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Serum elabela levels in women with tubal ectopic pregnancy: A case-control study

Original Article

Serum elabela levels in women with tubal ectopic pregnancy: A case-control study

Evrim Gul, Rulin Deniz, Ebru Celik Kavak, Cengiz Sanli, Ibrahim Batmaz, Gulay Bulu, Salih Burcin Kavak, Yakup Baykus

   

Abstract
Elabela, a circulating peptide hormone derived from the placenta, plays a crucial role in embryonic development and function of the human placenta during pregnancy. We aimed to investigate serum elabela levels in ectopic pregnancy. Sixty cases admitted to Emergency Department and Obstetrics and Gynecology Clinic were included in this case-control study. Thirty women with tubal ectopic pregnancy constituted Group 1 and 30 women with healthy pregnancy served as controls (Group 2). Blood samples were collected from all participants. Demographic and obstetric characteristics of the whole study cohort were also recorded. Levels of serum elabela were measured in each group by enzyme-linked immunosorbent assay . Age, gender, gestational age, obstetrics history, and body mass index of the groups were similar. Mean serum elabela levels were 7.52 ± 1.1 ng/mL and 7.05 ± 1.2 ng/mL in group 1 and group 2, respectively. There was no statistically significant difference between the two groups with respect to serum elabela levels ‎ (t=1.581, p=0.119). In the present study, serum elabela levels were not significantly different in women with ectopic pregnancies than healthy pregnancies. Since placenta is the primary source of elabela, this lack of difference might be due to the insufficient placental as well as fetal development in fallopian tubes.

Key words: Ectopic pregnancy, emergency, serum Elabela

Med-Science. 2020; 9(2): 289-92

 
 
 
Medicine Science Vol:9 Issue:2 Year:2020 PP:289–525

AI in Medicine versus AI in Prehospital

Original Article

AI in Medicine versus AI in Prehospital

Ahu Pakdemirli, Asim Leblebici

   

Abstract
This study was made to compare the information about the studies on “Artificial intelligence in medicine” and “Artificial intelligence in Pre-hospital” on the Scopus database, and to investigate research on artificial intelligence in health and pre-hospital field. In the study, the studies on “Artificial Intelligence in Medicine/Prehospital,” “Machine learning in Medicine/Prehospital” and “Deep learning in Medicine/Prehospital” on Scopus database were performed to compare the information. Two groups were examined according to “Year”, “Author”, “Institution”, “Publication type”, “Field”, “Country”, “Fund institution”, “Language” and “Citation” parameters. Descriptive statistics and nonparametric Mann-Whitney-U test was used. In the studies conducted, the rate of change in the 2 screening groups was calculated around 83-84%. Although there is no statistical difference between the rate of change, it is seen that the concept of “Artificial intelligence in medicine” is used quite widely compared to “Artificial intelligence in Pre-hospital”. It is seen that, as in all areas of Artificial Intelligence and its sub-concepts, the studies carried out in the fields of health and pre-hospitals continue and will continue to increase dramatically.

Key words: Artificial intelligence (AI), prehospital, artificial intelligence in healthcare

Med-Science. 2020; 9(2): 293-7

 

Prevelance of flatfoot in secondary school students and its relationship with obesity

Original Article

Prevelance of flatfoot in secondary school students and its relationship with obesity

Mehmet Fatih Korkmaz, Mahmut Acak, Serkan Duz, Omer Bozduman

   

Abstract
The aim of this study is to determine the flatfoot prevalence of secondary school students and to investigate the relationship between obesity. As the population of the study consists of 28540 students between the ages of 10 and 18 living in Yeşilyurt and Battalgazi districts of Malatya province, the sample consisted of 3493 people, 1593 women and 1903 men. It was found that, 16.7% of women (9.8% flexible, 6.9% rigid), 16.1% of men (9.3% flexible, 6.8% rigid) had pes planus. It was determined that 19.6% of the participants had problems in their feet and 9.7% of them had flexible, 6.9% had rigid pes planus and 3% had high arch. It was observed that 31.2% of overweight participants were flexible and 15.6% were rigid pes planus while 21.2% of the obese participants were flexible and 37.7% were rigid pes planus. The mean of visual analogue scale (VAS) scores in which the participants evaluated the pain in the lower part of the leg during the day was 6.0±.08, in students with flexible pes planus and 8.5±1.11 in students with rigid pes planus. As a result of the study, no significant relationship was found between gender and flatfoot, but there was a significant relationship between flatfoot and obesity in all age groups.

