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C-Reactive protein to albumin ratio to predict postoperative complications after gastrectomy for gastric cancer

Original Article

C-Reactive protein to albumin ratio to predict postoperative complications after gastrectomy for gastric cancer

Seref Dokcu, Mehmet Ali Caparlar

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Abstract

The aim of the study was to evaluate the availability of C-reactive protein / albumin ratio (CRP/ALB) in the prediction of postoperative complications after gastrectomy for gastric cancer. The primary outcome measure was to find out whether an association exists between postoperative major complications and common predictive measures. The secondary outcome measures were to compare predictive measures in patients with or without major complications. After obtaining hospital’s ethic committee approval medical data were obtained using electronic medical database and medical files of patients who underwent resection surgery for gastric cancer between 2015 and 2020. The inclusion criteria were adult patients and elective primary surgery. Patients with metastatic gastric cancer, urgent surgery, liver cirrhosis, previous infection, lost to follow-up, and insufficient data were excluded. Of 200 patients who were included in the study, 18 patients had major postoperative complications including anastomotic leakage in 7 (3.5%) patients, intestinal obstruction in 5 (2.5%) patients, intraabdominal abscess in 5 (2.5%) patients, pleural effusion in 1 (0.5%) patient. As a result of univariate and multivariate analysis, elevated CAR (OR 3.73; 95% CI 2.02-8.13; p=0.01) and CRP levels (OR 2.82; 95% CI 1.34-7.61; p=0.02) at postoperative 3. days were found as independent predictors for major complications. The patients with major complications were admitted more likely to intensive care unit (77.8% vs. 30.7%; p=0.017) and mean discharge time was longer (16.7±4.9 days vs. 7.9±2.4; p=0.021). CRP to ALB ratio and CRP levels at the postoperative 3. day were found to be independent predictors of major complications after gastrectomy for gastric cancer.

Key words: Albumin, complication, C-reactive protein, gastrectomy, gastric cancer

Med-Science. 2021; 10(4): 1087-91
 
Medicine Science Vol:10 Issue:4 Year:2021 PP:1087-1567

Nasolacrimal duct obstruction with obstructive nasal deformity; is synchronous nasal surgery necessary?

Original Article

Nasolacrimal duct obstruction with obstructive nasal deformity; is synchronous nasal surgery necessary?

Yuksel Toplu, Tuba Bayindir, Mehmet Balbaba, Mahmut Tayyar Kalcioglu, Emrah Sapmaz, Erkan Karatas.

Abstract

The aim of this study was to evaluate the necessity of the simultaneous additional nasal surgery to increase success rate of the endoscopic dacryocystorhinostomy operation, in the patients with nasolacrimal duct obstruction and obstructive nasal deformity. One hundred and thirty patients with nasolacrimal duct obstruction and obstructive nasal deformity (59 were female and 71 male, age ranged between 31 and 82 years, mean=60.3 years) were included in this study. Patients with nasolacrimal duct obstruction were divided into two main groups (group A and B) and six subgroups (A1, A2, A3 and B1, B2, B3) according to the presence of obstructive nasal deformity and applied operation techniques. The success and complications rates of this groups were evaluated. The success rates of endoscopic dacryocystorhinostomy in the additional nasal surgery performed group (Group A) were not statistically significant higher than the group without additional nasal surgery (Group B). Complications rate of group A (26.08%) were statistically significant higher than group B (9.8%). In patients with complications, the average success rate of endoscopic dacryocystorhinostomy surgery (70.8%) was statistically significant lower than in patients with no complications (88.6%), respectively. Additional nasal surgery has no statistically significant effect on the success of the endoscopic dacryocystorhinostomy surgery. Developing complications was statistically affect the success rate of endoscopic dacryocystorhinostomy surgery. Due to these reasons, contrary to the general idea, we believe that, to increase the success rate of the endoscopic dacryocystorhinostomy surgery, additional nasal surgery is unnecessary in patients with nasolacrimal duct obstruction and obstructive nasal deformity.

