Vitamin B12 deficiency is a common health problem in the population. In this study, any hemogram parameter that can detect Vitamin B12 deficiency was investigated. A total of 121 patients, including 67 patients with vitamin B12 deficiency and 54 patients without vitamin B12 deficiency, were retrospectively investigated for vitamin B12 deficiency in Abant İzzet Baysal University, Faculty of Medicine, Department of Internal Medicine. The findings were analyzed statistically. All non-hemogram laboratory parameters were found to have a similar distribution. Among the hemogram parameters, the following parameters were significantly different between the groups; plateletcrit (PCT) value from normally distributed values (p=0.017), platelet distribution width (PDW) value from non-normally distributed values (p=0.030), and PDW/platelet (PLT) ratio (p=0.037) from values calculated from hemogram parameters. In addition, haemoglobin (HGB) and mean corpuscular volume (MCV) values were found to be significantly correlated (p=0.0001). There was a significant difference in the presence of anaemia between the groups according to gender (p=0.0001). When evaluated separately, this significant difference persisted only in women (p=0.0001). ROC analysis results of PDW, PCT and PDW/PLT ratio values, which were significant in the comparisons, revealed that PDW predicted Vitamin B12 deficiency with the highest specificity (63.7%) and sensitivity (64.2%). Our results showed that not only HGB and MCV but also PCT, PDW and PDW/PLT parameters can be useful in detecting the Vitamin B12 deficiency-related processes.
Keywords: Anaemia, hemogram parameters, vitamin B12
Conflict of Interests: The authors declare that they have no competing interests.
Financial Disclosure: All authors declare no financial support.
Ethical Approval: Our study was approved the provisions of the World Medical Association’s Declaration of Helsinki, which was developed as a statement of ethical principles to provide guidance to physicians and other participants in medical research involving human subjects. Our study was approved by the local Ethics Committee (no:293).
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Yazar O, Gurler M. Retrospective investigation of the effect of Vitamin B12 deficiency
on hemogram parameters. Med Science. 2022;11(2):602-12.
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Corresponding Author: Mujgan Gurler, Bolu Abant Izzet Baysal University, Faculty of Medicine, Department of Internal Medicine, Bolu, Turkey