Key words: Flatfoot, Secondary education, obesity

Med-Science. 2020; 9(2): 298-304

 
 
 

Synthesis and computer – aided drug design studies of novel thiosemicarbazide derivatives as potent and target – oriented anti – cancer agents

Original Article

Synthesis and computer - aided drug design studies of novel thiosemicarbazide derivatives as potent and target - oriented anti - cancer agents

Efe Dogukan Dincel, Nuray Ulusoy Guzeldemirci

   

Abstract
A series of novel thiosemicarbazide derivatives (2a-d) were synthesized from 3,5-bis(trifluoromethyl) benzohydrazide (1) and various substituted isothiocyanates. The structures of novel compounds were determined by analytical and spectral (IR, 1H-NMR, and elemental analysis) methods. In silico studies were conducted to determine and evaluate the potential anticancer activity of the compounds. Target-oriented drug design is crucial for cancer therapy for increasing the selectivity and consequently decreasing the adverse effects of anticancer agents. Computer-aided drug design technology enables us to design and develop target-oriented and hence, selective therapeutic agents. We benefited that technology during our drug design process and selected our targets as ATP-dependent enzyme topoisomerase II (Topo II), epidermal growth factor receptor (EGFR) tyrosine kinase domain, carbonic anhydrase IX and tubulin-colchicine: stathmin-like domain complex, which has significant roles in the cancer development process by their biochemical and physiological activities. In the light of the results obtained from in silico studies, the title compounds displayed significant potential activity about possessing the qualification of being multi-target drugs by effecting and hitting a few of the main targets of cancer chemotherapy together and at the same time.

Key words: Thiosemicarbazide, synthesis, computer-aided drug design

Med-Science. 2020; 9(2): 305-13

 
 
 

Genetic polymorphism of CYP2C8*4 in a healthy Turkish population

Original Article

Genetic polymorphism of CYP2C8*4 in a healthy Turkish population

Zuhal Uckun Sahinogullari

   

Abstract
Cytochrome P4502C8 (CYP2C8) is a significant member of CYP enzyme family and metabolizes about 20% of commonly prescribed drugs and endogenous compounds. Single nucleotide polymorphisms in CYP2C8 gene may change CYP2C8 enzyme activity and therefore may affect the adverse reactions and efficacy of drugs metabolized by this. The purpose of the current investigation was to detect the genotype and allele frequencies of CYP2C8*4 in a healthy Turkish population and also to compare our findings with the other populations. CYP2C8*4 polymorphism was analyzed by polymerase chain reaction-restriction fragment length method using DNA samples isolated from 109 healthy Turkish volunteers. The genotype frequencies were 95.4% for the homozygous wild-type, 4.6% for heterozygous and 0.0 % for homozygous variant. According to this, the frequencies of wild type and variant alleles were determined as 0.977 and 0.023, respectively. The genotype frequencies did not deviate from the Hardy-Weinberg equilibrium. Significant population differences were observed when the findings were compared with those of other populations. This is the first investigation to examine the frequencies of CYP2C8*4 polymorphism in Turkish population. The determination of CYP2C8*4 polymorphism may provide useful data about the pharmacokinetics, efficacy and/or toxicity of its substrates and predisposition to some diseases and may help to improve personalized therapy in the future and also contributes to epidemiological studies.

Key words: CYP2C8, genetic polymorphism, drug metabolism, Turkish population

Med-Science. 2020; 9(2): 314-9

 
 
 

Linezolid drug interactions: A retrospective study

Original Article

Linezolid drug interactions: A retrospective study

Zeynep Ulku Gun, Omer Faruk Bahcecioglu, Selim Gok

   

Abstract
Linezolid is an antimicrobial drug which has good activity against clinically important gram-positive methicillin and vancomycin resistant microorganisms. However, linezolid is a lifesaving medicine for resistant infections, it can be responsible for severe drug interactions. Linezolid is a nonselective, weak, reversible inhibitor of monoamine oxidase A and B. That is why it can lead to increase activity of concomitant administrated monoamine oxidase inhibitors, serotonergic and adrenergic agents. This study is a one-month retrospective chart review of inpatients at a university hospital. All charts in a 1368 bed university hospital were reviewed via electronic records. Charts, which include linezolid have evaluated by clinical pharmacists and were assessed for prevalence and severity of potential drug-drug interactions using the UpToDate drug reference database. Fifty-four patients included in this study. Total number of interactions with linezolid was 86, which was 28.2 percent of all interactions. Eight of these interactions were in X category (avoid combination), 59 were in D category (consider therapy modification) and 19 were in C category (monitor therapy). There wasn’t any interaction classified as category B (no action needed). In our study, it was predicted that serotonergic toxicity and hypertension may develop in many patients due to concurrent administration of linezolid with serotonergic and/or adrenergic drugs. If the coadministration of these drugs is unavoidable, physicians should be alert to the symptoms and management of serotonergic toxicity and hypertension. The number of patients and its retrospective nature were limiting factors of our study. More comprehensive prospective studies are needed.

