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When and how should leeches be applied in cases of venous congestion?

Original Artcile

When and how should leeches be applied in cases of venous congestion?

Cengiz Aldemir, Fatih Duygun

   

Abstract
Aim of this study is to discuss the results of cases where leeches were applied to prevent the development of venous congestion following replantation and flap surgery. Methods Leeches were applied to a total of 31 patients with appropriate and sufficient follow-up in the Orthopaedics and Traumatology Clinics of Antalya State Hospital and Antalya Training and Research Hospital between 1997 and 2015. The patients comprised 20 cases of replantation and 11 cases of crush syndrome. The rates of necrosis were examined in these patients following the application of leeches. Results Following the application of leeches, necrosis was determined in 5 of the 20 adult replantation or revascularisation cases with venous congestion and in 6 of the 11 cases of crush injury. No serious allergic reaction was observed in any case following leech application. Conclusion In patients with replantation or crush injuries who cannot be treated by conventional methods, the application of leeches is an effective method in the treatment of venous congestion.

Key words: Replantation, crush, leeches, venous congestion

Med-Science. 2017; 6(1): 1-4

 
Medicine Science Vol:6 Issue:1 Year:2017 PP:1-181

The effects of ankaferd blood stopper on DNA damage and enzymes with paranchymal damaged rabbits

Original Artcile

The effects of ankaferd blood stopper on DNA damage and enzymes with paranchymal damaged rabbits

Bayram Metin, Esma Menevse, Abdullah Sivrikaya, Tamer Altinoks, Hilal Arikoglu

   

Abstract
Ankaferd blood stopper (ABS) is a medical product that is used in several injuries, dental operations, prevention of minor or major bleeding after spontaneous or surgerical operations and have anti-microbial, anti-inflamatory, anti-thrombin, anti-platelet, anti-atherosclerotic, anti-oxidants effects. The present study is aimed to evaluate the effects of ABS on 8-hydroxy-2ˈ-deoxyguanosine (8-OHdG), superoxide dismutase (SOD), myeloperoxidase (MPO) levels over pleural adhesions in rabbits with pulmonary parenchymal damage.16 New Zelland species rabbits were divided in two groups such as control (n=7) and study group (n=7). One rabbit in each group died during anesthesia. In both groups, we performed wedge resections in equal size to the left lower lobes of all rabbits. No interventions were made on control group, whereas 5 puff’s (1 cc) ABS was performed to the resection area at study group. Tube thoracostomy that performed both groups were terminated postoperatively at 6th hour after drainage and air leakages follow up. Rabbits were sacrificed with anesthetics at postoperative 8th day. Lung tissues were collected for analyzing of 8-OHdG, SOD, MPO. The 8-OHdG levels were respectively 2.01±0.39 ng/ml in control group and, 0.38±0.12 ng/ml in study. The differences between study and control group were statistically important group (p

Key words: Ankaferd, paranchyme damage, 8-hydroxy-2ˈ-deoxyguanosin, superoxide dismutase, myeloperoxidase

Med-Science. 2017; 6(1): 5-10

 

Evaluation of the early results of ab interno trabeculectomy surgery appllied with trabectome device

Original Artcile

Evaluation of the early results of ab interno trabeculectomy surgery appllied with trabectome device

Eyup Duzgun, Yildiray Yildirim, Akin Cakir, Melih Hamdi Unal, Ali Ayata, Murat Sonmez

   

