Menü Kapat

Comparison of liquid based cytology results with conventional cytology results in screening cervical cancer

Original Article

Comparison of liquid based cytology results with conventional cytology results in screening cervical cancer

Nezaket Kadioglu, Sibel Ozler, Eda Gulmez, Basak Gumus, Ebru Aslan Patlakoglu

   

Abstract
Our objective is to compare and evaluate the liquid based cytology (LBC) results with the conventional cytology (CC) results for cervical cancer. Cross sectional study. The results of 1531 women, applied to our outpatient clinic, for cervical cancer screening between the years 2012- 2015, were evaluated. We have applied liquid based cytology on 958 (62.6%) of the patients, and conventional cytology on 573 (37.4%) of the patients. Unsatisfactory smear results for examination were found to be significantly lower in LBC compared to CC (20.3% vs. 0.4%, p

Key words: Liquid based cytology, conventional cytology, cervical cancer screening, smear test

Med-Science. 2016; 5(4): 919-27

 
Medicine Science Vol:5 Issue:4 Year:2016 PP:919-1084

Outcomes of radiotherapy in early stage glottic laryngeal carcinoma: a single center experience

Original Article

Outcomes of radiotherapy in early stage glottic laryngeal carcinoma: a single center experience

Kemal Ekici, Oztun Temelli, Ayse Fatma Eraslan, Simay Gurocak, Nihal Kaplan Bozdag, Emin Tamer Elkiran, Ersoy Kekilli, Ahmet Kizilay

   

Abstract
Our aim was to determine the treatment outcomes and the prognostic factors affecting local control in early stage glottic carcinoma (ESGC) treated with definitive radiotherapy (RT). Between April 2003 and May 2015, 76 patients with ESGC were treated at Inonu University Hospital. There were 58 patients with T1a, 7 T1b and 11 with T2 tumors. Twenty-two patients were treated with conformal radiotherapy, 31 patients were treated with conventional RT and 23 patients were treated with intensity modulated radiotherapy as initial treatment. During a median follow-up of 51 months (range 6-136), 11 patients had failures. Five year overall survival rates were 73.7% in T1 and 81.8% T2. Local control rate was 85.5% in our patients. Patients who were over 61 years had significantly lower local control (p = 0.042). One patient treatment was interrupted because of grade 3 edema. One patient had grade 3 dermatitis, 2 patients grade 3 mucositis and 4 patients grade 3 edema, respectively. Our results suggest that curative radiotherapy is an effective treatment modality in ESGC without increasing toxicity. Age proved to be the only independent prognostic factor affecting local control after primary radiotherapy according to the results of this study.

Key words: Glottic cancer, radiotherapy, treatment, side effect

Med-Science. 2016; 5(4): 928-32

 

Is neck dissection necessary in early stage lower lip carcinomas necessary?

Original Article

Is neck dissection necessary in early stage lower lip carcinomas necessary?

Orhan Kemal Kahveci, Cigdem Tokyol, Yavuz Demir, Erdogan Okur, Selcuk Kuzu, Abdullah Aycicek, Nurten Haktanir

   

Abstract
Lower lip tumours are the most common among the oral cavity tumours. The purpose of this article is to analyse neck metastasis rates of early stage lower lip carcinomas and to evaluate possible related histological parameters with neck metastasis. The dissection types, preoperative detection of lymphadenopathy by palpation or computed tomography (CT), tumour sizes and tumour histological differentiation degrees of 37 patients were reviewed retrospectively. In addition, an experienced pathologist re-evaluated the specimens and examined tumour depth and muscle invasion. Types of neck dissection were bilateral supraomohyoid in 20, unilateral supraomohyoid in 8, bilateral suprahyoid in 5 and unilateral suprahyoid in 1 patients. All the carcinomas were squamous cell carcinoma (SCC) and T stages were T1 in 32 and T2 in 5. Preoperatively, 4 patients had palpable lymph nodes and 9 patients had lymph nodes in CT scan, but it was found out that none of these patients had histological positive lymph node metastasis. Histological node metastasis was found only in 1 patient who had stage T1 tumour, no palpable or detected lymph node, no muscular invasion and very limited tumour depth.Tumour size, differentiation degree, tumour depth and muscle invasion seems insensitive for predicting lymph node metastasis in early stage lower lip carcinomas. The necessity of neck dissection in early stage lower lip carcinomas should be reconsidered in large series of patients.

