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The analysis of patients under mechanical ventilation support in ıntensive care unit with the diagnosis of H1N1 infection: retrospective study

Original Article

The analysis of patients under mechanical ventilation support in ıntensive care unit with the diagnosis of H1N1 infection: retrospective study

Basak Altiparmak, Ali Ihsan Uysal, Semra Demirbilek

   

Abstract
The aim of this study is to analyze the demographic data of the patients followed in intensive care unit, under mechanical ventilation support, with a proved diagnosis of H1N1 infection. Our secondary aim is to determine the similarities and differences of these data with previous outbreaks. Seventeen patients followed in anesthesiology and reanimation intensive care unit under mechanical ventilation support due to H1N1 infection were conducted in the study. The diagnosis was proved with reverse transcription polymerase chain reaction and virus culture. Patients’ ages, comorbidities, vaccination stories, complications, mechanical ventilation period and pathological laboratory results were retrospectively recorded. Nine of the patients were male and mean age was calculated as 58.6 ± 19.4. Most common comorbidities were chronic obstructive pulmonary disease, hypertension and diabetes mellitus. Mean duration for onset of respiratory insufficiency was 9.2 ± 3.9 days. The duration was significantly lower in elderly patients. Most frequently seen complication at mechanically ventilated patients was acute respiratory distress syndrome and septic shock. Mean period for mechanical ventilation support was calculated as 15.9 ± 9.2 days. There was a weak correlation between age and mortality. When we analyzed the laboratory results, all patients’ creatine kinase levels were found to be high. We found our patients to have a long mechanical ventilation period. Older patients were shown to have a higher risk for mortality. The risk groups should be well known and vaccination programmes should be increased to prevent complications.

Key words: Influenza A, intensive care unit, mechanical ventilation

Med-Science. 2017; 6(3): 389-92

 
Medicine Science Vol:6 Issue:3 Year:2017 PP:389-613

Vitamin D and pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10 in Peritoneal Dialysis Patients

Original Article

Vitamin D and pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10 in Peritoneal Dialysis Patients

Ibrahim Orman, Hulya Taskapan, Mehmet Cagatay Taskapan, Fatma Ozyalin, Irfan Kuku

   

Abstract
Several clinical trials in patients with chronic disease have found that active vitamin D usage lowers pro-inflammatory cytokines. The aim of this study was evaluate whether supplementation of cholecalciferol in peritoneal dialysis patients with vitamin D deficiency would lead any chance in the pro-inflammatory cytokine IFN-γ and the anti-inflammatory cytokines IL-4 and IL-10, and pentraxin 3 and peripheral blood mononuclear cell subpopulations (CD3, CD4, CD8, CD45)and CD4/CD8 ratio. We analyzed fasting blood samples from 31 continuous peritoneal dialysis patients (14 males, 16 females, mean age 48,6±14,8 yrs) for serum 25-hydroxyvitamin D [25(OH)D)] and specific plasma cytokine concentrations (interferon-gamma [IFN-γ], interleukin [IL]-4, and IL-10), pentraxine 3, CD3, CD4, CD8 and CD45 before and after cholecalciferol replacement. Before and after cholecalciferol replacement mean 25 (OH) level was 6,1±2,1 ng/dL and 39,7±10,9 ng/dL respectively (p

Key words: Dialysis, Vitamin D, pro-inflammatory cytokines, anti-inflammatory cytokines, peripheral blood mononuclear cell subpopulations

Med-Science. 2017; 6(3): 393-7

 

Distribution of plantar pressure in fibromyalgia patients

Original Article

Distribution of plantar pressure in fibromyalgia patients

Tulay Yildirim, Yuksel Ersoy

   

Abstract
Fibromyalgia is a disease in which postural control and balance is impaired and tendency to falls increases. The aim of this study is to detect the presence of plantar loading impairment and to evaluate the relationship between potential plantar pressure changes and clinical signs in fibromyalgia syndrome patients. Thirty-eight female fibromyalgia patients and age and gender-matched 33 healthy controls were included in the study. Diagnosis of fibromyalgia was done based on ACR criteria. Visual Analogue Scale(VAS) and the Fibromyalgia Impact Questionnaire(FIQ) were used to determine the clinical condition of the patients. Static baropodometric measurements were performed to determine the distribution of plantar pressure. Statistically significant differences were not found between two groups regarding static baropodometric measurements (p>0.05). Inferior peak pressures in forefoot and hindfoot were associated with higher FIQ and VAS scores (p

