Inonu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Malatya, Turkey
Cancer, a disease defined by rapid proliferation of cells, still remains one of the most feared diseases of the modern world. Many structurally different anti-carcinogenic drugs are used in several tumor types such as bladder, colon, ovary, breast, head and neck, testis, lung and prostate cancer. In this study, cytotoxic effects of the compounds with different linkers (ketone, oxime, alcohol, chlorine) between pyrazole and trifluoromethyl on MCF-7 (human breast adenocarcinoma), MDA-MB-231 (human breast adenocarcinoma), and HCT-116 (human colon cancer) cell lines were investigated. Compound a1 was observed to be the most potent compound with IC50 values of 5.84±0.76, 5.01±0.32, 5.57±0.02 µg.ml-1 against these cell lines, respectively. It was found that all compounds were very effective against all the tested cancer cell lines.
Keywords: Cytotoxic effect, 4-trifluoromethylphenyl, pyrazole
Conflict of interests: The authors declare that there is no conflict of interest in the study.
Financial Disclosure: The authors declare that they have received no financial support for the study.
Ethical approval: No consent of ethical is needed for this research
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Alagoz MA, Ozdemir Z, Hepokur C, Karakurt A. Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line Med Science. 2022;11(3):1212-6
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Corresponding Author:Mehmet Abdullah Alagoz, Inonu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Malatya, Turkey.