Abstract
The aim of the current study was to assess efficacy and safety of ab interno trabeculectomy surgery applied with trabectome device in early period. The study was designed among the 30 eyes of 26 patients who had undergone trabectome surgery with the diagnosis of open-angle glaucoma. Patients were evaluated as retrospectively in terms of preoperative and postoperative intraocular pressure (IOP), number of drugs used and complications. While the preoperative mean IOP was 28.78±5.57 mmHg (n:30) with the mean number of medications 3.40±1.04, the mean IOP was 18.24±5.54 mmHg (n:30) with the mean number of medications 0.90±1.27 at 1st month. At 3rd month the mean IOP was 16.37±3.36 mmHg (n:28) with the mean number of medications 0.70±1.10 and at 6th month the mean IOP was 16.51±3.80 mmHg (n:28) with the mean number of medications 1.13±0.96. When postoperative measurements compared with preoperative values, detected reductions in IOP and number of medications were statistically significant (P

Key words: Trabectome surgery, open angle glaucoma, minimally invasive glaucoma surgery

Med-Science. 2017; 6(1): 11-6

 

The study of blood smear as the analysis of images of various objects

Original Artcile

The study of blood smear as the analysis of images of various objects

Vyacheslav V Lyashenko, Asaad MA.Babker, Valentin A Lyubchenko

   

Abstract
Processing of microscope images in medicine is one of the priority research areas. Among the many medical imaging follows allocate the image of blood preparations. This is due to the fact that study of the image of blood preparations allows to conduct a comprehensive diagnosis of human health state. However, the specific complexity of visualization process of blood preparations and their subsequent processing with the use of automated processing determine the necessity to study different possibilities to use any approaches for image processing. We consider the image of blood preparations is a complex image. For image analysis of blood preparations’ structure, we use the method of color segmentation. For image analysis, we also use the methodology of the human-machine. This allows you to clarify the structure of the image of blood preparations. We give some of examples that show the effectiveness of the proposed image processing of blood preparations.

Key words: Erythrocytes, segmentation, blood plasma, blood cell, white blood cells, microscope image analysis

Med-Science. 2017; 6(1): 17-21

 

Comparison of ultrasonic pachymetry, with a new optical biometry and tono-pachymetry

Original Artcile

Comparison of ultrasonic pachymetry, with a new optical biometry and tono-pachymetry

Haci Murat Sagdik, Serdar Aktaş, Mehmet Tetikoglu, Fatih Ozcura

   

Abstract
The aim of this study was to compare the measurements of central corneal thickness (CCT) using the CT-1P tonopachymetry and AL-Scan optical biometry with those obtained with ultrasound (US) pachymetry. In this prospective study, CCTs were measured in 100 eyes of healthy subjects with the CT-1P tonopachymetry, AL-Scan optical biometry and US pachymetry, and the results were compared. The mean CCT taken with the CT-1P, AL-Scan optical biometry and US pachymetry were 514.1±34.96 µm, 540.00±29.57 µm and 542.53±31.2 µm, respectively. There were high correlations between CCT readings using US pachymetry and AL-Scan optical biometry (r=0.949, p= 0.001), between US pachymetry and CT-1P tonopachymetry (r=0.851, p< 0.001) and between AL-Scan optical biometry and CT-1P tonopachymetry (r=0.859, p< 0.001). Both AL-Scan optical biometry and CT-1P tonopachymetry are quick, non-contact devices that are easy to use and are reliable alternatives to US pachymetry for measuring CCTs.

Key words: Cornea, Pachymetry , Corneal central thickness

Med-Science. 2017; 6(1): 22-5

 

Comparison of minimal inhibitory concentrations (MICs) of tigecycline in 2011 and 2015 years against multidrug-resistance acinetobacter baumannii strains

Original Artcile

Comparison of minimal inhibitory concentrations (MICs) of tigecycline in 2011 and 2015 years against multidrug-resistance acinetobacter baumannii strains

Yucel Duman, Cigdem Kuzucu, Mehmet Sait Tekerekoglu

   

