Evaluation of interleukin-33 and osteopontin levels in well and poorly regulated diabetes mellitus type 2

IL-33 is one of the novel IL-1 family members which are secreted in many tissues. Osteopontin (OPN) is a highly phosphorylated and glycosylated sialoprotein synthesized primarily in bone tissue, which the major role is to participate in biomineralization. Both IL-33 and OPN are mentioned associated with inflammatory disorders. Diabetes Mellitus Type 2 (T2DM) is a metabolic disorder in glucose homeostasis, which its pathophysiology involves a low-grade chronic inflammation. The aim of this study is to evaluate the IL-33 and OPN levels in well and poorly regulated T2DM patients. Three group were determined as; T2DM with HbA1c level below 8% as Group HbA1c <8, T2DM with HbA1c level of 8% and above as Group HbA1c ≥8, and control group consisting of healthy individuals respectively. Each group included 50 participant (n=50). Age, fasting plasma glucose, HbA1c and lipid parameters (total cholesterol, triglyceride, LDL, HDL), IL-33 and OPN values were examined. There was a significant statistical difference between the fasting plasma glucose, HbA1c, triglyceride, and HDL levels of the groups (p<0.001). OPN levels of the groups were not found statistically different but IL-33 levels were found to be significantly higher in the HbA1c <8 group compared to the control group (p=0.0108). IL-33 and OPN levels do not differ in terms of well or poorly regulation in T2DM patients and HbA1c level alone, is insufficient to be a predictor of OPN and IL-33 activity.