Oxidative Stress Status, Metabolic Profile and Cardiovascular Risk Factors in Patients with Polycystic Ovary Syndrome
Aysun Bay Karabulut, Cakmak M., Kiran Rt, Sahin I
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Abstract
We aimed to investigate the relationships between Polycystic Ovary Syndrome (PCOS) and
oxidative stress status, metabolic profile and cardiovascular risk factors in patients with
polycystic ovary syndrome
Methods: We measured Body Mass Index (BMI), glucose, cholesterol, triglyceride, HDL,
LDL, high sensitive CRP (hsCRP), insulin, AST and ALT, Malondialdehyde (MDA),
erythrocyte reduced glutathione (GSH), Nitric Oxide (NO) levels in PCOS patients and in
normal individuals.
We used spectrophotometrical method to determine glucose, cholesterol, triglyceride, HDL,
LDL, AST and ALT levels. Nepholometrical method was used to measure hsCRP.
Immunoassay method was used for insulin. Oxidant status was evaluated by using erythrocyte
MDA and NO levels, while antioxidant status was evaluated by GSH levels.
Results: Study population were consist of 32 women with PCOS (Study group) and 32 healthy
volunteers (Control group). In study group, we found statistically higher levels of MDA, NO
(p<0.001) and lower levels of GSH (p<0.001) compared to those of controls. hsCRP, insulin
(p<0.001) and triglyceride (p<0.05) levels were statistically higher in study group. We also
observed a statistically higher BMI in women with PCOS (p<0.05).
Conclusion: Our results revealed that PCOS is associated with imbalanced
oxidative/antioxidative status, impaired metabolic profile and increased cardiovascular risk
factors.
Keywords : PCOS; oxidants; antioxidants; MDA; NO; GSH