Abstract
Acinetobacter baumannii is an opportunistic pathogen that causing nosocomial infections. The microorganisms can be developed resistance to antimicrobials very quickly by different mechanisms. Infections defend by MDR strains, caused require long-term hospitalization high morbidity and mortality. Tigecycline is one of the few antimicrobials which have activity against MDR A. baumannii strains. In Meta-analyzes and clinical study reported that a rising risk of mortality in tigecycline-treated patients due to an increase in resistance of these strains. In our study, we aimed to compare the MICs values of tigecycline and determine the resistance rates of tigecycline against to MDR A. baumannii strains in 2011 and 2015. Tigecycline MIC values of 200 A. baumannii isolates were determined by the broth microdilution method. Final concentrations were prepared as 16μg/ml to 0.06μg/ml. Tigecycline MICs breakpoint values comments on breakpoint values of Enterobacteriaceae that have been proposed by FDA. In 2011, tigecycline values of MIC50 and MIC 90 found 0.5μg/ml, 1μg/ml, respectively against to MDR A. baumannii strains. In 2015, tigecycline values of MIC50 and MIC90 found 1μg/ml, 4μg/ml, respectively. In 2011 the 4%, while in 2015, 16% of A. baumannii strains’ tigecycline MICs were determined over 2μg/ml. and that this was interpreted as the resistance. Tigecycline can be still use as an alternative antimicrobial for treatment of A. baumannii strains, especially in our hospitals’ intensive care units. However, to avoid the development of resistance against tigecycline, we should prevent the irrational use of antibiotics. The implementation of treatment should be based on antimicrobial susceptibility test results.

Key words: Acinetobacter baumannii, tigecycline, resistance

Med-Science. 2017; 6(1): 26-9

 

The incidence of demodex in the Faculty of Science Students and measurement of these Students’ knowledge level about demodex.

Original Artcile

The incidence of demodex in the Faculty of Science Students and measurement of these Students' knowledge level about demodex.

Serpil Sener, Ulku Karaman, Gulden Hakverdi

   

Abstract
This study was purposed to unveil prevalence of Demodex in faculty of science students and to measure the level of knowledge about Demodex. The study population consisted of Ordu University Faculty of Science students. Participants were selected by random sampling method. A questionnaire including socio-demographic questions was applied. Standard superficial skin biopsy method was employed. In the study, after student volunteers filled out and signed Patients Informed Form, standardized surface skin biopsy from the face after signed (SYDB) samples were taken and analyzed. In the study, 34 (22.7%) of the subjects were males, 116 (77.3%) were females. The mean age of subjects with the standard deviation was 20.10 ± 2.11. 69 (46%) students were found as Demodex spp. All of the students were 1^st,2^nd,3^(rd )and 4^th year Science Faculty students. The study demonstrated that Demodex spp. is a widespread health problem in the faculty of Science students, but the level of knowledge about the Demodex spp. isn’t high enough.

Key words: Demodex, surface skin biopsy, prevalence

Med-Science. 2017; 6(1): 30-4

 

 

The effect of licorice drink on cytochrome P3A6 and P-glycoprotein gene transcription in rabbits

Original Artcile

The effect of licorice drink on cytochrome P3A6 and P-glycoprotein gene transcription in rabbits

Rawia Al-Balawnih, Suheil Zmeili, Yacoub Irshaid, Malek Zihlef

   

Abstract
The effect of licorice drink, a widely used herb in the Middle East, on hepatic and intestinal cytochrome P3A6 (CYP3A6) and P-glycoprotein (P-gp) gene transcription using rabbit as an animal model was assessed. This article reports that licorice treated groups showed a significant induction of hepatic CYP3A6 expression by 17.6-folds, and an inhibition of intestinal CYP3A6 expression by 7.6-folds. Licorice administration did not affect P-gp expression neither in hepatic nor in intestinal tissues. It is concluded that licorice can affect the metabolism of drugs that are CYP3A6 substrates, but it might not affect the transport of drugs dependent on P-gp.