Key words: Fibromyalgia, baropodometer, postural balance, plantar pressure

Med-Science. 2017; 6(3): 398-400

 

Caveolin-1 gene expression in rats model of chronic renal failure

Original Article

Caveolin-1 gene expression in rats model of chronic renal failure

Berna Ozyazgan, Muslum Akgoz, Yilmaz Cigremis

   

Abstract
In this study, gene expression profile of caveoline and the kidney MDA levels and serum BUN and creatinine levels were investigated in experimentally induced renal failure case of rats. In the experimental group, rats were injected with 30 mg/kg of cyclosporin A via subcutaneous route for 28 days. In the control group, rats were injected with cremophor EL, vehicle for cyclosporin A, for 28 days. Caveolin gene analysis and MDA analysis in the kidney tissue as well as serum BUN and creatinine analysis were performed at the end of the experiment. Caveolin gene expression of experimental group was significantly reduced (P < 0.05), while the MDA level was significantly increased compared to those of control (P < 0.05). Serum BUN and creatinine levels were significantly increased in the experimental group compared to the control group (P < 0.05). In the Cyclosporin A induced chronic renal failure model, we suggest that the induction of the Cav-1 gene expression may prevent the renal tissue damage.

Key words: Chronic renal failure, caveolin, cyclosporine A, MDA

Med-Science. 2017; 6(3): 401-5

 

Evaluation of fundus findings in preeclampsia [Preeklampside fundus bulgularının değerlendirilmesi]

Original Article

Evaluation of fundus findings in preeclampsia [Preeklampside fundus bulgularının değerlendirilmesi]

Erdem Dinc, Mustafa Vatansever, Ozer Dursun, Fatma Merve Bozkurt, Ayse Ayca Sari, Ayca Yıimaz, Ufuk Adiguzel, Ozlem Yildirim, Mehmet Atila Argin

   

Abstract
In this study aimed to evaluate of the fundus examination findings in the patients with preeclampsia. Fundus findings of 45 patients hospitalized in Mersin University Hospital due to preeclampsia and consulted with blurred vision between June 2007 and February 2016 were evaluated retrospectively. The average age of patients was 28.6 ± 6.18 years and mean gestational age was 32.95 ± 4.22. Anterior segment examination was normal in all patients. The fundus findings of thirty five patients were assessed as normal, but pathological findings were detected in ten (%22.2) patients. Unilateral or bilateral serous retinal detachment was observed in six (%60) patients. Retinal hemorrhages and exudates were seen in four (%40) patients. In addition to the fundus findings reversible posterior leucoencephalopathy syndrome was detected in 5 patients. Six patients were delivered vaginally while thirty-nine patients with cesarean section. Serous retinal detachment and fundus findings regressed after delivery in patients. The preeclampsia syndrome is a multisystem disorder and it also can affect the visual pathways. Visual symptoms in preeclampsia include photopsia, visual field defects, blurred vision and, in severe cases, serious blindness. Blurred vision is the most common visual complaint. Hypertensive retinopathy, exudative retinal detachment and cortical blindness can be seen in patients. But in fundus examination pathological findings are not observed in all of the patients admitted with vision loss. Preeclampsia related retinal findings generally resolves after delivery and no additional treatment is required.