Key words: Nasolacrimal duct obstructions, septum deviation, concha bullosa, endoscopic dacryocystorhinostomy

Med-Science. 2021; 10(4): 1092-6
 

Evaluation of cerebral microbleeds in patients using rivaroxaban for cardioembolism prophylaxis in non-valvular atrial fibrillation

Original Article

Evaluation of cerebral microbleeds in patients using rivaroxaban for cardioembolism prophylaxis in non-valvular atrial fibrillation

Sukru Sahin, Ali Haydar Baykan, Ali Zeynel Abidin Tak

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Abstract

Cerebral microbleeds (CMBs) are associated with an increased risk of ischemic and particularly hemorrhagic stroke and are considered a marker of cerebrovascular disease in cranial magnetic resonance imaging (MRI). Rivaroxaban is a new-generation oral anticoagulant and a direct inhibitor of Factor Xa. In this study, we aimed to evaluate the frequency of CMBs in patients using rivaroxaban to prevent cardiac embolism in non-valvular atrial fibrillation. Seventy-four patients using rivaroxaban and 64 controls were included in the study. The group using rivaroxaban had been using medication for at least 6 months. Susceptibility Weighted Angiography (SWAN) sequence was taken from all participants in a 1.5 Tesla MR device to detect CMBs. In the rivaroxaban group, the frequency of CMBs was significantly higher than the control group (p= 0.028), and it increased with the increasing duration of rivaroxaban use (p=0.005). Also, in the rivaroxaban group, there was the frequency of CMBs in specific areas such as the frontal lobe, basal ganglia, and thalamus compared with the control group participants. Since it is known that presence of CMBs increase the risk of stroke, we conclude that caution should be taken in patients who are on rivaroxaban for prophylaxis of cardiac thromboembolism. However, we also believe that this finding needs to be confirmed in studies including larger patient series.

Key words: Cerebral microbleeds, magnetic resonance imaging, atrial fibrillation, rivaroxaban, stroke

Med-Science. 2021; 10(4): 1097-102
 

Pharmacological and biological features of ethanol extract of Salvia virgata Jacq

Original Article

Pharmacological and biological features of ethanol extract of Salvia virgata Jacq

Merve Ergul, Mehmet Atas, Halil Bal, Esra Ucar, Nuraniye Eruygur, Belgin Cosge Senkal, Tansu Uskutoglu

Abstract

Salvia virgata as an ethnomedicinal plant comprehends a variety of efficient active ingredients and shows diverse pharmacological actions, such as anti-proliferative, anti-inflammatory, and antimicrobial effects. In this study we aimed to determine the biological content of the ethanolic extract of S. virgata and to determine its possible pharmacological effects. The broth microdilution technique was carried out for determining antimicrobial activities, and the test microorganisms included E. coli, S. aureus, B. cereus, P. aeruginosa, C. albicans, and C. tropicalis. DPPH and ABTS methods were used to detect antioxidant activity. The XTT cell viability test was utilized to assess the antiproliferative activity of the ethanolic extract of S. virgata on L929 and MDA-MB-231 cell lines. S. virgata exhibited reasonable antimicrobial effects against E. coli (0.312 mg/mL) and S. aureus (0.312 mg/mL). DPPH and ABTS IC50 values were determined 291.58 ± 0.004 μg/mL, 16.74 ± 0.007 μg/mL respectively. S. virgata ethanolic extract TPC and TFC were observed 283.35 ± 10.4 mg GAE/g and 13.37 ± 1.6 mg QE/g, respectively. The extract was screened against α-amylase and α-glucosidase, AChE, and BChE enzymes, and inhibition activity was determined 75.73%, 62.72%, 67.19%, 3.18% respectively. The extracts did not significantly affect the L929 cell viability, while MDA-MB-231 remarkably reduced cell viability (IC50 = 0.118 mg/mL). The ethanolic extract of S. virgata can be considered as a potential therapeutic agent in the treatment of different pathological conditions due to its antimicrobial, antioxidant, and anticancer effects.

Key words: Salvia virgata extract; antimicrobial; antioxidant; enzyme inhibition; antiproliferative

Med-Science. 2021; 10(4): 1103-9
 

How technology addiction affects social anxiety in adolescent girls? A sample of Turkey’s southeast

Original Article

How technology addiction affects social anxiety in adolescent girls? A sample of Turkey's southeast

Behiye Dilmen Bayar, Funda Kavak Budak

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Abstract

The purpose of this study was to determine the how technology addiction affects social anxiety in adolescent girls. Sample of this correlational descriptive study was conducted with 635 female students determined by power analysis in five high schools located in a province. The data were collected using the Descriptive Characteristics Form, Social Anxiety Scale for Adolescents, and Technology Addiction Scale. Total mean score of the adolescent girls was found to be 50.52±20.47 for technology addiction and 41.98±13.71 for social anxiety. It was determined that technology addiction and social anxiety of the adolescent girls were moderate. There was a positive correlation between total mean score of technology addiction and total mean score of social anxiety (p=0.00, r=0.20). In the study, it can be said that as social anxiety increases, technology addiction increases, or as technology addiction increases, social anxiety also increases. It can be recommended for psychiatric nurses to provide necessary trainings to reduce technology addiction and social anxiety and to develop methods for coping with social anxiety in secondary education institutions.

