kidneys

Original Article

The success of extracorporeal shock wave lithotripsy at stones up to 10 mm in horseshoe kidneys

Muhammet Guzelsoy, Soner Coban, Ali Riza Turkoglu, Sedat Oner, Ahmet Cumhur Kose, Murat Demirbas

   

Abstract
Aim of this study is to research retrospectively the effectiveness of extracorporeal shock wave lithotripsy (SWL) for horseshoe kidney according to the size of stones. SWL treatment applied on 27 kidney stones in 21 patients at a single center were examined retrospectively. Stones were classified according to their size, the number of shock waves applied and average session number. The mean age of the patients was 44 (18-70). Stone sizes were 16mm (7-40) X 10mm (5-30). Average of sessions was 2.55 (1-3) and shock number was 1643 (977- 2300). The success rate of SWL treatment at horseshoe kidney stones which were under 10 mm was 90% and for over 10 mm it was 30% (p=0.001). Success rates were detected 63%, 52% and 48%; respectively up to 0-15 mm, 0-20mm and for all stones. The SWL success rate with horseshoe kidney is similar to that in normal kidney. The success rate decreases as stone size increases. SWL is a safe and effective treatment option for horseshoe kidney stones. Especially for stones up to 10 mm, the rate of SWL’s success rate is pretty high.

Key words: Effectiveness of SWL, horseshoe kidney, stone, 10 mm

Med-Science. 2016; 5(3): 767-70

 

Evaluation of renal tubular function in epileptic children treated with levetiracetam

Original Article

Evaluation of renal tubular function in epileptic children treated with levetiracetam

Ahmet Taner Elmas, Serdal Gungor, Mujgan Arslan, Yilmaz Tabel, Sabiha Gungör Raif, Fatma Ozyalin

   

Abstract
Our study aim was to measure the urinary N-acetyl-β-D-glucosaminidase/creatinine (NAG/UCr) index in epileptic children who received levetiracetam (LEV) treatment at least for 6 months, and compare it to healthy children. Thirty five children with epilepsy were enrolled in this prospective study. NAG was studied using the calorimetric method and NAG levels were expressed in units per liter (U/L) and NAG/UCre levels were determined in U/mmol creatinine. There were no statistically significant differences for the urine NAG and NAG/UCr index before and after LEV treatment in the epileptic group (p>0.05, for each). There were no significant correlations between the serum concentration of LEV and urinary NAG levels (r=0.258, p=0.135) and NAG/UCr levels (r=0.164, p=0.346) before treatment. Our study demonstrated that LEV treatment was safe and did not interfere in renal tubular function in epileptic children.

Key words: Children, epilepsy, levetiracetam, N-acetyl-β-D-glucosaminidase, renal tubular function

Med-Science. 2016; 5(3): 771-5

 

Predictive role of transvaginal ultrasonographic measurement of cervical length at 22-26 weeks of gestation for preterm deliveries in twin pregnancies

Original Article

Predictive role of transvaginal ultrasonographic measurement of cervical length at 22-26 weeks of gestation for preterm deliveries in twin pregnancies

Turkan Dikici Aktas, Mehmet Cinar, Selen Yaman, Sevgi Ayhan, Nuri Danisman

   

Abstract
Previous studies in overweight men have shown an increased likelihood of abnormal semen parameters. Obesity has been found to be associated with male subfertility. In this study we aimed to investigate the effect of obesity on semen parameters and hormone levels in infertile males.This was a prospective cross-sectional study designed to assess the influence of obesity on semen parameters and hormone levels in infertile men. 88 obese [Body mass index (BMI) ≥30 kg/m2] men and 169 non-obese (BMI

Key words: Twin pregnancies, cervical length, preterm delivery

Med-Science. 2016; 5(3): 776-9

 

The impact of obesity on semen parameters and hormone levels in infertile men

Original Article

The impact of obesity on semen parameters and hormone levels in infertile men

Erkan Ozdemir, Aytekin Tokmak, Ahmet Deniz Tuzluoglu, Sezen Bozkurt Koseoglu, Mehmet Cinar, Ayse Sahin, Nafiye Yilmaz

   

Abstract
Previous studies in overweight men have shown an increased likelihood of abnormal semen parameters. Obesity has been found to be associated with male subfertility. In this study we aimed to investigate the effect of obesity on semen parameters and hormone levels in infertile males. This was a prospective cross-sectional study designed to assess the influence of obesity on semen parameters and hormone levels in infertile men. 88 obese [Body mass index (BMI) ≥30 kg/m2] men and 169 non-obese (BMI