Key words: Lower lip carcinoma, neck dissection, squamous carcinoma, lymph node metastasis

Med-Science. 2016; 5(4): 933-6

 

Characteristics of recurrent emergency department visits within 72 hours of visits for the same or related complaints

Original Article

Characteristics of recurrent emergency department visits within 72 hours of visits for the same or related complaints


Sercan Bicakci, Nurcan Bicakci, Ali Duman, Ridvan Atilla

   

Abstract
We aimed to investigate the characteristics of recurrent emergency department visits within 72 hours for the same or related complaints. Recurrent visits were defined as any repeated visits to the emergency department within the first 72 hours of discharge after the first admission with the same or similar complaints. The study population included patients revisiting the emergency department within 72 hours after the first visit. Recurrent visit files were screened from the Hospital Information Management System, and data were compared between the first and second visits. Of the 83,578 patients included, 1,952 (2.3%) fulfilled the inclusion criteria. Thus, the revisit rate was 2.3%. Emergency Department triage scores showed no significant differences between the visits, but 2 patients with triage scores of 4 in the first visit subsequently had triage score of 1 in the recurrent visits. In addition, the presence of comorbidities was found to be significantly associated with revisit and hospitalization. Measuring and evaluating the causes of revisits to the emergency department allow assessment of hospital quality. We believe that to reduce the revisit rate, prolonged emergency room observation is necessary, particularly for patients with comorbidities and those presenting complaints related to the cardiovascular system, oncology, and respiratory system. Further, morbidity and mortality rates will consequently decrease.

Key words: Emergency department, revisit, mortality, morbidit

Med-Science. 2016; 5(4): 937-40

 

Risk factors of placenta previa: a population based study and the review of the literature

Original Article

Risk factors of placenta previa: a population based study and the review of the literature

Cetin Aydin, Serenat Eris Yalcin, Yakup Yalcin, Dilek Uysal, Mehmet Ozgur Akkurt, And Yavuz, Halime Sen Selim, Esra Nur Tola

   

Abstract
The aim of our study is to provide a population-based risk factor profile for placenta previa and thereby enable early diagnosis plus the necessary management for this risky group. Methods This research was a retrospective case control study including 25105 pregnancies in the period January 2000- December 2010. The data of 25105 pregnancies were examined on the hospital database. A total of 139 single pregnancies complicated by placenta previa were compared with a randomly selected control group of 1200 single pregnancies. Evaluation was made of risk factors for placenta previa. Results Of the 25105 pregnancies presenting at our clinic during the 10-year period, placenta previa was determined in 139, giving an incidence rate of 0.55%. In the comparison of the two groups; advanced maternal age, multiparity, a history of caesarean section, a history of abortion or uterine curettage, cigarette smoking and male gender were found to be statistically significant as a risk factor for placenta previa. Conclusions The knowledge of the predisposing obstetric factors in respect of the development of placenta previa on a population basis provides the possibility of a careful approach on an individual patient basis.

Key words: Antepartum bleeding, placental pathology, placenta previa, risk factors

Med-Science. 2016; 5(4): 941-4

 

Electrocardiographic changes in young smokers: a cross-sectional study

Original Article

Electrocardiographic changes in young smokers: a cross-sectional study

Renu Yadav, Subodh Kumar Yadav, Abhishek Karn

   

Abstract
This article assesses few electrocardiographic parameters in young adults (students) caused by smoking. The electrocardiogram of young smokers (with a history of at least six months of smoking) and young non-smokers were recorded using 12 leads, three channel ECG machine and the data thus obtained were analyzed statistically. It was found that there is extremely statistically significant difference in the timings of P-R interval and T-P interval when young smokers were compared with young non-smokers.

Key words: Electrocardiography, PR interval, TP interval, QRS complex

Med-Science. 2016; 5(4): 945-7

 

Combined percutaneous ethanol injection and mitoxantrone versus radiofrequency ablation in the treatment of hepatocellular carcinoma

Original Article

Combined percutaneous ethanol injection and mitoxantrone versus radiofrequency ablation in the treatment of hepatocellular carcinoma

Besher Helmy, Sami Abdel-Wahab, Mostafa El-Shamy, Sameh M Abdel Monem, Hosam M Dawod

   

Abstract
New therapeutic choices have been developed for hepatocellular carcinoma, including percutaneous ablation therapy, transarterial chemoembolization, radiation therapy and molecular target therapy. Ablation of liver tumors is currently the main alternative to liver resection. This work aimed at comparing percutaneous combined local injection of ethanol and mitoxantrone versus percutaneous radiofrequency ablation in the treatment of Hepatocellular Carcinoma. This study included 124 patients with hepatocellular carcinoma, they were randomly divided into two groups; group I (64 patients) treated with local injection of ethanol plus mitoxantrone. Group II (60 patients) treated with radiofrequency ablation. Clinical assessment, laboratory evaluation and CT studies were performed to all patients prior to treatment and at 1, 3, 6, and 12 months’ post treatment. The percentage of ablation in both groups at 1, 3, 6 and 12 months were 81.3%, 81.3%,76.6 and 71.9% in group I respectively versus 88.3%, 88.3, 85%% and 81.7% in group II respectively with no statistical significant difference between the two groups. Percentage of ablation in small tumors is higher than large tumors in both groups. Side effects and complications are statistically higher in group II than group I. Combination of percutaneous local injection of ethanol and mitoxantrone is comparable to radiofrequency ablation with less frequent complications in the treatment of Hepatocellular Carcinoma when surgical resection or liver transplantation is not amenable or available.

