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Frequency of lysosomal acid lipase deficiency in patients with primary hyperlipidemia

Original Article

Frequency of lysosomal acid lipase deficiency in patients with primary hyperlipidemia

Bahri Evren; Yilmaz Bilgic; Feyza Firat Atay; Ayse Nuransoy Cengiz; Yasir Furkan Cagin

   

Abstract
The aim of our study was to investigate the prevalence of LAL (lysosomal acid lipase) deficiency in patients with primary hyperlipidemia. Twenty-four patients with primary hyperlipidemia were included in the study. The gender, age, height, weight, body mass index and waist circumference of the patients were recorded. Lipid profiles, glucose, transaminases and LAL enzyme profiles were evaluated. LAL enzyme deficiency was not detected in patients with primary hyperlipidemia. In our study, when we investigated LAL deficiency in primary hyperlipidemic patients, we could not find a relationship between them. As a result of our study, LAL deficiency was not detected in patients with primary hyperlipidemia. However, in this context, there is a need to work with a large number of patients.

Key words: Primary hyperlipidemia;lysosomal acid lipase deficiency

Med-Science. 2019; 8(2): 260-2

 

Medicine Science Vol:8 Issue:2 Year:2019 PP:260-488

Can nutritional status of patients in intensive care unit predict mortality and length of hospital stay? A single center retrospective case control study

Original Article

Can nutritional status of patients in intensive care unit predict mortality and length of hospital stay? A single center retrospective case control study

Deniz Avci; Ali Cetinkaya; Yekta Gulunay; Sadik Oluk; Abdullah Eyvaz

   

Abstract
To compare the hospitalization duration and mortality with the first day nutritional status of the patients who were hospitalized in intensive care unit of internal medicine department. The files of patients admitted to the ICU between 01-January-2017 and 30-June-2017 were retrospectively reviewed. Those who were not eligible for study in the selected files were later handed off. The remaining patients (169 patients) were evaluated for age, sex, stay in intensive care unit, APACHE2 and Glasgow scores, outcomes (exitus or discharge), NRS-2002 values in day of hospitalization, glucose, creatinine, albumin, White Blood Cell, hematocrit, thrombocyte, C-reactive protein and thyroid stimulating hormone (TSH) values were recorded. In addition, patients need for mechanical ventilation and underlying diseases (Chronic renal failure, cancer, sepsis, etc.) were recorded. The mean NRS-2002 score of the whole group was 4.28±0.90. The mean NRS-2002 score of discharged patients was 3.98±0.80 while the mean NRS-2002 score was 4.71±0.86 (p

Key words: NRS-2002;Mortality;intensive care unit;nutrition

Med-Science. 2019; 8(2): 263-7

 

Is childhood trauma a predictive factor for increased preoperative anxiety levels?

Original Article

Is childhood trauma a predictive factor for increased preoperative anxiety levels?

Ayse Vahapoglu; Suna Medin Nacar; Yagmur Suadiye Dalgic; Hande Gungor

   

Abstract
Childhood trauma is a well-known source of lifelong anxiety and various personality disorders. Also preoperative anxiety is related with perioperative physical and physicological responses. The aim of this study was to investigate possible relationship –which has not been studied yet- between having a childhood trauma history and preoperative anxiety levels. A total of 190 patients (aged between 18-65) with a history of childhood trauma presenting for different types of surgery were investigated prospectively using the Childhood Trauma Questionnaire (CTQ). A childhood trauma questionnaire total score of ≥35 points was accepted as an indicator of significant childhood trauma history. Preoperative and postoperative anxiety levels of patients were assessed using State Trait Anxiety Inventory (STAI). Also relationship between childhood trauma types (physical, emotional neglect/abuse, sexual abuse) and pre-postoperative State Trait Anxiety Inventory levels were evaluated. Correlations between several factors that might effect preoperative anxiety levels including such as; gender, type of surgery, type of anesthesia, educational and maritial levels of patients with or without a childhood trauma history were investigated. We found significant correlations between higher Childhood Trauma Questionnaire scores and increased preoperative State Trait Anxiety Inventory trait and state scores (p

Key words: Preoperative anxiety;childhood trauma;childhood trauma questionnaire;state trait anxiety inventory

Med-Science. 2019; 8(2): 268-73

 

Our experience and results of clinical incidental gallbladder carcinomas

Original Article

Our experience and results of clinical incidental gallbladder carcinomas

Oguz Catal; Bahri Ozer; Mustafa Sit

   