Key words: Adolescent, girls, social anxiety, technology addiction

Med-Science. 2021; 10(4): 1110-6
 

The comparison of telomere length in cancer patients: Plasma, whole blood and tumor tissue

Original Article

The comparison of telomere length in cancer patients: Plasma, whole blood and tumor tissue

Mine Urfali, Fatma Silan, Furkan Erturk Urfali, Atila Gurgen, Ozturk Ozdemir

Abstract

Telomer dysfunction triggers numerical and structural chromosomal instability and initiates tumorigenesis. Classical biopsies provide information about parts of tumor tissue, but cancer is divided into subgroups according to its mutational and behavioral characteristics. In this study, we aimed to investigate whether the results of cellfree-DNA were compatible with those obtained from tissues and to investigate whether cellfree-DNA telomere length is an alternative non-invasive method for the diagnosis of cancer. This study included the Q-PCR telomere measurement of tumor tissue, peripheral blood and plasma samples in patients with various cancers and peripheral blood and plasma samples of a control group. The telomeric DNA length and T/S ratios were calculated using the T/S ratio (2-ΔΔCt) formula. The median value for the plasma relative T/S ratio of the cancer group was statistically significantly higher than control group. In the cancer group, the lowest relative T/S ratio was found in plasma samples. The mean T/S ratio of whole blood was higher than tumor tissue, and similarly the relative T/S ratio of tumor tissue was higher than plasma T/S ratio(whole blood>tumor tissue>cfDNA). In cancer patients, the longer telomere length suggests that plasma cellfree-DNA telomere length could be a new molecular marker in cancer diagnosis and follow-up.

Key words: Cell-free DNA, cancer, qPCR, telomere length

Med-Science.

2021; 10(4): 1117-21
 

Morphometric alteration induced by cyclophosphamide in rat kidney and protective efficacy of coenzyme Q10: A stereological study

Original Article

Morphometric alteration induced by cyclophosphamide in rat kidney and protective efficacy of coenzyme Q10: A stereological study

Ahmad Yahyazadeh

Abstract

Cyclophosphamide (CD), as a chemotherapeutic drug, is used for the elimination of cancer cells, but its toxicity has led to health problems. We aimed to investigate the efficacy of coenzyme Q10 (C10) on kidney alterations caused by CD treatment in Wistar albino rats. Thirty-five adult male rats were assigned into five groups: control (CO), olive oil (OO), CD, C10, and CD+C10. All kidney tissues were analysed using the stereological and histopathological techniques. Stereological results revealed that the mean volumes of kidney, cortex, medulla, and glomerulus were significantly increased in the CD group than the CO group (p < 0.05). We also observed a significant decrease in the mean volume of proximal tubules in the CD group than the CO group (p < 0.05). In the CD+C10 group, the mean volumes of kidney, cortex, medulla, and glomerulus were significantly less when compared to the CD group (p < 0.05). In addition, there was a significant increase in the mean volume of proximal tubules in the CD+C10 group than the CD group (p < 0.05). Histopathological examination also revealed valuable results. Our findings showed that treatment with CD caused destructive change in the rat kidney tissues. Moreover, C10 administration significantly attenuated the toxic effect of CD on the kidneys.

Key words: Coenzyme Q10, cyclophosphamide, kidney, rat

Med-Science. 2021; 10(4): 1122-7
 

Determination of the prevalence of dental anomalies by digital panoramic radiography analysis

Original Article

Determination of the prevalence of dental anomalies by digital panoramic radiography analysis

Mihriban Gokcek Tarac, Neslihan Yilmaz Cirakoglu

Abstract

Abstract
To determine the prevalence of dental abnormalities and which dental anomalies are more common in Turkish society by evaluating panoramic radiographs. This study is based on a retrospective examination of randomly selected panoramic radiographs of 2500 patients who applied to Karabük Oral and Dental Health Hospital during 2016-2020 years. Dental anomalies were evaluated by dividing them into 5 types and 16 subtypes. Also, data such as age and gender of the patients were found from the patient records and noted. The average age of the patients was 34.5 (range 6-45) years; 1167 (46.68 %) patients were male and 1333 (53.32 %) were female. Of the 2500 patients, 817 had at the lowest one type of dental anomaly; so the prevalence of dental anomaly in the research community was calculated at 32.68% (43% of these were men, 57% were women). Amongst them of 750 (91.79%) patients had one type of anomaly, 61 (7.46%) had two types of anomalies, and 6 (0.75%) had three types of anomalies. Dental anomalies are quite common disorders of teeth. Although even not to show any symptom, they can induce very kind of practical complication. The high rate of dental anomalies shows the importance of detecting dental anomalies.