Key words: Linezolid, drug interaction, clinical pharmacist

Med-Science. 2020; 9(2): 320-2

 

Comparison of the antioxidant effect and phenolic profile of two Crataegus extracts

Original Article

Comparison of the antioxidant effect and phenolic profile of two Crataegus extracts

Hilal Bardakci, Kevser Ozdemir, Timur Hakan Barak, Elif Begum Yildirim, Feyza Sebnem Gorur

   

Abstract
This study was designed to evaluate the phenolic profiles and antioxidant potentials of two commercial Crataegus monogyna Jacq samples, which are commonly used for various medicinal purposes. One of the samples supplied from the pharmacy and the other sample supplied from the herbalist shop. To analyze phenolic contents of samples Total Phenolic Content, Total Flavonoid Content and Total Phenolic Acid Content Assays were carried out. Further hyperoside contents, which is one of the major component of the genus, were determined by HPTLC method. Antioxidant bioactivities were established by using CUPRAC (Cupric Reducing Antioxidant Capacity), FRAP (Ferric Reducing Antioxidant Power), DPPH radical scavenging activity and TOAC (Total Antioxidant Capacity) methods. The comparison between two samples showed that the pharmacy product has higher phenolic ingredients than herbalist shop, consequently, has higher antioxidant bioactivity.

Key words: Crataegus monogyna, pharmacy, hyperoside, antioxidant

Med-Science. 2020; 9(2): 323-6

 

Clinical analysis of intervertebral space infections

Original Article

Clinical analysis of intervertebral space infections

Ramazan Pasahan, Mehmet Arif Aladag

   

Abstract
Intervertebral space infections are a serious group of diseases caused by various microorganisms. These infections present various pathological processes with neurological deficit due to pain, deformity, instability and spinal cord compression, and lead to high morbidity and mortality. For this reason, our aim in this study was to contribute to the discussions in the literature by comparing etiologically different disc infections, by revealing different aspects of them, and by assessing them in terms of timing of surgical treatment retrospectively in the light of the literature. In this study, 59 patients with spinal infection were retrospectively evaluated between 2010 and 2015 at Inonu University Department of Neurosurgery. The patients were divided into groups based on age, gender, complaints, duration of complaints, preoperative and postoperative findings, and microorganism sites and compared in terms of sites, malformation, instability, and surgical procedures. Tissue samples taken from the histopathological and bacteriological (culture and cultural sensitivity) patients were examined. Lastly, the effects of each parameter on morbidity and mortality were investigated. It was concluded that early diagnosis and treatment decreases morbidity.

Key words: Spondylodiscitis, pyogenic, paraspinal abscess, instability

Med-Science. 2020; 9(2): 327-33

 
 
 

Prevalence and risk factors for allergic rhinitis and asthma in geriatric outpatients in three big cities of Turkey

Original Article

Prevalence and risk factors for allergic rhinitis and asthma in geriatric outpatients in three big cities of Turkey

Asli Kilavuz, Hacer Dogan Varan, Hakan Yavuzer, Nil Tekin, Eftal Erduran, Alper Doventas, Mustafa Cankurtaran, Selahattin Fehmi Akcicek, Ali Kokuludag

   

Abstract
This study aimed to investigate the lifetime prevalence and risk factors for allergic rhinitis and asthma in geriatric outpatients in three big cities of our country. Elderly patients visiting geriatric outpatient clinics at university hospitals were included in this study. Two questionnaires were completed by trained investigators in face-to-face interviews of 236 people aged 65–100 years. The median age was 73.71±7.09 year, and 63% participants were female. The prevalence of allergic rhinitis and asthma was found 15.3 % (n=36) and 10.2 % (n=24), respectively. The frequency of allergic rhinitis and asthma was high in females, in those with low education levels, in city, in persons having family history of atopy and in smokers, but it wasn’t statistically significant. Allergic diseases affect the elderly as well as young people. Female sex, low educational level, smoking, and living in a city are among the important risk factors for allergic rhinitis and asthma in the elderly.

Key words: Eelderly, allergic rhinitis, asthma

Med-Science. 2020; 9(2): 334-7

 

Platelet indices in graves disease, especially plateletcrit

Original Article

Platelet indices in graves disease, especially plateletcrit

Saliha Yildiz, Elif Eker

   

Abstract
Graves’ disease is an autoimmune thyrotoxicosis caused by thyroid receptor antibody and occurs in 1% of the population. Autoimmune events develop against cells in various tissues, including platelets. Platelet lymphocyte interaction can regulate these events. We investigated this relationship in our study. We compared leukocyte and platelet indices in 66 Graves patients and 38 control patients from hemogram parameters prospectively. Lymphocyte count, neutrophil count, platelet lymphocyte ratio, neutrophil lymphocyte ratio was insignificant between the two groups (p: 0.51, 0.13, 0.19, 0.097, respectively). Platelet count, PDW and PCT were significantly higher in Graves patients (p: 0.02, 0.03, 0.00, respectively), and MPV was significantly lower (p: 0.007). In the ROC curve analysis, the PCT threshold value was 0.24. Platelet indices in graves patients and especially PCT were more correlated with the disease than other hemogram parameters. This finding may help to clarify the pathogenesis of the disease.

Key words: Graves disease, platelet indices, plateletcrit

Med-Science. 2020; 9(2): 338-42