Key words: Preeclampsia, fundus findings, serous retinal detachment

Med-Science. 2017; 6(3): 406-9

 

Effects of simple section of transverse carpal ligament on intercarpal stability in carpal tunnel surgery

Original Article

Effects of simple section of transverse carpal ligament on intercarpal stability in carpal tunnel surgery

Hakan Gurbuz, Suleyman Semih Dedeoglu, Yunus Imren, Ali Cagrı Tekin, Mustafa Caglar Kir, Yasin Guler

   

Abstract
The aim was to evaluate effects of simple section of transverse carpal ligament on intercarpal stability by radiological parameters in patients with carpal tunnel syndrome those are refractory to conservative treatment. Patients with suspected diagnosis of carpal tunnel syndrome upon medical history and physical examination underwent neurodiagnostic tests (EMG). All 47 subjects, comprising 39 female and 8 male patients, were operated, followed, and assessed by the same surgical team between January 2014 and May 2015 after written informed consent was obtained. Wrist range of motion and general physical examination findings were recorded at both preoperatively and postoperative week 8. Besides, conventional MRI were obtained at the same time points. Trapeziohamate distance, scaphopisiform distance, scapholunate angle, and carpal angle were measured preoperatively and at 12thweek postoperatively. The mean age of the subjects was 49(range: 36-65).Mean preoperative trapeziohamate distance was measured as 25.2 mm (range:20-33), while postoperative trapeziohamate distance was 26.4 mm (range:22-34), (p=0.031). Mean preoperative scaphopisiform distance was 32 mm (range:23-34), as compared to postoperative scaphopisiform distance being 33.6 mm (range:24- 36) (p=0.001). While mean scapholunate angle was 44°(range: 36-60) preoperatively, it was measured as 45.1° (range: 33-60) in the postoperative period (p=0.001). Both preoperative and postoperative mean carpal angles was 127° (range 118-134 and 119-134, respectively). Simple section of transverse carpal ligament is associated with a significant increase in carpal arch distance. We consider that whether or not increases in intercarpal distances may lead to a degenerative process at the wrist in future warrants further research.

Key words: Instability, carpal tunnel syndrome, magnetic resonance imaging, carpal bones

Med-Science. 2017; 6(3): 410-4

 

Multislice computed tomography findings of omental infarction as a rare cause of acute abdominal pain

Original Article

Multislice computed tomography findings of omental infarction as a rare cause of acute abdominal pain

Mustafa Koc, Selami Serhatlioglu

   

Abstract
The aim of the present study was to evaluate multislice computed tomography (MSCT) findings of omental infarction, a rare cause of acute abdominal pain, together with a review of the current literature. The retrospective cross-sectional study included eighteen patients, between 2011 and 2015, who were admitted to our department with complaints of acute abdominal pain and who were subsequently diagnosed with omental infarction. Of these eleven patients, five (61%) were males and seven (39%) were females. The mean age was 48 years, ranging from 39 to 71 years. Radiologic imaging showed findings consistent with omental infarction localized to the ascending colon in six cases, descending colon in five cases, neighborhood of transverse colon in five patients, and neighborhood of the gall bladder in two patients. The size of the lesions ranged from 3 cm to 7 cm. Abdominal MSCT showing whirling pattern of vessels in the infarcted omental vessels and an oval-shaped “dirty fat ball” appearance with well-defined margins in the neighborhood of the colon. MSCT is superior to ultrasonography in the evaluation of omentum also allows rapid and accurate diagnosis of omental infarction and prevents unnecessary surgical interventions.

Key words: Omental infarction, acute abdomen, ultrasonography, multislice computed tomography

Med-Science. 2017; 6(3): 415-7

 

Adipocytokine levels in benign prostate hyperplasia and prostate cancer patients

Original Article

Adipocytokine levels in benign prostate hyperplasia and prostate cancer patients

Gokhan Temeltas, Funda Kosova, Talha Muezzinoglu, Zeki Ari

   

Abstract
The occurrence of prostate cancer in men is one of the most common types of cancer. Recent studies have found important links between cancer and adipocytokines. Adipocytokines are thought to be factors in the occurrence of a variety of diseases. In addition, adipocytokines studies in cancer patients have shown that these hormones may have an effect in the formation of cancer. The objective of this study was to evaluate the relationship between adiponectin, resistin, and leptin levels in BHP and prostate cancer patients. The study was conducted between September 2012 and April 2013 at the Department of Medical Biochemistry and the Department of Urology. Blood samples were collected from 20 people in the same age range who had been diagnosed by examination and biopsy as having BHP (benign prostatic patients) and prostate cancer patients who had not been operated on. Leptin, adiponectin, resistin, and human serum levels were measured using ELISA kit. In the prostate cancer group, serum adiponectin and resistin levels were significantly lower than in the BHP group. However, serum leptin levels in the prostate cancer group were not significantly different from those in the BHP group. This information and our own findings show that adiponectin and resistin, which are from the adipocytokine family, may play an important role in the progression of prostate cancer, and thus it may be possible to use them as diagnostic markers. Therefore, similar studies should be considered with a greater number of patients at different stages.

