Protective effect of Nigella sativa oil against thioacetamide-induced liver injury in rats
Kevser Tanbek, Elif Ozerol, Sedat Bilgic, Mustafa Iraz, Nurhan Sahin, Cemil Colak
DOI: 10.5455/medscience.2016.05.8531 · Page: 96-103 · 62 Views · 2 Downloads · 0 Citations
Abstract
Abstract
antioxidant which is known to have liver protective effects, against thioacetamide (TAA)-induced liver injury. Accordingly, we aimed to investigate the toxicity of a hepatotoxic agent, thioacetamide, compared the NSO and NAC liver preventive effects in experimental animal model. Wistar-albino rats were randomly allocated to five groups, each consisting of eight rats, and were subjected to different treatment regimens for 6 days. Alanine aminotransferase (ALT), malondialdehyde (MDA), and protein carbonyl (PC) levels decreased significantly by NSO treatment (P
Keywords : Liver; N-acetylcysteine (NAC); Nigella sativa oil (NSO); Thioacetamide (TAA); ROS