Clinical Significance of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume for Predicting the Severity of Hepatic Fibrosis in Patients with Chronic Hepatitis B
Alpaslan Tanoglu, Ergenekon Karagoz, Asım Ulcay, Vedat Turhan, Muammer Kara, Yusuf Yazgan
DOI: 10.5455/medscience.2015.04.8342 · Page: 147-59 · 61 Views · 0 Downloads · 0 Citations
Abstract
Abstract
In this study, we aimed to determine the clinical significance of the neutrophil to lymphocyte
(NLR) ratio, mean platelet volume (MPV) and other biochemical parameters for predicting
the degree of liver fibrosis in patients with chronic hepatitis B (CHB) infection. A total of 95
biopsy-proven naïve CHB cases patients were included in the study. The complete blood
count variables including white blood cell, hemoglobin, hematocrit, platelet count, neutrophil,
lymphocyte, MPV, and other routine biochemical parameters were tested. Liver biopsy
samples were examined using the Ishak scoring system. Individuals with a fibrosis score of 0,
1 and 2 were included in Group 1 and 3,4,5 and 6 were included in Group 2. Data analyses
were carried out using SPSS 15 software. Statistical significance was set at a p-value of less
than 0.05.Of the 95 cases, 76 (80%) were men and 19 (20%) were women. The mean age of
the patients was 39.91±18.6 years, and 30 cases (31.5%) had HBeAg positivity. Fibrosis
scores of 36 cases (37.8%) were greater than or equal to 3, whereas 59 cases (62.2%) had
fibrosis scores less than 3. There was a significant difference between these two groups for
NLR (Group 1; 2.38± 0.96, Group 2; 1.64 ± 0.60, p<0.001) and MPV (Group 1; 8.13± 1.20,
Group 2; 8.77 ± 1.47, p<0.05). We have compared the receiver operating characteristic
curves for the diagnostic performance of aspartate aminotransferase, alanine
aminotransferase, platelet count, NLR, MPV, and albumin identifying fibrosis in CHB and
area under the curve values for these variables were 0.70, 0.49, 0.27, 0.20, 0.67, and 0.13,
respectively.NLR values were significantly lower and MPV values were significantly higher in
hepatitis B virus-infected patients with advanced liver fibrosis and can be defined as
independent noninvasive predicting factors for hepatic fibrosis. Further studies are required
to determine the associations between NLR, MPV and the severity of fibrosis in chronic
hepatitis B patients.
Keywords: Chronic hepatitis B, mean platelet volume, neutrophil to lymphocyte ratio, liver fibrosis
Keywords : Chronic hepatitis B; mean platelet volume; neutrophil to lymphocyte ratio; liver fibrosis