Inflammation plays a role in the pathogenesis of COPD by interfering with the protease/antiprotease and oxidant/antioxidant balance. There is no adequate data about the relationship between oxidative stress biomarkers and FEV1 values in stable COPD patients. Prospective cohort study, designed in tertiary care chest disease hospitals’ outpatient clinic. COPD patients were approved informed consent were included in the study. The total antioxidant status (TAS,), total oxidant status (TOS), total thiol (TT), native thiol (NT), IL1 IL6, and TNFα levels were measured. The mean age of 33 COPD patients who joined the study was 61±9,32 years, while their average body mass index (BMI) was 27±4,31 kg/m2. There was no statistically significant difference between the groups in terms of age, gender, weight, smoking status and comorbidities.
According to the results of the analysis, there was a statistically significant difference in TOS, TAS, oxidative stress index (OSI), TT, NT, DIS, IL-1β, IL-6, and TNFα between the control and COPD patient groups (p<0.001 for all variables). Compared to healthy controls, COPD patients had greater TOS, OSI, disulfide (DIS), IL-1β, IL-6, and TNFα levels. Healthy controls, had considerably higher TAS, TT, and NT values than the COPD group. No significant correlation was detected between the pulmonary function test results and oxidative stress markers. In conclusion, no significant correlation was detected between the pulmonary function test results and oxidative stress markers besides TOS was increased while TAS was decreased, in accordance with the pathophysiology of COPD, oxidative stress markers can also be utilized in COPD patients.
Keywords: COPD, stable, oxidative stress, TOS, TAS, OSI, TT, NT, DIS, IL-1β, IL-6, TNFα
Acknowledgement: The author thanks Eray Metin Guler for providing technical support for this study.
Conflict of Interests: The author contribute to the study and work with preparing the manuscript. And the author declare to have no conflict of interest directly or indirectly related to the manuscript contents.
Financial Disclosure: The authors declare that they have received no financial support for the study.
Ethical Approval: The approval of the ethics Committee Of Health Sciences University Turkey Hamidiye Scientific Research Ethics Committee dated 24/12/2021 and decision number 39/2.
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Bekir SA. Association between oxidative stress markers and lung function parameters in stable chronic obstructive pulmonary disease patients. Med Science. 2022;11(2): 770-4.
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Corresponding Author: Sumeyye Alparslan Bekir, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Pulmonary Diseases, Istanbul, Turkey.