Abstract
This study aimed to eveluate our experience in incidental gallbladder carcinomas the effect of resection on life time .We suggest that liver resection may contribute to the disease free survival of the patients with incidental gallbladder carcinomas. Between January 2012 and December 2017, 3691 patients who underwent cholecystectomy in the Department of General Surgery of Abant Izzet Baysal University Medical Faculty and who did not consider biliary stricture in their preoperative evaluation were evaluated retrospectively.Patients were grouped according to age, sex, stone size, bile duct wall thickness and histopathological results. The preoperative diagnosis of all patients undergoing cholecystectomy was cholelithiasis. Of the 3691 patients, gallbladder cancer was detected in the evaluation of the pathology specimens of 16 patients (0.50%)Of the patients who were diagnosed with gallbladder carcinomas, 12 had female gender and 4 had male gender . All of the patients were found to have adenocarcinoma when the pathology specimens were examined. In the pathology specimens, 2 patients had carcinoma insitu, 2 patients had T1, 5 patients had T2, 7 patients had T3. In this study we share our experience in incidental gallbladder carcinomas and suggest that liver resection may contribute to the disease free survival of the patients with incidental gallbladder carcinomas.

Key words: Incidental gallbladder carcinomas;gallbladder stones;liver resection;disase free survival;cholecyctectomy

Med-Science. 2019; 8(2): 274-6

 

Assessment of readability level of informed consent forms used in intensive care units

Original Article

Assessment of readability level of informed consent forms used in intensive care units

Munise Yildiz; Betul Kozanhan; Mahmut Sami Tutar

   

Abstract
Informed consent forms are printed forms prepared to assist patients in the treatment process by explaining the indications, benefits and possible risks of medical practices. Readability describes understanding difficulty and is calculated by mathematical formulas. The study aimed to assess the readability level of “Informed Consent Forms” used in intensive care units. The informed consent forms from 45 hospitals in our country have been gathered. In each average form number of words, the average number of syllables and the average number of words with 4 or more syllables were manually calculated using the “Microsoft Office Excel 2016®” program. Their readability levels have been assessed with Atesman and Bezirci-Yilmaz readability formulas. The readability level of forms was “difficult” according to the Atesman readability formula and at “undergraduate level” according to the Bezirci-Yilmaz readability formula. The readability level of forms used in private hospitals was found to be significantly lower than that used in state and university hospitals (p=0.019, p=0.012). The average number of words and the average number of words with 4 or more syllables in forms were found to be significantly higher in private hospitals compared to state and university hospitals (p=0.004, p=0.01). It has been determined that the readability level of informed consent forms was at academic literacy level. To protect patient rights and to regulate patient-physician relationships by taking into account individuals rights, informed consent forms should be reviewed and that their readability levels should be adjusted to cover the overall educational level of individuals in the general population.

Key words: Intensive care;informed consent form;readability

Med-Science. 2019; 8(2): 277-81

 

The contribution of implantable cardioverter defibrillators to systemic inflammation in heart failure patients

Original Article

The contribution of implantable cardioverter defibrillators to systemic inflammation in heart failure patients

Ozcan Orscelik; Bugra Ozkan; Mert Koray Ozcan

   

Abstract
Heart failure (HF) is associated with an increased ‘inflammatory burden’, which is manifested by the elevation of serum levels of some inflammatory mediators such C-reactive protein (CRP), cytokines. In addition, high levels of inflammatory markers in patients with HF have been associated with poor outcomes. Lethal ventricular arrhythmias such as asystole and ventricular fibrillation-tachycardia are common in patients with HF and implantable cardioverter defibrillators (ICDs) are effective in preventing these situations. But like every foreign object in the body, ICDs also cause fibrosis and inflammation. This study aimed to show additional contribution of ICDs to systemic inflammation in patients with HF. This is a single centrer retrospective study included 140 HF patients with and without ICD (group 1 and 2) and 53 healty control subjects (group 3). Three groups were compared with regard to Hs-CRP and Neutrophil / Lymphocyte ratio (NL ratio). In order that acute inflammation did not affect the results, the earliest 6th month laboratory measures after ICD implantation were recorded. There are not significant difference between all groups in terms of age and gender, and among group 1 and 2 in terms of disease history, ejection fraction, heart rate and creatinine. When compared to the three groups according to Hs-CRP and NL ratio, there was a significant difference between the groups (both p

Key words: Systemic inflammation;implantable cardioverter defibrillators;heart failure

Med-Science. 2019; 8(2): 282-6

 

An investigation of speech sounds of patients applied to orthodontics clinic

Original Article

An investigation of speech sounds of patients applied to orthodontics clinic

Guzin Bilgin Buyuknacar; Aysegul Gulec

   

