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A case of TSHoma mimicing Graves ‘disease and makes GH cosecrete

Case Report

A case of TSHoma mimicing Graves 'disease and makes GH cosecrete

Receiving Date: 30 June 2022

Accept Date: 15 October 2022

Available Online: 27 November 2022

doi: 10.5455/medscience.2022.06.151
Med-Science. 2022;11(4):1734-7

Conflict of interests
The authors declare that there is no conflict of interest in the study.

Financial Disclosure
The authors declare that they have received no financial support for the study.

Ethical approval
Ethical approval was not received because it is a case repor.

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CITATION
Aydin ES. Evren B. Sahin I. A case of TSHoma mimicing Graves ‘disease and makes GH cosecrete. Medicine Sci. 2022;11(4):1734-7

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Corresponding Author: Emi̇ne Sener Aydin, Inönü Universi̇ty, Medicine Faculty, Depertment of Endochronology And Metaboli̇s, Malatya, Türkiye
E-mail: dreminesener@windowslive.com

Is urotensin 2 levels related to disease progression in acromegaly

Original Article

Is urotensin 2 levels related to disease progression in acromegaly

Faruk Kilinc, Nevzat Gozel, Bahri Evren, Zafer Pekkolay, Erkan Cakmak, Fethi Ahmet Ozdemir

Abstract

The study aimed to compare serum Urotensin-2 stages in the patients having active acromegaly with healthy individuals and to reveal and discuss the possible effects of UII on vascular changes in acromegaly patients. In this prospective, serum urotensin stages of 30 active acromegalic patients who are followed up in the experienced adult endocrinology center were compared with the serum urotensin stages of 30 healthy volunteers. Patients’ IGF-1 along with GH were carefully measured by ECLIA method, and serum urotensin stages, by ELISA method. There was no variation between two groups comparing there age (p = 0.43). Patient group, mean GH was 6.60 ng / mL with mean IGF-1 stage of 355.2 ng / mL. The mean urotensin stage was 3.62±2.27 pmol / L in the acromegaly group, 4.82±2.87 pmol / L in the healthy control group. There was no significant positive correlation of urotensin with IGF-1 stages (r = 0.11, p>0.05). Similarly, the results did not display significant positive correlation urotensin stage with GH (r = 0.13, p>0.05). Serum urotensin-2 stage was lower in acromegaly patients compared to the healthy group (control) and this variation was not statistically significant.

Keywords: Urotensin-2, acromegaly, vasoconstriction, vasodilation

Med-Science. 2021; 10(4): 1534-7

An unusual cause of hypoglycemia; the case of a male patient with Munchausen’s Syndrome

Case Report

An unusual cause of hypoglycemia; the case of a male patient with Munchausen’s Syndrome

Selin Genc, Bahri Evren, Ayshe Slocum, Abdulkadir Bozbay, Emine Sener Aydin, Ibrahim Sahin 

Abstract

Munchausen’s Syndrome is a psychiatric illness in which patients create potentially life-threatening symptoms for the purpose of admission to a hospital or other primary gains. A 23-year-old male patient was admitted to the Inonu University, Turgut Ozal Medical Center Endocrinology Inpatient Unit with hypoglycemic attacks. The patient had hypoglycemia that required intensive dextrose infusion. Studies conducted after his hospitalization revealed that the patient intentionally injected himself with high doses of insulin in order to be hospitalized. A diagnosis of factitious hypoglycemia and Munchausen Syndrome (MS) was made. The patient was followed up with recommendations from the psychiatry department. Factitious hypoglycemia, resulting from deliberate usage of blood glucose-lowering medications in the absence of hyperglycemia, is characterized by frequent episodes of hypoglycemia and recurrent hospitalizations and causes a variety of severe symptoms. Typical signs include low blood glucose levels, suppressed c-peptide and pro-insulin levels, and inappropriately high insulin levels. The purpose behind the current case report is to emphasize the significance of considering MS in the differential diagnosis of patients presenting with hypoglycemia and, although it is more prevalent among females, to demonstrate that this psychiatric illness can also present itself among male patients.

Keywords: Hypoglycemia, insulin, Munchausen Syndrome

Med-Science. 2021; 10(4): 1546-9