Kinetic evaluation of L-Dopa loaded WGA-grafted nanoparticles
Sema Arisoy, Tansel Comoglu
DOI: 10.5455/medscience.2019.08.9209 · Page: 385-8 · 84 Views · 5 Downloads · 0 Citations
Abstract
Abstract
Drug release is a critical parameter in the discipline of drug delivery for years. The determination of in vitro release kinetics of active substances from drug systems plays a critical role in predicting and managing of both efficacy and safety. Kinetics is more than a scientific goal; it is a fundamental quality parameter of all type of drugs. Kinetic models are developed to determine drug release from delivery systems which the released drug amount (Q) is plotted versus time; t or as a function of time Q=f (t). Kinetic models facilitate the understanding of release pattern in enabling to design an effective formulation. In this study wheat germ agglutinin (WGA) conjugated, L-Dopa loaded, poly lactic-co-glycolic acid (PLGA) nanoparticles were analyzed for determining the release pattern of L-Dopa. Higuchi, zero order, first order, Hixon Crowell and Korsmeyer-Peppas models were investigated. Hixson Crowell model was found to be the best fitted kinetic model in L-Dopa loaded nanoparticles (r2 =0.9828).
Key words: Kinetic evaluation, first order, zero order, hixon-crowell, korsmeyer-pepas, higuchi
Keywords : Kinetic evaluation; first order; zero order; hixon-crowell; korsmeyer-pepas; higuchi