Key words: dental anomaly; panoramic radiography; tooth malformation

Med-Science. 2021; 10(4): 1128-32
 

Comparison of efficacy and toxicity of treosulfan-fludarabine and busulfan-cyclophosphamide conditioning regimens in patients undergoing allogeneic stem cell transplantation

Original Article

Comparison of efficacy and toxicity of treosulfan-fludarabine and busulfan-cyclophosphamide conditioning regimens in patients undergoing allogeneic stem cell transplantation

Ahmet Sarici, Mehmet Ali Erkurt, Irfan Kuku, Omer Faruk Bahcecioglu, Selim Gok, Soykan Bicim, Ilhami Berber, Emin Kaya

Abstract

In hematologic malignancy patients undergoing allogeneic HSCT, the optimal conditioning regimen is uncertain and comparative studies of conditioning regimens with each other are needed. In the current study, it was intended to compare the toxicity profile of two myeloablative conditioning regimens (treosulfan-fludarabine vs busulfan-cyclophosphamide) and their effects on clinical outcomes. The data of patients who underwent allogeneic HSCT between 2015 and 2020 in Inonu University Turgut Ozal Medical Center were retrospectively analyzed. Patients receiving treosulfan-fludarabine (treosulfan group) or busulfan-cyclophosphamide (busulfan group) as a conditioning regimen prior to allogeneic HSCT were matched 1:1 according to their disease and age. A total of 42 patients were included in this trial (busulfan:21, treosulfan:21). The mean age of the patients was 45.2±14 years, and regimen-related toxicities and clinical outcomes of both groups were similar (all p>0.05). The median follow-up time of the patients in the treosulfan regimen groups was 9 months, while it was 15 months in the busulfan regimen group (p=0.82). 54.8% of the patients (12 treosulfan, 11 busulfan) died after a median follow-up of 9.5 months. When the effects of the two conditioning regimens on were compared in 28 acute myeloid leukemia (AML) patients, the engraftment times, acute and chronic graft versus host disease incidences, and sinusoidal obstruction syndrome incidence were found to be similar in busulfan and treosulfan groups (all p>0.05). In addition, the estimated median progression-free survival (p=0.938) and overall survival (p=0.672) of the groups were similar. Treosulfan-fludarabine appears to be a conditioning regimen that can be used as an alternative to busulfan-cyclophosphamide. Prospective randomized studies are needed to confirm the data in our study.

Key words: Busulfan; treosulfan; allogeneic transplantation; conditioning regimen

 

The suicidal deaths in Isparta: A 10-year retrospective autopsy study

Original Article

The suicidal deaths in Isparta: A 10-year retrospective autopsy study

Abdulkadir Yildiz, Ozge Savci, Ibrahim Eroglu, Erdinc Cayli

Abstract

Although suicide constitutes a critical social and health problem, it is a preventable death cause. The present study aimed to provide epidemiological data to the programs that can be developed to determine and prevent suicide risk through the retrospective examination of 126 suicide-originated autopsies conducted between 2010 and 2019. The mean age was 41.40±19.58 years. 18-40 age group had the highest incidence for both sexes. The male-female ratio was 2.5:1. Data obtained in this study showed that although the home was the most common location and hanging was the most common method of suicide, a statistically significant difference was found in the distribution of suicide locations and methods based on sex (p<0.05). There was a statistically significant difference only in firearm use in the distribution of suicide methods based on age groups. The firearm was used by 38.5% of pediatric cases. Menstrual bleeding was detected in 56.5% of women of reproductive age. Almost half of the relatives (48.4%) did not know that the decedents had problems leading to suicide. 24.6% of the cases had a psychiatric diagnosis, which was depression, in 51.6%. Access to children to firearms is thought-provoking, especially in adolescent suicides. Important legal restrictions and punishments on the supply and possession of firearms and raising public awareness are necessary. One of the most striking findings of this study was that nearly half of the relatives did not know that the decedent had a problem leading to suicide. Unawareness of suicide clues by the relatives constitutes an important problem causing the deprivation of psychosocial support for the individuals and shows that training programs for society are needed to prevent suicide.

Key words: Forensic autopsy, suicide, suicide methods, risk factors, menstrual cycle

Med-Science. 2021; 10(4): 1138-44