Key words: Benign prostatic hyperplasia, prostate cancer, adipocytokines, leptin, adiponectin, resistin

Med-Science. 2017; 6(3): 418-23

 

The importance of procalcitonin in early diagnosis of sepsis

Original Article

The importance of procalcitonin in early diagnosis of sepsis

Funda Yetkin, Sibel Altunisik Toplu

   

Abstract
Despite the advances and a wide range of studies conducted, sepsis is one of the most frequent causes of death in patients with critical health condition. Early diagnosis, rapid and effective treatment are extremely important. Use of procalcitonin (PCT) for this purpose has become widespread and notable recently. Procalcitonin is an important test as “point-of-care testing (POCT)” just like C-reactive protein (CRP). Procalcitonin is the prohormone of calcitonin. It is released from the parenchymal cells of the liver, kidneys and muscles, and in response to bacterial toxins, it is released from the adipocytes. As a response to bacterial infection, the serum procalcitonin level may increase by 5000-fold within 2-4 hours. C- reactive protein is synthesized in the liver as a result of interleukin-6 (IL-6) trigger due to tissue injury, inflammation and/or infections. The aim of our study was to emphasize the importance of PCT as an indicator in patients suspicious of sepsis in the early period. A total of 66 patients with critical situation were included in the study conducted at the İnönü University Medical Faculty Turgut Özal Medical Center Investigation Hospital between February 2007 and August 2008. These patients were appropriate for the diagnostic criteria of systemic inflammatory response syndrome (SIRS). Appropriate antibiotiotherapy was begun for the patients. The PCT and CRP levels were investigated on the first day after having been included in the study, and on the third and seventh days. The mean C-reactive protein levels were 132.41, 108.39 and 83.47 mg/l on the 1st, 3rd and 7th days, respectively. The minimum level of procalcitonin was 0.095 ng/ml on the first day, and the maximum level was 316.054 ng/ml. The minimum/maximum levels were 0.091 and 306.043 ng/ml on the 3rd day, and 0.081 and 12.15136 ng/ml on the 7th days, respectively. No statistically significant difference was observed betweern the serum procalcitonin levels on the 1st and the 3rd days ( p

Key words: Procalcitonin, early diagnosis, sepsis

Med-Science. 2017; 6(3): 424-6

 

Clinical outcomes of scaphoid nonunions treated with 1,2 intercompartmental supraretinacular artery pedicled vascularized bone graft and headless compression screw

Original Article

Clinical outcomes of scaphoid nonunions treated with 1,2 intercompartmental supraretinacular artery pedicled vascularized bone graft and headless compression screw

Okan Aslanturk, Emre Ergen, Metehan Ozen, Kadir Ertem

   

Abstract
Scaphoid fractures are the most common fracture of the carpal bones and account for 60% carpal injuries. Nonunion may occur in 5-12% of scafoid fractures. Aim of this study is to present result of scaphoid nonuinon treated with 1-2 intercompartmental pedicled artery bone graft and canullated screw in our clinic. Between 2009-2012, 19 scaphoid nonunions ( 18 males, 1 female) were treated with 1-2 intercompartmental pedicled artery bone graft and canullated screw. The average age of patients were 31,2 (range 12-47 years). The average time from initial injury to operation was 40.8 months (range 8 months -20 years).All scaphoid nonunions healed with union at an average of 9,4 weeks( range 6-12 weeks) after surgery. The average Mayo score of patients were 76,6 (range-25-100). We determined that treatment with 1-2 intercompartmental pedicled artery bone graft and canullated screw is good option in scaphoid nonunions regardless of avascular necrosis.

Key words: Scaphoid nonunion, pedicled vascularized bone graft, compression screw

Med-Science. 2017; 6(3): 427-30