Key words: Body mass index, male infertility, obesity, sperm parameters, testosteron/estradiol ratio

Med-Science. 2016; 5(3): 780-4

 

Circulating ADAMTS-12 levels in early- and late-onset severe preeclampsia

Original Article

Circulating ADAMTS-12 levels in early- and late-onset severe preeclampsia

Ayse Kirbas, Korkut Daglar, Hakan Timur, Zehra Yilmaz, Gulenay Gencosmanoglu, Nuri Danisman

   

Abstract
Aim of this study is to determine whether maternal serum ADAMTS-12 levels differ among early-onset (

Key words: Preeclampsia, ADAMTS-12, placenta, trophoblast, matrix metalloproteinase

Med-Science. 2016; 5(3): 785-9

Parameters affecting to select of contraceptive methods

Original Article

Parameters affecting to select of contraceptive methods

Mehmet Cinar, Hakan Timur, Rifat Taner Aksoy, Demet Kokanali, Aytekin Tokmak, Yasemin Tasci

   

Abstract
Aim of this study is to evaluate the relationship between choose a contraceptive method and demographic values in patients who examined in our family planning clinic. This study included 252 patients who want to choose a contraceptive method to prevent pregnancy in Zekai Tahir Burak Women Health and Resource Hospital family planning clinic. Risk factors recorded were age, gravidity, parity, duration of marriage, education status, systemic disease and selected contraceptive method. The mean age of the study group was 30.4±8.6 and the mean of the duration of marriage, gravidity, parity were 9.4±6.2(0-12) years, 3.1±1.6 (0-7), 2.6±1.4 (0-5); respectively. The most commonly used method were coitus interruptus (% 30.6). The frequency of other methods were; intrauterine device (IUD) (%29.7),oral contraceptives (%15.1), condom (%11.5), tubal ligation (% 3.1), depot progesterone (%9.12), subcutaneous implants (%0.8); respectively. Women’s level of education increases, subcutaneous implants , oral contraceptives and IUD use was increasing (p

Key words: Contraception, contraceptive methods, education level

Med-Science. 2016; 5(3): 790-2

How will amendments in crimes agaınst sexual privacy and failure to evaluate the mental health of the victims will affect them? [Cinsel dokunulmazlığa karşı suçlarda yapılan kanun değişikliği ile ruh sağlığının değerlendirilmemesinin mağdurlara etkisi ne olacak?]

Original Article

How will amendments in crimes agaınst sexual privacy and failure to evaluate the mental health of the victims will affect them? [Cinsel dokunulmazlığa karşı suçlarda yapılan kanun değişikliği ile ruh sağlığının değerlendirilmemesinin mağdurlara etkisi ne olacak?]

Mustafa Talip Sener, Sadik Sahingoz, Ibrahim Selcuk Esin, Halil Ozcan, Ahmet Nezih Kok

   

Abstract
The concepts of physical or mental health were removed from the articles regulating the crimes against sexual immunity in the Turkish Penal Code. Today, judicial authorities don’t require forensic medical evaluation of physical or mental health of the victims. In this study, it is aimed to investigate the effect of the amendment on psychiatric examinations in the forensic medical examination of victims of sexual crimes. The data of 292 cases, who were evaluated by a committee established in accordance with 7th, 23rd and 31st Articles of Institute of Forensic Medicine Act between January 1, 2012 and July 30, 2015 at Atatürk University Faculty of Medicine to see if there is any negativities in the physical or mental health of the victims, were reviewed retrospectively. In these evaluations, psychopathology was identified in 58.6% (n=171) of the cases due to sexual trauma. Before the evaluation of the committee, the judicial authorities asked for both physical and mental results of sexual trauma of 62.6% (n=183) of the cases and psychiatric results of sexual trauma of 37.4% (n=109) of the cases as part of the forensic medical assessment. The psychiatric examination of these 109 cases was done by this committee for the first time and psychopathology was identified in 56.9% (n=62) of these cases due to sexual trauma. Psychiatric examination of victims of sexual crimes is a medical obligation independent from the legal process. Although the law changes, forensic medical examination of the victims should be done to include psychiatric examinations with a multidisciplinary approach.

Key words: Sexual crime, psychiatric examination, major depressive disorder, post-traumatic stress disorder

Med-Science. 2016; 5(3): 793-6