Key words: Licorice, CYP3A4, CYP3A6, P-gp, rifampicin, transcription

Med-Science. 2017; 6(1): 35-40

 

General anesthesia management in carotid endarterectomy surgery: a single center experience

Original Artcile

General anesthesia management in carotid endarterectomy surgery: a single center experience

Ahmet Selim Ozkan, Sedat Akbas, Mehmet Akif Dural, Osman Kacmaz, Mehmet Ozcan Ersoy, Mahmut Durmus

   

Abstract
Carotid endarterectomy (CEA) is an effective surgery which is applied in order to reduce the risk of stroke associated with severe stenosis of the carotid artery. Anesthesia management is important in these patients due to high incidence of cardiovascular disease and studies are in progress for ideal anesthesia management. In this study, we aimed to share our experience in carotis endarterectomy and evaluate the clinical outcomes and review retrospectively.
Patients informations were obtained from the patients and anesthesia records. Age, ASA physical status, Mallampati score (MP), anesthesia and surgery duration, ICU and discharge time, blood transfusion rate, anesthetic and analgesic drugs, invasive procedures, complications, smoking, stenosis side and ratio, comorbid conditions of patients and drugs were recorded. The mean age of patients was 67.19±1.07 (33-98). It was evaluated that 44 patients (61.2%) were ASA II, 28 patients (38.8%) were ASA III. It was recorded that mean duration of anesthesia was 226.25 ± 37.99 min, duration of surgery was 195.83±38 min, ICU stay was 2.45 ± 2.52 days and hospital stay time was 5.23 ± 2.77 days. 29 of patients (40.3%) were smokers and 7 of patients (9.7%) were identified as secondary smokers. The mortality rate was 6.9% (5 patients). Clinical experience and outcome data from our study are consistent with the literature. In CEA surgery, anesthetic technique that is safe enough to guide the evidence is not there yet. Experience of the anesthesiologist and the surgeon as surgical anesthetic management of CEA is an important point to be noted that the current developments in the patient’s characteristics and monitoring.

Key words: Carotid endarterectomy, general anesthesia, vascular surgery, anesthesia management

Med-Science. 2017; 6(1): 41-5

 

Effect of lead nanoparticles inhalation on bone calcium sensing receptor, hydroxyapatite crystal, and receptor activator of nuclear factor-kappa B in rats

Original Artcile

Effect of lead nanoparticles inhalation on bone calcium sensing receptor, hydroxyapatite crystal, and receptor activator of nuclear factor-kappa B in rats

Rendra Leonas, Zairin Noor, Hermawan Nagar Rasyid, Tita Husnitawati Madjid, Fachry Ambia Tanjung

   

Abstract
This study aimed to investigate whether Pb nanoparticle exposure affects the bone calcium sensing receptor (CaSR), hydroxyapatite crystal, and receptor activator of nuclear factor-kappa B (RANK) in rats exposed to subchronic and chronic inhalation. Thirty two rats were randomly divided into eight groups. One group is a non-exposed group. While three groups were exposed to nanoparticles Pb at the following doses 6.25; 12.5; or 25 mg/m3 an hour daily for 28 days. Another three groups were exposed to nanoparticles Pb at following doses 6.25; 12.5; and 25 mg/m3 one hour daily for 6 months. The expression of trabecular CaSR was significantly decreased at the all doses subchronic exposure compared to the control group (P < 0.05). The CaSR expression significantly decreased in second and third doses subchronic exposure groups compared to the control groups (P < 0.05). With subchronic exposure, the crystal size was increased in second dose group and decreased in lowest and highest doses compared to the control (untreated) group. The crystal size and c-axis were decreased in all dose chronic exposures compared to the control (untreated) group. The expression of cortical RANK was significantly lower at the two lowest dose chronic exposures compared to the control group (P < 0.05). In conclusion, Pb nanoparticle inhibit hydroxyapatite crystal growth at least a part via down regulation of CaSR and RANK.

Key words: Inhalation, crystal, calcium sensing receptor, trabecular, cortical

Med-Science. 2017; 6(1): 46-50