Malatya Turgut Ozal University, Faculty of Medicine, Department of Pulmonary Medicine, Malatya, Turkey
Obstructive sleep apnea (OSA) can cause local and systemic inflammation due to hypoxia, asphyxia, hypercapnia, respiratory acidosis. Searching for new inflammatory markers in OSA may facilitate the prediction of OSA-related conditions. Therefore, we aimed to investigate the relationship between OSA severity and serum gamma‑glutamyl transferase (GGT) levels. In the study, the GGT levels of the patients were compared according to the degree of OSA determined by polysomnography. The patients’ demographic, polysomnographic, and laboratory parameters were evaluated with SPSS 25 program. A total of 500 patients, 299 (59.8%) male and 201 (40.2%) female, were included in the study. The mean age of the patients was 47.9±13.1, and body mass index (BMI) was 32.2±6.6. There were 98 (19.6%) patients in the control group, 100 (20%) in the mild OSA group, 103 (20.6%) in the moderate OSA group, and 199 (39.8%) in the severe OSA group. When the BMI and desaturation index of the groups were compared, there was a statistical difference (respectively, p<0.001, p<0.001). When the serum GGT values of the groups were compared, the GGT values of the moderate and severe OSA groups were higher than the control group (respectively, p=0.011, p=0.001), and there was a statistically significant difference between the groups (p=0.001). There was a positive correlation between GGT levels and BMI (r=0.151, p=0.010). There was a positive correlation between GGT levels and age (r=0.615, p=0.029). As a result of our study, a relationship was found between high GGT levels and the severity of OSA. Serum GGT level may be a promising biomarker to identify OSA patients at high risk.
Keywords: Gamma glutamyl transferase, inflammation, body mass index
Conflict of interests: The authors declare that there is no conflict of interest in the study.
Financial Disclosure: The authors declare that they have received no financial support for the study.
Ethical approval: Ethics approval was obtained from the Inonu University Faculty of Medicine Ethics Committee (issue: 2021/1730).
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Altintop Geckil A, Ermis H, Gulbas G, et al. The relationship between serum gamma glutamyl transferase levels and obtructive sleep apnea severity. Med Science. 2022;11(3):1060-2.
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Corresponding Author: Aysegul Altıntop Geckil, Malatya Turgut Ozal University, Faculty of Medicine, Department of Pulmonary Medicine, Malatya, Turkey.