Key words: Hepatocellular carcinoma, mitoxantrone, radiofrequency

Med-Science. 2016; 5(4): 948-56

 

Maternal and perinatal effects of vaginal delivery after caesarean section

Original Article

Maternal and perinatal effects of vaginal delivery after caesarean section

Sibel Ozler, Efser Oztas, Basak Gumus Guler, Aykan Yucel, Dilek Uygur

   

Abstract
We aimed to determine the risk factors of vaginal delivery after caesarean section (VDAC) that may be effective on maternal and neonatal outcomes and compare the pregnancy outcomes of VDAC with the results of the previous caesarean delivery. 36 women, who had VDAC in Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital between 2009-2014 years, were included in this study. Mean age of patients was 32.53± 3.595, mean birth week of previous caesarean was 38.21 ± 1.84 and mean birth week of present vaginal delivery was 36,10 ± 3,99. Birth weeks of previous caesarean and present vaginal deliveries were significantly different. Neonatal birth weight was not significantly different between these groups. Gravida and parity of the patient, and the number of previous vaginal deliveries, have been identified as factors that reduce adverse pregnancy outcomes by lineer regression analysis. Increased number of previous vaginal deliveries, gravida and parity reduce the adverse pregnancy outcomes in women having VDAC.

Key words: Vaginal delivery after cesarean, caesarean, maternal and perinatal complications

Med-Science. 2016; 5(4): 957-60

 

Predictivity of stimulated serum thyroglobulin and antithyroglobulin antibodies for the efficacy of thyroid remnant ablation on patients with differentiated thyroid carcinoma

Original Article

Predictivity of stimulated serum thyroglobulin and antithyroglobulin antibodies for the efficacy of thyroid remnant ablation on patients with differentiated thyroid carcinoma

Narin Nasiroglu Imga, Serhat Isık, Mehtap Navdar Basaran, Bercem Aycicek Dogan, Mazhar Muslum Tuna, Mustafa Unal, Dilek Berker, Serdar Guler

   

Abstract
Differentiated thyroid cancers (DTC) are the most frequently occuring endocrine malignancies and accounts for ≥ 90% of all thyroid cancers. It was suggested that after total or near total thyroidectomy, the stimulated thyroglobuline (sTg) and quantified uptake in whole body scintigraphy (WBS) are significant predictors for the successful ablation and disease-free status. We aimed to evaluate preablative thyroid stimulating hormone (TSH), sTg and anti-thyroglobulin antibodies (TgAbs) levels, after following thyroid hormone withdrawal, and compare them with diagnostic WBS (DxWBS) uptake for predict the efficacy of radioiodine (RAI) ablation therapy in DTC patients. We retrospectively investigated 100 consecutively patients which followed up for DTC in Ankara Numune Education and Research Hospital at Department of Endocrinology and Metabolism between January 2006 and June 2013. Patients had histologically confirmed DTC and underwent RAI remnant ablation therapy without clinical or radiological evidence of distant metastases. 131I was used generally from 30-200 mCi dosage in all 100 patients. (median dose, 100 mCi). Preablation TSH, preablation sTg, postablation TSH, postablation sTg, postablation TgAbs levels, tumor size and tumor multifocality did not differ between DxWBS uptake negative and positive groups, while the preablation TgAbs level was found significantly lower in DxWBS uptake negative group (p

Key words: Differentiated thyroid cancers, anti-thyroglobulin antibodies, 131I whole body scintigraphy

Med-Science. 2016; 5(4): 961-6

 

The relaxant responses induced by ethanol in the smooth muscle: role of extracellular and intracellular Ca2+ [Düz kasta etanol ile indüklenen gevşeme cevapları: ekstraselüler ve intraselüler Ca2+’un rolü]

Original Article

The relaxant responses induced by ethanol in the smooth muscle: role of extracellular and intracellular Ca2+ [Düz kasta etanol ile indüklenen gevşeme cevapları: ekstraselüler ve intraselüler Ca2+’un rolü]

Derya Kaya, Naciye Yaktubay Dondas

   

Abstract
Since worldwide alcohol consumption, the understanding the mechanism of action of ethanol is important in the gastrointestinal tract. In this study we aimed to clarify the role of extracellular and intracellular calcium (Ca2+) on relaxations induced by ethanol in isolated mouse gastric fundus. Mice (Swiss albino) of either sex were used in this study. After killing the mice by cervical dislocation the gastric fundal strips were prepared by longitudinal incision and mounted under 0.5 g tension in an organ bath filled with Tyrode’s solution. The bath medium was maintained at 37 oC and gassed with %95O2 and 5%CO2. Experimental data were recorded by an isometric transducer. Ethanol (164 mM) caused reproducible relaxations in isolated mouse gastric fundal strips. These relaxations were significantly inhibited by verapamil (10-5-5×10-4 M), a blocker of L-type Ca2+ channels, and ruthenium red (10-5-10-4 M), a blocker of ryanodine receptors (intracellular Ca2+ channels) in a concentration dependent manner. On the other hand cyclopiasonic acid (CPA; 10-6-10-5 M), a blocker of Ca2+-ATPase, failed to affect the relaxations induced by ethanol. The results of experimental data suggest that extracellular Ca2+ influx and intracellular Ca2+ release may play a role on relaxations induced by ethanol in the isolated mouse gastric fundal smooth muscle.

Key words: Ethanol, relaxation, Ca2+, gastric fundus

Med-Science. 2016; 5(4): 967-71