Adıyaman Training and Research Hospital, Department of Cardiology, Adıyaman, Türkiye
It is argued that the average life expectancy for obsessive-compulsive disorder (OCD) decreases. However, data on the reasons for this are limited. This study compared sociodemographic characteristics, electrocardiogram (ECG) parameters, and laboratory values of 56 patients diagnosed with OCD with 60 healthy controls. We aimed to interpret the risk of cardiovascular disease in OCD through ECG parameters. OCD patients and the control group did not differ statistically in age or gender (p=0.689 and p=0.756, accordingly). Patient’s with OCD have significantly longer corrected QT interval (QTc) (p=0.001). In comparison to the control group, OCD patients had statistically greater frontal QRS-T angle (fQRS-T) (p=0.044). The levels of platelet-to-lymphocyte ratio (PLR), pan immune inflammation value (PIV), and systemic immune inflammation index (SII) were elevated significantly in OCD patients (p=0.001, p=0.002, and p=0.009, respectively). The monocytes to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) and atherogenic index of plasma (AIP) values of OCD patients were significantly greater than those of the control group (p<0.001 and p=0.006). Based on the Receiver Operating Characteristic (ROC) analysis, MHR had the highest area under curve (AUC) value (AUC=0.699, p<0.001, cut-off=0.0097). It was determined that a 0.0097 increase in MHR value could be used in diagnosing OCD with 66% sensitivity and 71% specificity. According to the results of our study, cardiovascular mortality can be predicted by measuring fQRS-T in the electrocardiogram or AIP and MHR values in laboratory findings in OCD patients, and treatments and recommendations can be made in this regard. Calculating MHR and fQRS-T can also be used in routine practice because it is inexpensive and easy to apply. It seems possible that clinicians can reduce mortality and morbidity in this patient group by examining these parameters more in routine practice.
Keywords: Obsessive-compulsive disorder, frontal QRS-T angle, monosit HDL ratio, atherogenic index of plasma
Conflict of interests
The authors declare that there is no conflict of interest in the study.
The authors declare that they have received no financial support for the study.
Research methodology approval was provided by the Academic Ethical Review Committee of the University of Adıyaman (Approval date: 2021-12-14; IRB Number: 2021 / 10-22).
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Abus S, Kapici Y, Ayhan S et al. Comparative study of frontal QRS-T angle and inflammatory parameters in obsessive compulsive disorder patients and healthy control group. Med Science. 2022;11(4):1473-7
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Corresponding Author: Yasar Kapici, Kahta State Hospital, Department of Psychiatry, Adıyaman, Türkiye