Abstract
The aim of this study is to determine the sound characteristics of speech sounds of patients applied to orthodontics clinic to understand how speech will be affected after orthodontic treatment. The study included 60 patients (35 females, 25 males; 13.60±2.35 years) Fricatives (/f/, /s/, /s/) were selected for spectral center of gravity analysis. Sounds were examined under four groups: syllable-initial, syllable-final, /a/ context and /i/ context. The Shapiro Wilk test and Mann-Whitney U-test, were used for statistical evaluations. There was a statistically significant difference between syllable-initial and syllable-final measurements of /f/ sound (p=0.008). There was a significant effect of gender in all groups of /s/ sound and syllable-initial group of /s/ sound (p

Key words: Speech sounds;speech acoustics;orthodontics

Med-Science. 2019; 8(2): 287-290

 

Prevalence of dysmenorrhea in young women and their coping methods

Original Article

Prevalence of dysmenorrhea in young women and their coping methods

Aynur Kizilirmak; Bahtisen Kartal; Pelin Calpbinici

 
 Cited by (1) 

Abstract
The study was conducted to determine the frequency of dysmenorrhea in young women and their coping methods. The study was conducted at 2014-2015 education year, spring semester of a university as descriptive. Total 3526 girl students consisted of the universe. Sample size table was used for sample choosing and sample size was determined as 600 participants with 0.03 sample error and p = 0.08. A questionnaire form that improved by the researcher and Visual Analogue Scale (VAS) were used. It is determined that average age of the students was 20.58±1.73, 65.0% lived at hall of residence, 8.7% smoked and 3.5% used alcohol. Of them; average age of menarche was 13.45±1.17, 68% had 3-6 days for menstrual period, 48.5% had 28-33 days for menstrual cycle, 15.3% lived menstrual irregularity. Also, 93.3% lived dysmenorrhea, mean of severity of dysmenorrheal pain was 6.33±2.69 and 24.5% of them who lived pain applied to health institute. It is found that of the girls; 63.2% used analgesic, 67.8% had rest in bed, 63.7% applied hot for foot, 56.3% applied hot for abdomen, 26.0% applied massage to abdomen for coping with dysmenorrhea. Also, 66.4% of them stated that these methods make them relax.In the study, it is found that dysmenorrheal prevalence was high in young women and they used both pharmacologic and non-pharmacologic methods for coping with it. It is suggested that informative education programs about complementary and holistic treatment approaches for young women.

Key words: Dysmenorrhea;coping methods;menstruation

Med-Science. 2019; 8(2): 291-5

 

Effect of benidipine on experimental gastric ulcers in rats

Original Article

Effect of benidipine on experimental gastric ulcers in rats

Bahadir Suleyman; Renad Mammadov; Adalet Ozcicek; Fatih Ozcicek; Mehmet Kuzucu; Durdu Altuner; Zeynep Suleyman

   

Abstract
Peptic ulcer has been reported to increase acid secretion and lead to oxidative stress. Benidipine is an antihypertensive drug with antioxidant properties. This study aims to investigate the effects of benidipine on indomethacin-induced gastric ulcers in rats. Four groups were designed in this study. Gastric ulcer was occurred with indomethacin in the first three groups. These groups were treated with famotidine, benidipine and distilled water respectively 5 minutes before indomethacin administration. The fourth group rats didnÂ’t have gastric ulcer and they received only distilled water. Six hours after drug administration gastric tissue was extracted and macroscopic and biochemical examinations were performed. Damaged areas in the stomach of benidipine and famotidine receiving animal groups were smaller than the indomethacin received animals. Indomethacin elevated the levels of malondialdehyde and myeloperoxidase in the stomach tissue (p

Key words: Benidipine;oxidant;antioxidant;gastric ulcers;rats

Med-Science. 2019; 8(2): 296-300

 

Malaria prevalence and risk analysis among pregnant women in Bungoma county, Kenya

Original Article

Malaria prevalence and risk analysis among pregnant women in Bungoma county, Kenya

Antony Wanyonyi Wekesa; Chrispinus Siteti Mulambalah; David Mulama; Elizabeth Omukunda

   

Abstract
Malaria during pregnancy has adverse consequences on the mother and fetus. Information describing the prevalence, Plasmodium species types and the influence of socio-economic risk factors of malaria in pregnancy is scarce. In order to determine the distribution of malaria parasite species and risk factors among pregnant women in Bungoma County, a cross sectional hospital based study was carried out between March 2016 and January 2017 among 750 consented expectant mothers seeking antenatal services at the Bungoma County hospital. Malaria positivity and species identification were determined microscopically using Giemsa stain technique. Socio economic risk factors were collected using a structured pre-tested questionnaire. Data was analysed using STATA version 12. Descriptive analysis was used to determine malaria prevalence. Chi-square (X2) and regression analyses were used to determine the association between malaria and risk factors with P-

Key words: Prevalence;malaria;pregnant women;socio economic risk factors

Med-Science. 2019; 8(2): 301-5